Basic Description

Synonyms	F0001-1737 \| Diethyl sulphate \| NCGC00164138-01 \| SCHEMBL1769 \| UN 1594 \| BCP25766 \| DIETHYL SULFATE [MI] \| DIETHYLSULFATE \| Sulfuric acid, diethyl ester \| Diaethylsulfat [German] \| DTXSID1024045 \| InChI=1/C4H10O4S/c1-3-7-9(5,6)8-4-2/h3-4H2,1-2H \| J-52030
Specifications & Purity	≥99%(GC)
Storage Temp	Protected from light,Desiccated
Shipped In	Normal

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504751013
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504751013
IUPAC Name	diethyl sulfate
INCHI	InChI=1S/C4H10O4S/c1-3-7-9(5,6)8-4-2/h3-4H2,1-2H3
InChi Key	DENRZWYUOJLTMF-UHFFFAOYSA-N
Canonical SMILES	CCOS(=O)(=O)OCC
Isomeric SMILES	CCOS(=O)(=O)OCC
WGK Germany	3
RTECS	WS7875000
UN Number	1594
Packing Group	II
Molecular Weight	154.18
Beilstein	1209714
Reaxy-Rn	1209714
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1209714&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

8 results found

Lot Number	Certificate Type	Date	Item
I2320505	Certificate of Analysis	Sep 12, 2023	D110632
I2320506	Certificate of Analysis	Sep 12, 2023	D110632
I2320507	Certificate of Analysis	Sep 12, 2023	D110632
L2427158	Certificate of Analysis	Sep 12, 2023	D110632
F2221029	Certificate of Analysis	Jun 08, 2022	D110632
F2221040	Certificate of Analysis	Jun 08, 2022	D110632
F2221030	Certificate of Analysis	Jun 08, 2022	D110632
F2221025	Certificate of Analysis	Jun 08, 2022	D110632

Chemical and Physical Properties

Sensitivity	Light & Moisture sensitive.
Refractive Index	1.40037
Flash Point(°F)	219.2 °F
Flash Point(°C)	140.4℃
Boil Point(°C)	209.5°C
Melt Point(°C)	-25°C
Molecular Weight	154.190 g/mol
XLogP3	1.100
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	4
Exact Mass	154.03 Da
Monoisotopic Mass	154.03 Da
Topological Polar Surface Area	61.000 Å²
Heavy Atom Count	9
Formal Charge	0
Complexity	130.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Safety and Hazards(GHS)

Pictogram(s)	GHS06, GHS08, GHS05
Signal	Danger
Hazard Statements	H314:Causes severe skin burns and eye damage H302:Harmful if swallowed H312:Harmful in contact with skin H332:Harmful if inhaled H340:May cause genetic defects H350:May cause cancer
Precautionary Statements	P261:Avoid breathing dust/fume/gas/mist/vapors/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of water. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P281:Use personal protective equipment as required. P271:Use only outdoors or in a well-ventilated area. P270:Do not eat, drink or smoke when using this product. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P362+P364:Take off contaminated clothing and wash it before reuse. P330:Rinse mouth. P203:Obtain, read and follow all safety instructions before use. P301+P317:IF SWALLOWED: Get medical help. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P318:if exposed or concerned, get medical advice. P317:Get emergency medical help. P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes. P316:Get emergency medical help immediately.
WGK Germany	3
RTECS	WS7875000
Reaxy-Rn	1209714
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1209714&ln=
Class	6.1
Merck Index	3130

Specifications

Density (20°C)	1.178-1.182
Refractive index n20/D	1.399-1.402
Purity(GC)	99-100（%）
Appearance（D110632)	Colorless Liquid
Infrared spectrum	Conforms to Structure
Proton NMR spectrum	Conforms to Structure

