Grouped product items

SKU

Size

Availability

Price

Qty

H157171-1g

$14.90

H157171-5g

$49.90

H157171-25g

25g

$176.90

H157171-100g

100g

$499.90

Basic Description

Synonyms	AC-24628 \| DS-11081 \| p-Hydroxy-L-phenylglycine \| (S)-2-AMINO-2-(4-HYDROXYPHENYL)ACETIC ACID \| (S)-Amino-(4-hydroxyphenyl)acetic acid \| 4-Hydroxy-L-phenylglycine \| CAS-32462-30-9 \| H-Phg(4-OH)-OH \| Oxfenicina \| BDBM50403035 \| H1389 \| SCHEMBL122315 \| UNII-
Specifications & Purity	≥99%
Shipped In	Normal

Associated Targets(Human)

CPT2 Tchem Carnitine palmitoyltransferase 2 (510 Activities)

Discover Target: CPT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC1A4 Tbio Neutral amino acid transporter A (18 Activities)

Discover Target: SLC1A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

KB (17409 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CPT1A Tchem Carnitine O-palmitoyltransferase 1, liver isoform (507 Activities)

Discover Target: CPT1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CPT1B Tchem Carnitine O-palmitoyltransferase 1, muscle isoform (497 Activities)

Discover Target: CPT1B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

SLC1A5 Tchem Neutral amino acid transporter B(0) (65 Activities)

Discover Target: SLC1A5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Galc Galactocerebrosidase (11 Activities)

Discover Target: Galc

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Rattus norvegicus (775804 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Grin1 Glutamate NMDA receptor (6467 Activities)

Discover Target: Grin1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc1a5 Amino acid transporter (271 Activities)

Discover Target: Slc1a5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Slc7a10 Asc-type amino acid transporter 1 (14 Activities)

Discover Target: Slc7a10

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	488183269
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/488183269
IUPAC Name	(2S)-2-amino-2-(4-hydroxyphenyl)acetic acid
INCHI	InChI=1S/C8H9NO3/c9-7(8(11)12)5-1-3-6(10)4-2-5/h1-4,7,10H,9H2,(H,11,12)/t7-/m0/s1
InChi Key	LJCWONGJFPCTTL-ZETCQYMHSA-N
Canonical SMILES	C1=CC(=CC=C1C(C(=O)O)N)O
Isomeric SMILES	C1=CC(=CC=C1[C@@H](C(=O)O)N)O
WGK Germany	3
PubChem CID	36143
Molecular Weight	167.16
Beilstein	3589850
Reaxy-Rn	3589845

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
E2415394	Certificate of Analysis	Mar 13, 2024	H157171
C2307509	Certificate of Analysis	Jan 31, 2023	H157171
C2307498	Certificate of Analysis	Jan 31, 2023	H157171
C2307486	Certificate of Analysis	Jan 31, 2023	H157171
C2307462	Certificate of Analysis	Jan 31, 2023	H157171
C2307484	Certificate of Analysis	Jan 31, 2023	H157171
C2307461	Certificate of Analysis	Jan 31, 2023	H157171
A1922047	Certificate of Analysis	Dec 07, 2022	H157171
I2207779	Certificate of Analysis	Jul 16, 2022	H157171
I2207780	Certificate of Analysis	Jul 16, 2022	H157171

Chemical and Physical Properties

Specific Rotation[α]	155° (C=1,1mol/L HCl)
Melt Point(°C)	214°C(dec.)(lit.)
Molecular Weight	167.160 g/mol
XLogP3	-2.100
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	2
Exact Mass	167.058 Da
Monoisotopic Mass	167.058 Da
Topological Polar Surface Area	83.600 Å²
Heavy Atom Count	12
Formal Charge	0
Complexity	164.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Safety and Hazards(GHS)

Pictogram(s)	GHS07
Signal	Warning
Hazard Statements	H315:Causes skin irritation H319:Causes serious eye irritation H335:May cause respiratory irritation H302:Harmful if swallowed
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do - continue rinsing. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P403+P233:Store in a well-ventilated place. Keep container tightly closed. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P301+P317:IF SWALLOWED: Get medical help. P337+P317:If eye irritation persists: Get medical help. P332+P317:If skin irritation occurs: Get medical help. P319:Get medical help if you feel unwell.
WGK Germany	3
Reaxy-Rn	3589845

