Adenosine 5′-triphosphate disodium salt hydrate - BioReagent, ≥99%(HPLC), from microbial, high purity , CAS No.34369-07-8

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Item Number

A755865

Grouped product items
SKU	Size	Availability	Price
A755865-1g	1g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$112.90
A755865-5g	5g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$315.90
A755865-10g	10g	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$581.90

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Basic Description

Specifications & Purity	BioReagent, ≥99%(HPLC), from microbial
Biochemical and Physiological Mechanisms	P2 purinergic agonist; increases activity of Ca2+-activated K+ channels; substrate for ATP-dependent enzyme systems
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	BioReagent
Product Description	Adenosine 5γ-triphosphate (ATP) is a central component of energy storage and metabolism in vivo. ATP is use in many cellular processes, respiration, biosynthetic reactions, motility, and cell division. ATP is a substrate of many kinases involved in cell signaling and of adenylate cyclase(s) that produce the second messenger cAMP. ATP provides the metabolic energy to drive metabolic pumps. ATP serves as a coenzyme in a wide array of enzymatic reactions.

Names and Identifiers

IUPAC Name	disodium;[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-oxidophosphoryl] hydrogen phosphate;hydrate
INCHI	InChI=1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1
InChi Key	NTBQNWBHIXNPRU-MSQVLRTGSA-L
Canonical SMILES	C1=NC(=C2C(=N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)OP(=O)([O-])OP(=O)(O)[O-])O)O)N.O.[Na+].[Na+]
Isomeric SMILES	C1=NC(=C2C(=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)([O-])OP(=O)(O)[O-])O)O)N.O.[Na+].[Na+]
WGK Germany	3
Alternate CAS	987-65-5
PubChem CID	16218877
Molecular Weight	551.14(anhydrous basis)

Chemical and Physical Properties

Solubility	H 2 O: 50 mg/mL, clear, colorless
Specific Rotation[α]	-19° (C=3,H2O)
Molecular Weight	569.160 g/mol
XLogP3
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	18
Rotatable Bond Count	8
Exact Mass	568.97 Da
Monoisotopic Mass	568.97 Da
Topological Polar Surface Area	286.000 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	789.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	4
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	4

WGK Germany

Merck Index

155

Citations of This Product

1. Ziliang He, Yeye Hu, Ying Zhang, Jing Xie, Zhiqiang Niu, Guigui Yang, Ji Zhang, Zixuan Zhao, Shuai Wei, Haifeng Wu, Weicheng Hu. (2024) Asiaticoside exerts neuroprotection through targeting NLRP3 inflammasome activation. PHYTOMEDICINE, 127 (155494). [PMID:38471370] [10.1016/j.phymed.2024.155494]
2. Wang Hao, Zhuang Hui, Tang Wenjing, Zhu Jun, Zhu Wei, Jiang Lingxiang. (2024) Coacervate-pore complexes for selective molecular transport and dynamic reconfiguration. Nature Communications, 15 (1): (1-14). [PMID:39567561] [10.1038/s41467-024-54510-9]
3. Yi Duan, Mengqiong Deng, Bin Liu, Xianwei Meng, Jinghan Liao, Yijie Qiu, Zhihua Wu, Jiangtao Lin, Yi Dong, Yourong Duan, Ying Sun. (2024) Mitochondria targeted drug delivery system overcoming drug resistance in intrahepatic cholangiocarcinoma by reprogramming lipid metabolism. BIOMATERIALS, 309 (122609). [PMID:38754290] [10.1016/j.biomaterials.2024.122609]
4. Ya-Ling Chen, Yi Wang, Qiu-Yu Fang, Tong Wang, Cong Chen, Tong-Yao Gao, Ming Wu, Wei-Ping Zhang, Yun-Bi Lu. (2024) PARP-1 inhibitor alleviates cerebral ischemia/reperfusion injury by reducing PARylation of HK-1 and LDH in mice. EUROPEAN JOURNAL OF PHARMACOLOGY, 967 (176377). [PMID:38346469] [10.1016/j.ejphar.2024.176377]

References

1. Ziliang He, Yeye Hu, Ying Zhang, Jing Xie, Zhiqiang Niu, Guigui Yang, Ji Zhang, Zixuan Zhao, Shuai Wei, Haifeng Wu, Weicheng Hu. (2024) Asiaticoside exerts neuroprotection through targeting NLRP3 inflammasome activation. PHYTOMEDICINE, 127 (155494). [PMID:38471370] [10.1016/j.phymed.2024.155494]
2. Wang Hao, Zhuang Hui, Tang Wenjing, Zhu Jun, Zhu Wei, Jiang Lingxiang. (2024) Coacervate-pore complexes for selective molecular transport and dynamic reconfiguration. Nature Communications, 15 (1): (1-14). [PMID:39567561] [10.1038/s41467-024-54510-9]
3. Yi Duan, Mengqiong Deng, Bin Liu, Xianwei Meng, Jinghan Liao, Yijie Qiu, Zhihua Wu, Jiangtao Lin, Yi Dong, Yourong Duan, Ying Sun. (2024) Mitochondria targeted drug delivery system overcoming drug resistance in intrahepatic cholangiocarcinoma by reprogramming lipid metabolism. BIOMATERIALS, 309 (122609). [PMID:38754290] [10.1016/j.biomaterials.2024.122609]
4. Ya-Ling Chen, Yi Wang, Qiu-Yu Fang, Tong Wang, Cong Chen, Tong-Yao Gao, Ming Wu, Wei-Ping Zhang, Yun-Bi Lu. (2024) PARP-1 inhibitor alleviates cerebral ischemia/reperfusion injury by reducing PARylation of HK-1 and LDH in mice. EUROPEAN JOURNAL OF PHARMACOLOGY, 967 (176377). [PMID:38346469] [10.1016/j.ejphar.2024.176377]

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Basic Description