Specification Sheet

Alternative Products

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Fang Li, Min Zhu, Zimu Li, Nuotong Shen, Hao Peng, Bing Li, Jianbo He. (2024) Machine learning assisted discrimination and detection of antibiotics by using multicolor microfluidic chemiluminescence detection chip. TALANTA, 269 (5): (125446). [PMID:38043343] [10.1016/j.talanta.2023.125446]
2. Xiaohuan Zang, Qingyun Chang, Fangyuan Hou, Shuaihua Zhang, Chun Wang, Zhi Wang, Jianzhong Xu. (2024) Hydroxyl and carboxyl group functionalized conjugated microporous nanomaterial as adsorbent for the solid-phase extraction of phenolic endocrine disrupting chemicals from freshwater fish samples. FOOD CHEMISTRY, 436 (16): (137674). [PMID:37832421] [10.1016/j.foodchem.2023.137674]
3. Teng Yuanjie, Li Xin, Chen Yingxin, Xu Pei, Pan Zaifa, Shao Kang, Sun Nan. (2023) Cucurbit[8]uril-mediated SERS plasmonic nanostructures with sub-nanometer gap for the identification and determination of estrogens. MICROCHIMICA ACTA, 190 (5): (1-10). [PMID:37071210] [10.1007/s00604-023-05765-4]
4. Xuhong Cai, Junbo Liu, Dadong Liang, Shanshan Tang, Bao Xu. (2023) Construction of a QCM sensor for detecting diethylstilbestrol in water based on the computational design of molecularly imprinted polymers. Arabian Journal of Chemistry, 16 (104601). [PMID:] [10.1016/j.arabjc.2023.104601]
5. Qiangbing Shi, Kaixuan Wang, Mengjun Wang, Tao Li, Baozeng Ren, Yinge Bai, Xiangping Zhang. (2022) Efficient Recovery of Dichloromethane from Tail Gas by 1-Alkyl-2-ethylimidazole Ethyl Sulfate and 1-Ethylpyridine Ethyl Sulfate. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 61 (34): (12699–12709). [PMID:] [10.1021/acs.iecr.2c00955]
6. Yan Du, Xiaohui Yan, Yuanbo Chen, Yi Wu, Qiankun Qiu, Yanshuo Li, Dapeng Wu. (2022) Magnetic polyimide nanosheet microspheres for trace analysis of estrogens in aqueous samples by magnetic solid-phase extraction-gas chromatography–mass spectrometry. JOURNAL OF CHROMATOGRAPHY A, 1675 (463184). [PMID:35675733] [10.1016/j.chroma.2022.463184]
7. Jizhong Wu, Waqas Ahmad, Qin Ouyang, Jingui Zhang, Mingming Zhang, Quansheng Chen. (2021) Regenerative Flexible Upconversion-Luminescence Biosensor for Visual Detection of Diethylstilbestrol Based on Smartphone Imaging. ANALYTICAL CHEMISTRY, 93 (47): (15667–15676). [PMID:34787394] [10.1021/acs.analchem.1c03325]
8. Zhong ZhenHua, Chen YuPing, Xia HongYing, Chen ZhenZhen, Cheng QiZhen. (2021) Development and Validation of a Sensitive GC–MS/MS Method for the Determination of Five Potential Genotoxic Impurities in Abiraterone Acetate. JOURNAL OF CHROMATOGRAPHIC SCIENCE, 60 (2): (105-110). [PMID:34059885] [10.1093/chromsci/bmab052]
9. Junquan Wu, Xiaojuan Zhao, Yuting Zou, Xiaochun Wu, Weidong Bai, Xiaofang Zeng. (2021) Electrochemical determination of diethylstilbestrol in livestock and poultry meats by L-cysteine/gold nanoparticles modified electrode. MICROCHEMICAL JOURNAL, 164 (105952). [PMID:] [10.1016/j.microc.2021.105952]
10. Ming-Zhu Gao, Qi Cui, Li-Tao Wang, Yao Meng, Lian Yu, Yan-Yan Li, Yu-Jie Fu. (2020) A green and integrated strategy for enhanced phenolic compounds extraction from mulberry (Morus alba L.) leaves by deep eutectic solvent. MICROCHEMICAL JOURNAL, 154 (104598). [PMID:] [10.1016/j.microc.2020.104598]
11. Jun Cao, Rong Wu, Qihui Dong, Linguo Zhao, Fuliang Cao, Erzheng Su. (2019) Effective Release of Intracellular Enzymes by Permeating the Cell Membrane with Hydrophobic Deep Eutectic Solvents. CHEMBIOCHEM, 21 (5): (672-680). [PMID:31535442] [10.1002/cbic.201900502]
