L-739,750 , CAS No.160141-08-2, Inhibitor of farnesyltransferase; CAAX box; beta

In stock

Item Number

L611407

Grouped product items
SKU	Size	Availability	Price	Qty
L611407-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,334.90
L611407-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,891.90

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Synonyms

L 739750

Specifications & Purity

Moligand™

Grade

Moligand™

Action Type

INHIBITOR

Mechanism of action

Inhibitor of farnesyltransferase; CAAX box; beta

Names and Identifiers

IUPAC Name	(2S)-2-[[(2S)-2-[(2S,3S)-2-[[(2R)-2-amino-3-sulfanylpropyl]amino]-3-methylpentoxy]-3-phenylpropanoyl]amino]-4-methylsulfonylbutanoic acid
INCHI	InChI=1S/C23H39N3O6S2/c1-4-16(2)20(25-13-18(24)15-33)14-32-21(12-17-8-6-5-7-9-17)22(27)26-19(23(28)29)10-11-34(3,30)31/h5-9,16,18-21,25,33H,4,10-15,24H2,1-3H3,(H,26,27)(H,28,29)/t16-,18+,19-,20+,21-/m0/s1
InChi Key	SIEXHGZWGJLLAC-OSTWSGHESA-N
Canonical SMILES	CC[C@@H]([C@H](NC[C@H](CS)N)CO[C@H](C(=O)N[C@H](C(=O)O)CCS(=O)(=O)C)Cc1ccccc1)C
Isomeric SMILES	CC[C@H](C)[C@@H](CO[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCS(=O)(=O)C)C(=O)O)NC[C@H](CS)N
PubChem CID	5287548

Chemical and Physical Properties

Molecular Weight	517.700 g/mol
XLogP3	-0.800
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	17
Exact Mass	517.228 Da
Monoisotopic Mass	517.228 Da
Topological Polar Surface Area	157.000 Å²
Heavy Atom Count	34
Formal Charge	0
Complexity	710.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

References

1. Kohl NE, Wilson FR, Mosser SD, Giuliani E, deSolms SJ, Conner MW, Anthony NJ, Holtz WJ, Gomez RP, Lee TJ et al.. (1994) Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice.. Proc Natl Acad Sci USA, 91 (19): (9141-5). [PMID:8090782] [10.1021/op500134e]
2. Downward J. (2003) Targeting RAS signalling pathways in cancer therapy.. Nat Rev Cancer, 3 (1): (11-22). [PMID:12509763] [10.1021/op500134e]

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Basic Description