Carotuximab (anti-CD105) - Primary antibody, specific to ENG, >95%, high purity, Human IgG1, Antibody of endoglin (CD105), Antibody of endoglin (CD105)

    Application:
  • Animal Model
  • ELISA
  • Flow Cytometry
  • Functional Assay
Features and benefits
  • Host species: Human
  • Species reactivity(Reacts with): Cynomolgus monkey,Human
  • Isotype: Human IgG1
  • Conjugation: Unconjugated
In stock
Item Number
Ab175487
Grouped product items
SKUSizeAvailabilityPrice Qty
Ab175487-100μg
100μg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$59.90
Ab175487-1mg
1mg
5
$259.90
Ab175487-5mg
5mg
1
$749.90
Ab175487-10mg
10mg
Available within 8-12 weeks(?)
Production requires sourcing of materials. We appreciate your patience and understanding.
$1,189.90

Purity>95% (SDS-PAGE&SEC); Endotoxin Level<1.0EU/mg; Human IgG1; CHO; ELISA, FACS, Functional assay, Animal Model; Unconjugated

Basic Description

Product NameCarotuximab (anti-CD105) - Primary antibody, specific to ENG, >95%, high purity, Human IgG1, Antibody of endoglin (CD105)
SynonymsAI528660 antibody | AI662476 antibody | CD 105 antibody | CD105 antibody | CD105 antigen antibody | EGLN_HUMAN antibody | END antibody | Endoglin antibody | Eng antibody | FLJ41744 antibody | HHT1 antibody | ORW antibody | ORW1 antibody | Osler Rendu Webe
Specifications & PurityCarrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, ≥95%(SDS-PAGE&SEC-HPLC), See COA
Host speciesHuman
SpecificityENG
ConjugationUnconjugated
GradeAzide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated
Action TypeINHIBITOR
Mechanism of actionAntibody of endoglin (CD105)
Product Description

Carotuximab (anti-CD105) is a IgG1 monoclonal antibody that blocks endoglin (CD105) and its downstream Smad signaling pathway. Carotuximab (anti-CD105) has immunomodulatory and antineoplastic actions.

Product Properties

IsotypeHuman IgG1
Light Chain Typekappa
SDS-PAGE25.8 kDa (Light Chain) & 49.7 kDa (Heavy Chain), under reducing conditions; 191.0 kDa, under non-reducing conditions.
Purification MethodProtein A purified
Purity>95%
ShapeLiquid
ConcentrationSee COA
Storage TempStore at -80°C,Avoid repeated freezing and thawing
Shipped InIce chest + Ice pads
Stability And StorageStore at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS1268714-50-6

Images

Carotuximab (anti-CD105) (Ab175487) - Flow Cytometry
Flow Cytometry analysis of HUVEC cells labelling CD105 (red) with Carotuximab (anti-CD105) (Ab175487). Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

Carotuximab (anti-CD105) (Ab175487) - SEC
The purity of Carotuximab (anti-CD105) (Ab175487) is more than 95% verified by HPLC.

Carotuximab (anti-CD105) (Ab175487) - ELISA
Immobilized Recombinant human CD105 protein (rp169605) at 1.0 μg/mL can bind Carotuximab (anti-CD105) (Ab175487) with the EC50 of 31.4 ng/mL.

Associated Targets(Human)

ENG Tbio Endoglin (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Mechanisms of Action

Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

3 results found

Lot NumberCertificate TypeDateItem
ZJ24F0607384Certificate of AnalysisJun 26, 2024 Ab175487
ZJ23F1202227Certificate of AnalysisDec 26, 2023 Ab175487
ZJ23F1202228Certificate of AnalysisDec 26, 2023 Ab175487