Specifications

Specification Sheet

References

1. Gertrud Angsten,Sven Valind,Reijo Takalo,Henrik Neu,Staffan Meurling,Bengt Långström. (2005-06-29) Inhibition of carnitine-acyl transferase I by oxfenicine studied in vivo with [11C]-labeled fatty acids.. Nuclear medicine and biology, 32 ((5)): (495-503). [PMID:15982580]
2. Tom L Broderick,Bryan Glick. (2005-08-24) Effect of gender and fatty acids on ischemic recovery of contractile and pump function in the rat heart.. Gender medicine, 1 ((2)): (86-99). [PMID:16115587]
3. Steven A Unger,Jennifer A Kennedy,Kate McFadden-Lewis,Kirsty Minerds,Geraldine A Murphy,John D Horowitz. (2005-11-25) Dissociation between metabolic and efficiency effects of perhexiline in normoxic rat myocardium.. Journal of cardiovascular pharmacology, 46 ((6)): (849-855). [PMID:16306812]
4. Naotoshi Hirota,Shuichi Otabe,Hitomi Nakayama,Xiaohong Yuan,Kentaro Yamada. (2006-05-19) Sequential activation of caspases and synergistic beta-cell cytotoxicity by palmitate and anti-Fas antibodies.. Life sciences, 79 ((13)): (1312-1316). [PMID:16707142]
5. M G Marina Prendes,J V García,G Testoni,M A Fernández,J C Perazzo,E A Savino,A Varela. (2006-06-07) Influence of fasting on the effects of dimethylamiloride and oxfenicine on ischaemic-reperfused rat hearts.. Archives of physiology and biochemistry, 112 ((1)): (31-36). [PMID:16754201]
6. Khalid Abozguia,Kieran Clarke,Leong Lee,Michael Frenneaux. (2006-08-26) Modification of myocardial substrate use as a therapy for heart failure.. Nature clinical practice. Cardiovascular medicine, 3 ((9)): (490-498). [PMID:16932766]
7. Xihou Yin,T Mark Zabriskie. (2006-09-29) The enduracidin biosynthetic gene cluster from Streptomyces fungicidicus.. Microbiology (Reading, England), 152 ((Pt 10)): (2969-2983). [PMID:17005978]
8. Isidore C Okere,Margaret P Chandler,Tracy A McElfresh,Julie H Rennison,Theodore A Kung,Brian D Hoit,Paul Ernsberger,Martin E Young,William C Stanley. (2007-01-05) Carnitine palmitoyl transferase-I inhibition is not associated with cardiac hypertrophy in rats fed a high-fat diet.. Clinical and experimental pharmacology & physiology, 34 ((1-2)): (113-119). [PMID:17201745]
9. Lufang Zhou,Hazel Huang,Celvie L Yuan,Wendy Keung,Gary D Lopaschuk,William C Stanley. (2007-12-18) Metabolic response to an acute jump in cardiac workload: effects on malonyl-CoA, mechanical efficiency, and fatty acid oxidation.. American journal of physiology. Heart and circulatory physiology, 294 ((2)): (H954-H960). [PMID:18083904]
10. Manoj Gandhi,Barry A Finegan,Alexander S Clanachan. (2008-04-15) Role of glucose metabolism in the recovery of postischemic LV mechanical function: effects of insulin and other metabolic modulators.. American journal of physiology. Heart and circulatory physiology, 294 ((6)): (H2576-H2586). [PMID:18408129]
11. Jeanne M Davidsen,Craig A Townsend. (2008-11-26) Identification and characterization of NocR as a positive transcriptional regulator of the beta-lactam nocardicin A in Nocardia uniformis.. Journal of bacteriology, 191 ((3)): (1066-1077). [PMID:19028891]
12. Mònica Prieto,Silvia Mayor,Paul Lloyd-Williams,Ernest Giralt. (2009-10-30) Use of the SPhos ligand to suppress racemization in arylpinacolboronate ester Suzuki couplings involving alpha-amino acids. Synthesis of biaryl derivatives of 4-hydroxyphenylglycine, tyrosine, and tryptophan.. The Journal of organic chemistry, 74 ((23)): (9202-9205). [PMID:19863122]
