L-741,742 hydrochloride - ≥98%(HPLC), high purity , CAS No.874882-93-6

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Item Number

L288128

Grouped product items
SKU	Size	Availability	Price
L288128-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$98.90
L288128-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$151.90
L288128-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$339.90
L288128-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$625.90
L288128-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$1,125.90

Highly selective D4antagonist

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Basic Description

Synonyms	C22H31N3O3.2HCl \| SR-01000597843 \| SR-01000597843-1 \| 79Y3N86U2E \| UNII-79Y3N86U2E \| AKOS024456331 \| L 741742 \| 8-[2-[4-(methoxyphenyl)-1-piperazin yl]ethyl]-8-azaspiro[4.5]decane-7,9-dione dihydrochloride \| L-741,742Hydrochloride \| 4-[5-(4-chlorophenyl)-
Specifications & Purity	≥98%(HPLC)
Biochemical and Physiological Mechanisms	A potent and highly selective D4dopamine receptor antagonist, with Kivalues of > 1700, 770 and 3.5 nM at cloned human D2, D3and D4receptors.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Product Description	Product Describtion: highly potent and selective D4 dopamine receptor antagonist.

Names and Identifiers

IUPAC Name	5-(4-chlorophenyl)-4-methyl-3-[1-(2-phenylethyl)piperidin-4-yl]-1,2-oxazole;hydrochloride
INCHI	InChI=1S/C23H25ClN2O.ClH/c1-17-22(25-27-23(17)20-7-9-21(24)10-8-20)19-12-15-26(16-13-19)14-11-18-5-3-2-4-6-18;/h2-10,19H,11-16H2,1H3;1H
InChi Key	HZRPUQURUAXOHB-UHFFFAOYSA-N
Canonical SMILES	CC1=C(ON=C1C2CCN(CC2)CCC3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl
Isomeric SMILES	CC1=C(ON=C1C2CCN(CC2)CCC3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl
PubChem CID	24744861
Molecular Weight	417.38

Chemical and Physical Properties

Solubility	Solvent:DMSO, Max Conc. mg/mL: 4.17, Max Conc. mM: 10
Molecular Weight	417.400 g/mol
XLogP3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	416.142 Da
Monoisotopic Mass	416.142 Da
Topological Polar Surface Area	29.300 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	440.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

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Basic Description