Guanosine 5'-triphosphate trisodium salt hydrate - 95%, high purity , CAS No.36051-31-7

In stock

Item Number

G106782

Grouped product items
SKU	Size	Availability	Price
G106782-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$9.90
G106782-25mg	25mg	6	$20.90
G106782-100mg	100mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$68.90
G106782-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$155.90
G106782-1g	1g	6	$414.90
G106782-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,867.90

Activator of signal transducing G proteins.

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Basic Description

Synonyms	Guanosine 5'-triphosphate sodium salt hydrate, >=95% (HPLC) \| trisodium;[[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-oxidophosphoryl] phosphate \| Guanosine 5'-triphosphate sodium salt hydrate, >=9
Specifications & Purity	≥95%
Biochemical and Physiological Mechanisms	Nucleoside triphosphate. Functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. Activates signal transducing G proteins。
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description	Guanosine 5′-triphosphate (GTP), a purine trinucleotide, is a substrate for RNA polymerases and a wide range of GTPase including G-protein coupled receptor (GPCR) GTPases and cell signaling and cycling associated guanine nucleotide exhange factors (GEF).

Names and Identifiers

Pubchem Sid	504773326
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504773326
IUPAC Name	trisodium;[[[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-oxidophosphoryl] phosphate
INCHI	InChI=1S/C10H16N5O14P3.3Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;/q;3*+1/p-3/t3-,5-,6-,9-;;;/m1.../s1
InChi Key	KZRMTEVIDYXWQW-CYCLDIHTSA-K
Canonical SMILES	C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)OP(=O)([O-])OP(=O)([O-])[O-])O)O)N=C(NC2=O)N.[Na+].[Na+].[Na+]
Isomeric SMILES	C1=NC2=C(N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)([O-])OP(=O)([O-])[O-])O)O)N=C(NC2=O)N.[Na+].[Na+].[Na+]
WGK Germany	3
PubChem CID	135445727
Molecular Weight	589.13
Beilstein	3585677

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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9 results found

Lot Number	Certificate Type	Date	Item
L2010089	Certificate of Analysis	Sep 10, 2024	G106782
H2205095	Certificate of Analysis	Jun 13, 2022	G106782
H2205093	Certificate of Analysis	Jun 13, 2022	G106782
H2205096	Certificate of Analysis	Jun 13, 2022	G106782
H2205094	Certificate of Analysis	Jun 13, 2022	G106782
G1811046	Certificate of Analysis	May 07, 2022	G106782
F1829084	Certificate of Analysis	Apr 27, 2022	G106782
F23061523	Certificate of Analysis	Dec 11, 2021	G106782
L2107597	Certificate of Analysis	Dec 11, 2021	G106782

Chemical and Physical Properties

Solubility	solubility H2O: 50 mg/mL
Molecular Weight	589.130 g/mol
XLogP3
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	16
Rotatable Bond Count	7
Exact Mass	588.936 Da
Monoisotopic Mass	588.936 Da
Topological Polar Surface Area	303.000 Å²
Heavy Atom Count	35
Formal Charge	0
Complexity	907.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	4

References

1. Dyer MS et al.. (2021) Mislocalisation of TDP-43 to the cytoplasm causes cortical hyperexcitability and reduced excitatory neurotransmission in the motor cortex.. J Neurochem, 157 (4): (1300-1315). [PMID:33064315]
2. Kinosita Y et al.. (2020) Motile ghosts of the halophilic archaeon, Haloferax volcanii.. Proc Natl Acad Sci U S A, 117 (43): (26766-26772). [PMID:33051299]

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Basic Description