Lys-CoA, Inhibitor of E1A binding protein p300;Inhibitor of lysine acetyltransferase 2B, CAS No.rp174483, Inhibitor of E1A binding protein p300;Inhibitor of lysine acetyltransferase 2B

Features and benefits
    In stock
    Item Number
    rp174483
    Grouped product items
    SKUSizeAvailabilityPrice Qty
    rp174483-500μg
    500μg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $1,334.90
    rp174483-1mg
    1mg
    Available within 8-12 weeks(?)
    Production requires sourcing of materials. We appreciate your patience and understanding.
    $2,334.90

    Basic Description

    Product NameLys-CoA, Inhibitor of E1A binding protein p300;Inhibitor of lysine acetyltransferase 2B, CAS No.rp174483
    GradeMoligand™
    Specifications & PurityMoligand™
    Action TypeINHIBITOR
    Mechanism of actionInhibitor of E1A binding protein p300;Inhibitor of lysine acetyltransferase 2B

    Associated Targets(Human)

    EP300 Tchem Histone acetyltransferase p300 (9 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    KAT2B Tchem Histone acetyltransferase KAT2B (1 Activities)
    Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
    EP300 Tchem Histone acetyltransferase p300 (1259 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    KAT2B Tchem Histone acetyltransferase PCAF (884 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
    KAT5 Tchem Histone acetyltransferase KAT5 (85 Activities)
    Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID

    Mechanisms of Action

    Mechanism of ActionAction Typetarget IDTarget NameTarget TypeTarget OrganismBinding Site NameReferences

    Product Specifications

    CASrp174483

    Certificates(CoA,COO,BSE/TSE and Analysis Chart)

    C of A & Other Certificates(BSE/TSE, COO):
    Analytical Chart:

    Specifications

    Genetic information

    Reference
    • 1. Kinetics and inhibition of recombinant human cystathionine gamma-lyase. Toward the rational control of transsulfuration., The Journal of biological chemistry, Steegborn, C C and 7 more authors.
    • 2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences., Proceedings of the National Academy of Sciences of the United States of America, Strausberg, Robert L RL and 83 more authors.
    • 3. Genomic basis of cystathioninuria (MIM 219500) revealed by multiple mutations in cystathionine gamma-lyase (CTH)., Human genetics, Wang, Jian J and Hegele, Robert A RA.
    • 4. Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase., Biochemical and biophysical research communications, Lu, Y Y, O'Dowd, B F BF, Orrego, H H and Israel, Y Y.
    • 5. Single nucleotide polymorphism in CTH associated with variation in plasma homocysteine concentration., Clinical genetics, Wang, J J, Huff, A M AM, Spence, J D JD and Hegele, R A RA.
    • 6. Cystathionine gamma-lyase overexpression inhibits cell proliferation via a H2S-dependent modulation of ERK1/2 phosphorylation and p21Cip/WAK-1., The Journal of biological chemistry, Yang, Guangdong G, Cao, Kun K, Wu, Lingyun L and Wang, Rui R.
    • 7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)., Genome research, Gerhard, Daniela S DS and 115 more authors.
    • 8. Towards a proteome-scale map of the human protein-protein interaction network., Nature, Rual, Jean-François JF and 37 more authors.
    • 9. The DNA sequence and biological annotation of human chromosome 1., Nature, Gregory, S G SG and 178 more authors.
    • 10. Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., International journal of cancer, Moore, Lee E LE and 14 more authors. more

    References

    1. Lau OD, Kundu TK, Soccio RE, Ait-Si-Ali S, Khalil EM, Vassilev A, Wolffe AP, Nakatani Y, Roeder RG, Cole PA.  (2000)  HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF..  Mol Cell,  (3): (589-95).  [PMID:10882143] [10.1021/op500134e]
    2. Cole PA.  (2008)  Chemical probes for histone-modifying enzymes..  Nat Chem Biol,  (10): (590-7).  [PMID:18800048] [10.1021/op500134e]

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