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Immunoglobulin C1-set domain-containing proteins
efgartigimod alfa, Antibody of Fc fragment of IgG receptor and transporter, Antibody of Fc fragment of IgG receptor and transporter

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efgartigimod alfa, Antibody of Fc fragment of IgG receptor and transporter, Antibody of Fc fragment of IgG receptor and transporter

Moligand™

Features and benefits

In stock

Item Number

Ab175520

Grouped product items
SKU	Size	Availability	Price	Qty
Ab175520-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$2,668.90
Ab175520-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$4,668.90

View related series

Click to view target information: FCGRT

Fc fragment of IgG receptor and transporter Antibody (4)

Basic Description

Product Name	efgartigimod alfa, Antibody of Fc fragment of IgG receptor and transporter
Specifications & Purity	Moligand™
Grade	Moligand™
Action Type	ANTAGONIST
Mechanism of action	Antibody of Fc fragment of IgG receptor and transporter

Product Properties

CAS	Ab175520

Associated Targets(Human)

FCGRT Tclin IgG receptor FcRn large subunit p51 (0 Activities)

Discover Target: FCGRT

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Specifications

Specification Sheet

References

1. Liu L, Garcia AM, Santoro H, Zhang Y, McDonnell K, Dumont J, Bitonti A. (2007) Amelioration of experimental autoimmune myasthenia gravis in rats by neonatal FcR blockade.. J Immunol, 178 (8): (5390-8). [PMID:17404325] [10.1021/op500134e]
2. Petkova SB, Akilesh S, Sproule TJ, Christianson GJ, Al Khabbaz H, Brown AC, Presta LG, Meng YG, Roopenian DC. (2006) Enhanced half-life of genetically engineered human IgG1 antibodies in a humanized FcRn mouse model: potential application in humorally mediated autoimmune disease.. Int Immunol, 18 (12): (1759-69). [PMID:17077181] [10.1021/op500134e]
3. Vaccaro C, Zhou J, Ober RJ, Ward ES. (2005) Engineering the Fc region of immunoglobulin G to modulate in vivo antibody levels.. Nat Biotechnol, 23 (10): (1283-8). [PMID:16186811] [http://pubmed.ncbi.nlm.nih.gov/16186811]
4. Roopenian DC, Akilesh S. (2007) FcRn: the neonatal Fc receptor comes of age.. Nat Rev Immunol, 7 (9): (715-25). [PMID:17703228] [10.1021/op500134e]

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