12. Chi Li, Yuanyuan Zhang, Ting Zeng, Xinyue Chen, Wenqian Wang, Qijin Wan, Nianjun Yang. (2019) Graphene nanoplatelet supported CeO2 nanocomposites towards electrocatalytic oxidation of multiple phenolic pollutants. ANALYTICA CHIMICA ACTA, 1088 (45). [PMID:31623715] [10.1016/j.aca.2019.08.024]
13. Zhang Yu, Zhang Xiaohuan, Xiao Shiyuan, Qi Wei, Xu Jingliang, Yuan Zhenhong, Wang Zhongming. (2019) Engineering Corynebacterium glutamicum Mutants for 3-Methyl-1-butanol Production. BIOCHEMICAL GENETICS, 57 (3): (443-454). [PMID:30644007] [10.1007/s10528-019-09906-4]
14. Lei Chen, Mingyue Zhang, Fengfu Fu, Jingguang Li, Zian Lin. (2018) Facile synthesis of magnetic covalent organic framework nanobeads and application to magnetic solid-phase extraction of trace estrogens from human urine. JOURNAL OF CHROMATOGRAPHY A, 1567 (136). [PMID:30100013] [10.1016/j.chroma.2018.06.066]
15. Xiaoman Chen, Zhaoxia Shi, Yufei Hu, Xiaohua Xiao, Gongke Li. (2018) A novel electrochemical sensor based on Fe3O4-doped nanoporous carbon for simultaneous determination of diethylstilbestrol and 17β-estradiol in toner. TALANTA, 188 (81). [PMID:30029450] [10.1016/j.talanta.2018.05.063]
16. Chunxi Zhao, Yang Jiao, Lei Zhang, Yaling Yang. (2018) One-step synthesis of S,B co-doped carbon dots and their application for selective and sensitive fluorescence detection of diethylstilbestrol. NEW JOURNAL OF CHEMISTRY, 42 (4): (2857-2864). [PMID:] [10.1039/C7NJ04983H]
17. Wei Liu, Yanyan Lv, Shuai Tian, Mengwei Zhang, Ting Shu, Nan Hu, Zhaoliang Wu. (2018) Foam fractionation for effective recovery of resveratrol from the leaching liquor of Polygonum cuspidatum by using partially ethylated β-cyclodextrin as collector and frother. INDUSTRIAL CROPS AND PRODUCTS, 112 (420). [PMID:] [10.1016/j.indcrop.2017.12.035]
18. Li Junhua, Jiang Jianbo, Xu Zhifeng, Liu Mengqin, Feng Haibo, Liu Youcai, Qian Dong. (2017) Synthesis of a nanocomposite consisting of Cu2O and N-doped reduced graphene oxide with enhanced electrocatalytic activity for amperometric determination of diethylstilbestrol. MICROCHIMICA ACTA, 184 (11): (4331-4339). [PMID:] [10.1007/s00604-017-2452-4]
19. Zhang Dai, Zhou Lifang, Lei Yajing, Zhou Zhan, Zhou Jie, Chen Shuqing. (2017) Investigation of diethylstilbestrol residue level in human urine samples by a specific monoclonal antibody. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 24 (8): (7042-7050). [PMID:28092005] [10.1007/s11356-017-8405-y]
20. Xie Xiaoyu, Pan Xiaoyan, Han Shengli, Wang Sicen. (2015) Development and characterization of magnetic molecularly imprinted polymers for the selective enrichment of endocrine disrupting chemicals in water and milk samples. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 407 (6): (1735-1744). [PMID:25577356] [10.1007/s00216-014-8425-0]
21. Jieming Dong, Junyao Li, Laidi Xu, Hongyu Zhang, Yong Kong, Guojun Zheng. (2025) A molecularly imprinted electrochemical sensor based on Au nanoparticles-poly(o-phenylenediamine) for diethylstilbestrol detection. SYNTHETIC METALS, 311 (117814). [PMID:] [10.1016/j.synthmet.2024.117814]
22. Dongmei Li, Jiayue Zhou, Zhuxin Chang, Hongwei Zhao, Nan Zhang, Huan Xia, Linyuan Wang, Jie Zhao, Guanggui Yu, Zhongze Fang, Na Sai. (2025) Chameleon-inspired molecular imprinted polymer with bicolored states for visual and stable detection of diethylstilbestrol in water and food samples. FOOD CHEMISTRY, 469 (142531). [PMID:39729655] [10.1016/j.foodchem.2024.142531]
23. Ning Li, Chenxi Ren, Qin Hu, Bo Wang, Zhenquan Yang, Lixia Xiao, Tianzhu Guan. (2025) Multiplex aptamer cluster detection platform and systems toxicology study for 17β-estradiol, bisphenol A, and diethylstilbestrol. FOOD CHEMISTRY, 463 (141395). [PMID:39340920] [10.1016/j.foodchem.2024.141395]

