Skip to the beginning of the images gallery

BIX 02188 - ≥98%, high purity , CAS No.1094614-84-2, Inhibitor of mitogen-activated protein kinase 7;Inhibitor of mitogen-activated protein kinase kinase 5

≥98%

CAS#: 1094614-84-2
Molecular Weight: 412.48
PubChem CID: 135398492

In stock

Item Number

B129583

Grouped product items
SKU	Size	Availability	Price
B129583-5mg	5mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$162.90
B129583-10mg	10mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$301.90
B129583-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$909.90

View related series

mitogen-activated protein kinase 7 Inhibitor (8) mitogen-activated protein kinase kinase 5 Inhibitor (2)

Synonyms	AC-28462 \| (3Z)-3-[[3-[(dimethylamino)methyl]anilino]-phenylmethylidene]-2-oxo-1H-indole-6-carboxamide \| SB19418 \| 1094614-84-2 \| SCHEMBL16685266 \| Luf-Iso (TN) \| 1H-INDOLE-6-CARBOXAMIDE, 3-(((3-((DIMETHYLAMINO)METHYL)PHENYL)AMINO)PHENYLMETHYLENE)-2,3-DIH
Specifications & Purity	Moligand™, ≥98%
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Inhibitor of mitogen-activated protein kinase 7;Inhibitor of mitogen-activated protein kinase kinase 5
Product Description	BIX02188 is a selective inhibitor of MEK5 with IC50 of 4.3 nM, also inhibits ERK5 catalytic activity with IC50 of 810 nM, and does not inhibit closely related kinases MEK1, MEK2, ERK2, and JNK2.

IUPAC Name	3-[N-[3-[(dimethylamino)methyl]phenyl]-C-phenylcarbonimidoyl]-2-hydroxy-1H-indole-6-carboxamide
INCHI	InChI=1S/C25H24N4O2/c1-29(2)15-16-7-6-10-19(13-16)27-23(17-8-4-3-5-9-17)22-20-12-11-18(24(26)30)14-21(20)28-25(22)31/h3-14,28,31H,15H2,1-2H3,(H2,26,30)
InChi Key	WGPXKFOFEXJMBD-UHFFFAOYSA-N
Canonical SMILES	CN(C)CC1=CC(=CC=C1)N=C(C2=CC=CC=C2)C3=C(NC4=C3C=CC(=C4)C(=O)N)O
Isomeric SMILES	CN(C)CC1=CC(=CC=C1)N=C(C2=CC=CC=C2)C3=C(NC4=C3C=CC(=C4)C(=O)N)O
PubChem CID	135398492
Molecular Weight	412.48

Solubility	DMSO 43 mg/mL Water <1 mg/mL Ethanol 3 mg/mL
Molecular Weight	412.500 g/mol
XLogP3	3.900
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	412.19 Da
Monoisotopic Mass	412.19 Da
Topological Polar Surface Area	94.700 Å²
Heavy Atom Count	31
Formal Charge	0
Complexity	645.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

BIX 02188 - ≥98%, high purity , CAS No.1094614-84-2, Inhibitor of mitogen-activated protein kinase 7;Inhibitor of mitogen-activated protein kinase kinase 5

Basic Description

Associated Targets(Human)

Associated Targets(non-human)

Mechanisms of Action

Names and Identifiers

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

Chemical and Physical Properties

Specifications

Citations of This Product

References

Solution Calculators

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Reviews

Customer Reviews

1. Tatake RJ, O'Neill MM, Kennedy CA, Wayne AL, Jakes S, Wu D, Kugler Jr SZ, Kashem MA, Kaplita P, Snow RJ. (2008) Identification of pharmacological inhibitors of the MEK5/ERK5 pathway.. Biochem Biophys Res Commun, 377 (1): (120-5). [PMID:18834865] [10.1021/op500134e]
2. Zhaohui Xue, Xin Gao, Wancong Yu, Qian Zhang, Weichen Song, Shihao Li, Xu Zheng, Xiaohong Kou. (2021) Biochanin A alleviates oxidative damage caused by the urban particulate matter. Food & Function, 12 (5): (1958-1972). [PMID:33496707] [10.1039/D0FO02582H]