13. David Hauton,Germaine M Caldwell. (2012-01-10) Cardiac lipoprotein lipase activity in the hypertrophied heart may be regulated by fatty acid flux.. Biochimica et biophysica acta, 1821 ((4)): (627-636). [PMID:22226882]
14. Stephan Kastner,Sebastian Müller,Lavanya Natesan,Gabriele M König,Reinhard Guthke,Markus Nett. (2012-02-07) 4-Hydroxyphenylglycine biosynthesis in Herpetosiphon aurantiacus: a case of gene duplication and catalytic divergence.. Archives of microbiology, 194 ((6)): (557-566). [PMID:22307823]
15. Gerald Maarman,Erna Marais,Amanda Lochner,Eugene F du Toit. (2012-03-13) Effect of chronic CPT-1 inhibition on myocardial ischemia-reperfusion injury (I/R) in a model of diet-induced obesity.. Cardiovascular drugs and therapy, 26 ((3)): (205-216). [PMID:22407171]
16. Wendy Keung,John R Ussher,Jagdip S Jaswal,Monique Raubenheimer,Victoria H M Lam,Cory S Wagg,Gary D Lopaschuk. (2012-11-10) Inhibition of carnitine palmitoyltransferase-1 activity alleviates insulin resistance in diet-induced obese mice.. Diabetes, 62 ((3)): (711-720). [PMID:23139350]
17. Heinz Rupp,Thomas P Rupp,Bernhard Maisch. (2005-05-26) Fatty acid oxidation inhibition with PPARalpha activation (FOXIB/PPARalpha) for normalizing gene expression in heart failure?. Cardiovascular research, 66 ((3)): (423-426). [PMID:15914105]
18. Monica Prieto,Silvia Mayor,Katy Rodríguez,Paul Lloyd-Williams,Ernest Giralt. (2007-01-27) Racemization in suzuki couplings: a quantitative study using 4-hydroxyphenylglycine and tyrosine derivatives as probe molecules.. The Journal of organic chemistry, 72 ((3)): (1047-1050). [PMID:17253834]
19. Chung-Jen Chiang,Jong-Tzer Chern,Jen-You Wang,Yun-Peng Chao. (2008-07-19) Facile immobilization of evolved agrobacterium radiobacter carbamoylase with high thermal and oxidative stability.. Journal of agricultural and food chemistry, 56 ((15)): (6348-6354). [PMID:18636689]
20. Tony Ly,Ryan R Julian. (2009-03-17) Tracking radical migration in large hydrogen deficient peptides with covalent labels: facile movement does not equal indiscriminate fragmentation.. Journal of the American Society for Mass Spectrometry, 20 ((6)): (1148-1158). [PMID:19286394]
21. H Yu,S Yang,W Jiang,Y Yang. (2010-02-09) Efficient biocatalytic production of D-4-hydroxyphenylglycine by whole cells of recombinant Ralstonia pickettii.. Folia microbiologica, 54 ((6)): (509-515). [PMID:20140718]
22. M G Marina Prendes,R Hermann,M E Torresin,P Souto,S Tallis,E A Savino,A Varela,M M Jaitovich. (2011-05-07) Involvement of energetic metabolism in the effects of ischemic postconditioning on the ischemic-reperfused heart of fed and fasted rats.. The journal of physiological sciences : JPS, 61 ((4)): (303-312). [PMID:21547611]
23. Rong Shi,Christine Munger,Lindsay Kalan,Traian Sulea,Gerard D Wright,Miroslaw Cygler. (2012-07-04) Sulfonation of glycopeptide antibiotics by sulfotransferase StaL depends on conformational flexibility of aglycone scaffold.. Proceedings of the National Academy of Sciences of the United States of America, 109 ((29)): (11824-11829). [PMID:22753479]

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4-Hydroxy-L-(+)-2-phenylglycine - 99%, high purity , CAS No.32462-30-9