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BAY-u 9773 - A solution in ethanol, high purity , CAS No.154978-38-8, Antagonist of CysLT 1 receptor;Agonist of CysLT 2 receptor;Antagonist of CysLT 2 receptor

Moligand™

A solution in ethanol

CAS#: 154978-38-8
Molecular Weight: 472.64
PubChem CID: 5311015

In stock

Item Number

B331357

Grouped product items
SKU	Size	Availability	Price	Qty
B331357-50μg	50μg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$147.90

a cysteinyl leukotriene receptor antagonist

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Class A GPCR (4138) CysLT1 receptor Antagonist (17) CysLT2 receptor Agonist (7) CysLT2 receptor Antagonist (11) GPCR/G Protein (3172) Leukotriene Receptor (48)

Basic Description

Synonyms	Benzoic acid,4-[[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]thio]- \| HY-107609 \| Benzoic acid, 4-[[(1R,2E,4E,6Z,9Z)-1-[(1S)-4-carboxy-1-hydroxybutyl]-2,4,6,9-pentadecatetraen-1-yl]thio]- \| 6-(4'-carboxyphenylthio)-5-h
Specifications & Purity	Moligand™, A solution in ethanol
Storage Temp	Store at -80°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	AGONIST, ANTAGONIST
Mechanism of action	Antagonist of CysLT 1 receptor;Agonist of CysLT 2 receptor;Antagonist of CysLT 2 receptor
Product Description	BAY-u 9773 is a cysteinyl leukotriene receptor antagonist which displays equal affinity towards CysLT\|1\|and CysLT\|2\|receptors. This inhibitory action suppresses bronchial and venous muscle contractions in human muscle preparations. Alternate studies demonstrate that BAY-u 9773 inhibits eosinophil infiltration in airway walls. BAY-u 9773 inhibits water up-regulation by aquaporin 4, via antagonism of the CysLT\|2\|receptor. The permeability of cysteinyl leukotriene receptors across transendothelial membranes is reduced upon addition of BAY-u 9773. Furthermore,this compound acts as a competitive antagonist towards LTC\|4\|and LTE\|4\|receptors, which leads to contractions in trachea of guinea pig models.

Associated Targets(Human)

CYSLTR2 Tchem Cysteinyl leukotriene receptor 2 (4 Activities)

Discover Target: CYSLTR2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYSLTR1 Tclin Cysteinyl leukotriene receptor 1 (2 Activities)

Discover Target: CYSLTR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYSLTR1 Tclin Cysteinyl leukotriene receptor 1 (2118 Activities)

Discover Target: CYSLTR1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYSLTR2 Tchem Cysteinyl leukotriene receptor 2 (135 Activities)

Discover Target: CYSLTR2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Names and Identifiers

IUPAC Name	4-[(4S,5R,6E,8E,10Z,13Z)-1-carboxy-4-hydroxynonadeca-6,8,10,13-tetraen-5-yl]sulfanylbenzoic acid
INCHI	InChI=1S/C27H36O5S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(28)15-14-17-26(29)30)33-23-20-18-22(19-21-23)27(31)32/h6-7,9-13,16,18-21,24-25,28H,2-5,8,14-15,17H2,1H3,(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t24-,25+/m0/s1
InChi Key	PKJINWOACFYDQN-RBVMPENBSA-N
Canonical SMILES	CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SC1=CC=C(C=C1)C(=O)O
Isomeric SMILES	CCCCC/C=C\C/C=C\C=C\C=C\[C@H]([C@H](CCCC(=O)O)O)SC1=CC=C(C=C1)C(=O)O
WGK Germany	3
Alternate CAS	154978-38-8
PubChem CID	5311015
MeSH Entry Terms	6-(4'-carboxyphenylthio)-5-hydroxy-7,9,11,14-eicosatetraenoic acid;BAY u9773;BAY-u9773
Molecular Weight	472.64

Chemical and Physical Properties

Solubility	Soluble in ethanol (>25 mg/ml), water (0.15 mg/ml) at 25° C, DMSO (~25 mg/ml), DMF (~25 mg/ml), and PBS (pH 7.2) (~0.15 mg/ml).
Refractive Index	n20D1.59 (Predicted)
Boil Point(°C)	78° C
Melt Point(°C)	280.38° C (Predicted)
Molecular Weight	472.600 g/mol
XLogP3	6.700
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	17
Exact Mass	472.228 Da
Monoisotopic Mass	472.228 Da
Topological Polar Surface Area	120.000 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	659.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	4
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	4
Covalently-Bonded Unit Count	1

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BAY-u 9773 - A solution in ethanol, high purity , CAS No.154978-38-8, Antagonist of CysLT 1 receptor;Agonist of CysLT 2 receptor;Antagonist of CysLT 2 receptor

Basic Description

Product Properties

Associated Targets(Human)

Mechanisms of Action

Names and Identifiers

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Chemical and Physical Properties

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