Specifications

References

1. Cheifetz, S S and 6 more authors..  (1992)  Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells..  The Journal of biological chemistry,    (25):   [PMID:1326540]
2. Gougos, A A and Letarte, M M..  (1990)  Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells..  The Journal of biological chemistry,    (25):   [PMID:1692830]
3. McAllister, K A KA and 9 more authors..  (1994)  Endoglin, a TGF-beta binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1..  Nature genetics,      [PMID:7894484]
4. Bellón, T T and 9 more authors..  (1993)  Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions..  European journal of immunology,      [PMID:8370410]
5. Yamaguchi, H H, Azuma, H H, Shigekiyo, T T, Inoue, H H and Saito, S S..  (1997)  A novel missense mutation in the endoglin gene in hereditary hemorrhagic telangiectasia..  Thrombosis and haemostasis,      [PMID:9157574]
6. Shovlin, C L CL, Hughes, J M JM, Scott, J J, Seidman, C E CE and Seidman, J G JG..  (1997)  Characterization of endoglin and identification of novel mutations in hereditary hemorrhagic telangiectasia..  American journal of human genetics,      [PMID:9245986]
7. Gallione, C J CJ and 18 more authors..  (1998)  Mutation and expression analysis of the endoglin gene in hereditary hemorrhagic telangiectasia reveals null alleles..  Human mutation,      [PMID:9554745]
8. Pece-Barbara, N N, Cymerman, U U, Vera, S S, Marchuk, D A DA and Letarte, M M..  (1999)  Expression analysis of four endoglin missense mutations suggests that haploinsufficiency is the predominant mechanism for hereditary hemorrhagic telangiectasia type 1..  Human molecular genetics,      [PMID:10545596]
9. Cymerman, U U and 6 more authors..  (2000)  Identification of hereditary hemorrhagic telangiectasia type 1 in newborns by protein expression and mutation analysis of endoglin..  Pediatric research,      [PMID:10625079]
10. Gallione, C J CJ and 6 more authors..  (2000)  Two common endoglin mutations in families with hereditary hemorrhagic telangiectasia in the Netherlands Antilles: evidence for a founder effect..  Human genetics,      [PMID:10982033]
11. Lesca, Gaëtan G and 15 more authors..  (2004)  Molecular screening of ALK1/ACVRL1 and ENG genes in hereditary hemorrhagic telangiectasia in France..  Human mutation,      [PMID:15024723]
12. Kuehl, Heidi K A HK and 6 more authors..  (2005)  Hepatic manifestation is associated with ALK1 in hereditary hemorrhagic telangiectasia: identification of five novel ALK1 and one novel ENG mutations..  Human mutation,      [PMID:15712270]
13. Argyriou, Loukas L and 6 more authors..  (2006)  Novel mutations in the ENG and ACVRL1 genes causing hereditary hemorrhagic teleangiectasia..  International journal of molecular medicine,      [PMID:16525724]
14. Bossler, Aaron D AD, Richards, Jennifer J, George, Cicily C, Godmilow, Lynn L and Ganguly, Arupa A..  (2006)  Novel mutations in ENG and ACVRL1 identified in a series of 200 individuals undergoing clinical genetic testing for hereditary hemorrhagic telangiectasia (HHT): correlation of genotype with phenotype..  Human mutation,      [PMID:16752392]
15. Meng, Qingjun Q and 10 more authors..  (2006)  Identification of Tctex2beta, a novel dynein light chain family member that interacts with different transforming growth factor-beta receptors..  The Journal of biological chemistry,    (1):   [PMID:16982625]
16. Lee, Nam Y NY and Blobe, Gerard C GC..  (2007)  The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells..  The Journal of biological chemistry,    (20):   [PMID:17540773]
17. Richards-Yutz, Jennifer J, Grant, Kathleen K, Chao, Elizabeth C EC, Walther, Susan E SE and Ganguly, Arupa A..  (2010)  Update on molecular diagnosis of hereditary hemorrhagic telangiectasia..  Human genetics,      [PMID:20414677]
18. Castonguay, Roselyne R and 11 more authors..  (2011)  Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth..  The Journal of biological chemistry,    (26):   [PMID:21737454]
19. Alt, Aaron A and 8 more authors..  (2012)  Structural and functional insights into endoglin ligand recognition and binding..  PloS one,      [PMID:22347366]
20. Nolan-Stevaux, Olivier O and 6 more authors..  (2012)  Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies..  PloS one,      [PMID:23300529]
21. Saito, Takako T and 7 more authors..  (2017)  Structural Basis of the Human Endoglin-BMP9 Interaction: Insights into BMP Signaling and HHT1..  Cell reports,    (30):   [PMID:28564608]

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