References

1. Fang Li, Min Zhu, Zimu Li, Nuotong Shen, Hao Peng, Bing Li, Jianbo He. (2024) Machine learning assisted discrimination and detection of antibiotics by using multicolor microfluidic chemiluminescence detection chip. TALANTA, 269 (5): (125446). [PMID:38043343] [10.1016/j.talanta.2023.125446]
2. Xiaohuan Zang, Qingyun Chang, Fangyuan Hou, Shuaihua Zhang, Chun Wang, Zhi Wang, Jianzhong Xu. (2024) Hydroxyl and carboxyl group functionalized conjugated microporous nanomaterial as adsorbent for the solid-phase extraction of phenolic endocrine disrupting chemicals from freshwater fish samples. FOOD CHEMISTRY, 436 (16): (137674). [PMID:37832421] [10.1016/j.foodchem.2023.137674]
3. Teng Yuanjie, Li Xin, Chen Yingxin, Xu Pei, Pan Zaifa, Shao Kang, Sun Nan. (2023) Cucurbit[8]uril-mediated SERS plasmonic nanostructures with sub-nanometer gap for the identification and determination of estrogens. MICROCHIMICA ACTA, 190 (5): (1-10). [PMID:37071210] [10.1007/s00604-023-05765-4]
4. Xuhong Cai, Junbo Liu, Dadong Liang, Shanshan Tang, Bao Xu. (2023) Construction of a QCM sensor for detecting diethylstilbestrol in water based on the computational design of molecularly imprinted polymers. Arabian Journal of Chemistry, 16 (104601). [PMID:] [10.1016/j.arabjc.2023.104601]
5. Qiangbing Shi, Kaixuan Wang, Mengjun Wang, Tao Li, Baozeng Ren, Yinge Bai, Xiangping Zhang. (2022) Efficient Recovery of Dichloromethane from Tail Gas by 1-Alkyl-2-ethylimidazole Ethyl Sulfate and 1-Ethylpyridine Ethyl Sulfate. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 61 (34): (12699–12709). [PMID:] [10.1021/acs.iecr.2c00955]
6. Yan Du, Xiaohui Yan, Yuanbo Chen, Yi Wu, Qiankun Qiu, Yanshuo Li, Dapeng Wu. (2022) Magnetic polyimide nanosheet microspheres for trace analysis of estrogens in aqueous samples by magnetic solid-phase extraction-gas chromatography–mass spectrometry. JOURNAL OF CHROMATOGRAPHY A, 1675 (463184). [PMID:35675733] [10.1016/j.chroma.2022.463184]
7. Jizhong Wu, Waqas Ahmad, Qin Ouyang, Jingui Zhang, Mingming Zhang, Quansheng Chen. (2021) Regenerative Flexible Upconversion-Luminescence Biosensor for Visual Detection of Diethylstilbestrol Based on Smartphone Imaging. ANALYTICAL CHEMISTRY, 93 (47): (15667–15676). [PMID:34787394] [10.1021/acs.analchem.1c03325]
8. Zhong ZhenHua, Chen YuPing, Xia HongYing, Chen ZhenZhen, Cheng QiZhen. (2021) Development and Validation of a Sensitive GC–MS/MS Method for the Determination of Five Potential Genotoxic Impurities in Abiraterone Acetate. JOURNAL OF CHROMATOGRAPHIC SCIENCE, 60 (2): (105-110). [PMID:34059885] [10.1093/chromsci/bmab052]
9. Junquan Wu, Xiaojuan Zhao, Yuting Zou, Xiaochun Wu, Weidong Bai, Xiaofang Zeng. (2021) Electrochemical determination of diethylstilbestrol in livestock and poultry meats by L-cysteine/gold nanoparticles modified electrode. MICROCHEMICAL JOURNAL, 164 (105952). [PMID:] [10.1016/j.microc.2021.105952]
10. Ming-Zhu Gao, Qi Cui, Li-Tao Wang, Yao Meng, Lian Yu, Yan-Yan Li, Yu-Jie Fu. (2020) A green and integrated strategy for enhanced phenolic compounds extraction from mulberry (Morus alba L.) leaves by deep eutectic solvent. MICROCHEMICAL JOURNAL, 154 (104598). [PMID:] [10.1016/j.microc.2020.104598]
11. Jun Cao, Rong Wu, Qihui Dong, Linguo Zhao, Fuliang Cao, Erzheng Su. (2019) Effective Release of Intracellular Enzymes by Permeating the Cell Membrane with Hydrophobic Deep Eutectic Solvents. CHEMBIOCHEM, 21 (5): (672-680). [PMID:31535442] [10.1002/cbic.201900502]
12. Chi Li, Yuanyuan Zhang, Ting Zeng, Xinyue Chen, Wenqian Wang, Qijin Wan, Nianjun Yang. (2019) Graphene nanoplatelet supported CeO2 nanocomposites towards electrocatalytic oxidation of multiple phenolic pollutants. ANALYTICA CHIMICA ACTA, 1088 (45). [PMID:31623715] [10.1016/j.aca.2019.08.024]
