Blinatumomab (anti-CD3&CD19) is a bispecific monoclonal antibody which can specifically targets the CD19 antigen present on B cells. Blinatumomab (anti-CD3&CD19) can be used for the research of acute lymphoblastic leukemia. Purity ≥95% (SDS-PAGE&SEC) Endotoxin Level ≤1.0EU/mg
Product Properties
Light Chain Type
kappa
SDS-PAGE
54.05 kDa
Purification Method
Nickel affinity chromatography+Molecular sieve
Shape
Liquid
Concentration
See COA
Storage Temp
Store at -80°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
1.Mølhøj M, Crommer S, Brischwein K, Rau D, Sriskandarajah M, Hoffmann P, Kufer P, Hofmeister R, Baeuerle PA. (2007) CD19-/CD3-bispecific antibody of the BiTE class is far superior to tandem diabody with respect to redirected tumor cell lysis.. Mol Immunol, 44 (8):(1935-43). [PMID:17083975][10.1021/op500134e]
2.Brischwein K, Parr L, Pflanz S, Volkland J, Lumsden J, Klinger M, Locher M, Hammond SA, Kiener P, Kufer P et al.. (2007) Strictly target cell-dependent activation of T cells by bispecific single-chain antibody constructs of the BiTE class.. J Immunother, 30 (8):(798-807). [PMID:18049331][10.1021/op500134e]
3.Aldoss I, Bargou RC, Nagorsen D, Friberg GR, Baeuerle PA, Forman SJ. (2017) Redirecting T cells to eradicate B-cell acute lymphoblastic leukemia: bispecific T-cell engagers and chimeric antigen receptors.. Leukemia, 31 (4):(777-787). [PMID:28028314][10.1021/op500134e]
4.Gökbuget N, Dombret H, Bonifacio M, Reichle A, Graux C, Faul C, Diedrich H, Topp MS, Brüggemann M, Horst HA et al.. (2018) Blinatumomab for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukemia.. Blood, 131 (14):(1522-1531). [PMID:29358182][10.1021/op500134e]
5.Slaney CY, Wang P, Darcy PK, Kershaw MH. (2018) CARs versus BiTEs: A Comparison between T Cell-Redirection Strategies for Cancer Treatment.. Cancer Discov, 8 (8):(924-934). [PMID:30012854][10.1021/op500134e]
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