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3-{[(2,6-dichlorophenyl)methyl]amino}-6,7-dimethoxy-1H,4H-indeno[1,2-c]pyrazol-4-one , CAS No.D609015, Inhibitor of eukaryotic translation initiation factor 2 alpha kinase 1

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3-{[(2,6-dichlorophenyl)methyl]amino}-6,7-dimethoxy-1H,4H-indeno[1,2-c]pyrazol-4-one , CAS No.D609015, Inhibitor of eukaryotic translation initiation factor 2 alpha kinase 1

Moligand™

PubChem CID: 45375987

In stock

Item Number

D609015

Grouped product items
SKU	Size	Availability	Price	Qty
D609015-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,400.90
D609015-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,000.90

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eukaryotic translation initiation factor 2 alpha kinase 1 Inhibitor (1)

Basic Description

Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of eukaryotic translation initiation factor 2 alpha kinase 1

Associated Targets(Human)

EIF2AK1 Tchem Eukaryotic translation initiation factor 2-alpha kinase 1 (2 Activities)

Discover Target: EIF2AK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	3-{[(2,6-dichlorophenyl)methyl]amino}-6,7-dimethoxy-1H,4H-indeno[1,2-c]pyrazol-4-one
INCHI	InChI=1S/C19H15Cl2N3O3/c1-26-14-6-9-10(7-15(14)27-2)18(25)16-17(9)23-24-19(16)22-8-11-12(20)4-3-5-13(11)21/h3-7H,8H2,1-2H3,(H2,22,23,24)
InChi Key	UUDNGLPFGYJJQX-UHFFFAOYSA-N
Canonical SMILES	COc1cc2c3[nH]nc(c3C(=O)c2cc1OC)NCc1c(Cl)cccc1Cl
Isomeric SMILES	COC1=C(C=C2C(=C1)C3=C(C2=O)C(=NN3)NCC4=C(C=CC=C4Cl)Cl)OC
PubChem CID	45375987

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Specifications

Specification Sheet

References

1. Rosen MD, Woods CR, Goldberg SD, Hack MD, Bounds AD, Yang Y, Wagaman PC, Phuong VK, Ameriks AP, Barrett TD et al.. (2009) Discovery of the first known small-molecule inhibitors of heme-regulated eukaryotic initiation factor 2alpha (HRI) kinase.. Bioorg Med Chem Lett, 19 (23): (6548-51). [PMID:19854648] [10.1021/op500134e]

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