13. Zhang Yu, Zhang Xiaohuan, Xiao Shiyuan, Qi Wei, Xu Jingliang, Yuan Zhenhong, Wang Zhongming. (2019) Engineering Corynebacterium glutamicum Mutants for 3-Methyl-1-butanol Production. BIOCHEMICAL GENETICS, 57 (3): (443-454). [PMID:30644007] [10.1007/s10528-019-09906-4]
14. Lei Chen, Mingyue Zhang, Fengfu Fu, Jingguang Li, Zian Lin. (2018) Facile synthesis of magnetic covalent organic framework nanobeads and application to magnetic solid-phase extraction of trace estrogens from human urine. JOURNAL OF CHROMATOGRAPHY A, 1567 (136). [PMID:30100013] [10.1016/j.chroma.2018.06.066]
15. Xiaoman Chen, Zhaoxia Shi, Yufei Hu, Xiaohua Xiao, Gongke Li. (2018) A novel electrochemical sensor based on Fe3O4-doped nanoporous carbon for simultaneous determination of diethylstilbestrol and 17β-estradiol in toner. TALANTA, 188 (81). [PMID:30029450] [10.1016/j.talanta.2018.05.063]
16. Chunxi Zhao, Yang Jiao, Lei Zhang, Yaling Yang. (2018) One-step synthesis of S,B co-doped carbon dots and their application for selective and sensitive fluorescence detection of diethylstilbestrol. NEW JOURNAL OF CHEMISTRY, 42 (4): (2857-2864). [PMID:] [10.1039/C7NJ04983H]
17. Wei Liu, Yanyan Lv, Shuai Tian, Mengwei Zhang, Ting Shu, Nan Hu, Zhaoliang Wu. (2018) Foam fractionation for effective recovery of resveratrol from the leaching liquor of Polygonum cuspidatum by using partially ethylated β-cyclodextrin as collector and frother. INDUSTRIAL CROPS AND PRODUCTS, 112 (420). [PMID:] [10.1016/j.indcrop.2017.12.035]
18. Li Junhua, Jiang Jianbo, Xu Zhifeng, Liu Mengqin, Feng Haibo, Liu Youcai, Qian Dong. (2017) Synthesis of a nanocomposite consisting of Cu2O and N-doped reduced graphene oxide with enhanced electrocatalytic activity for amperometric determination of diethylstilbestrol. MICROCHIMICA ACTA, 184 (11): (4331-4339). [PMID:] [10.1007/s00604-017-2452-4]
19. Zhang Dai, Zhou Lifang, Lei Yajing, Zhou Zhan, Zhou Jie, Chen Shuqing. (2017) Investigation of diethylstilbestrol residue level in human urine samples by a specific monoclonal antibody. ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 24 (8): (7042-7050). [PMID:28092005] [10.1007/s11356-017-8405-y]
20. Xie Xiaoyu, Pan Xiaoyan, Han Shengli, Wang Sicen. (2015) Development and characterization of magnetic molecularly imprinted polymers for the selective enrichment of endocrine disrupting chemicals in water and milk samples. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 407 (6): (1735-1744). [PMID:25577356] [10.1007/s00216-014-8425-0]
21. Jieming Dong, Junyao Li, Laidi Xu, Hongyu Zhang, Yong Kong, Guojun Zheng. (2025) A molecularly imprinted electrochemical sensor based on Au nanoparticles-poly(o-phenylenediamine) for diethylstilbestrol detection. SYNTHETIC METALS, 311 (117814). [PMID:] [10.1016/j.synthmet.2024.117814]
22. Dongmei Li, Jiayue Zhou, Zhuxin Chang, Hongwei Zhao, Nan Zhang, Huan Xia, Linyuan Wang, Jie Zhao, Guanggui Yu, Zhongze Fang, Na Sai. (2025) Chameleon-inspired molecular imprinted polymer with bicolored states for visual and stable detection of diethylstilbestrol in water and food samples. FOOD CHEMISTRY, 469 (142531). [PMID:39729655] [10.1016/j.foodchem.2024.142531]
23. Ning Li, Chenxi Ren, Qin Hu, Bo Wang, Zhenquan Yang, Lixia Xiao, Tianzhu Guan. (2025) Multiplex aptamer cluster detection platform and systems toxicology study for 17β-estradiol, bisphenol A, and diethylstilbestrol. FOOD CHEMISTRY, 463 (141395). [PMID:39340920] [10.1016/j.foodchem.2024.141395]

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SKU	Size	Availability	Price	Qty
D110632-100ml	100ml	3	$13.90
D110632-500ml	500ml	3	$31.90

Diethyl sulfate - >99.0%(GC), high purity , CAS No.64-67-5