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Miridesap - 97%, high purity , Serum amyloid P-component cross-linking agent, CAS No.224624-80-0, Serum amyloid P-component cross-linking agent

Moligand™

≥97%

CAS#: 224624-80-0
Molecular Weight: 340.37
PubChem CID: 125516

In stock

Item Number

M412829

Grouped product items
SKU	Size	Availability	Price
M412829-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$38.90
M412829-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$60.90
M412829-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$121.90
M412829-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$181.90
M412829-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$272.90

View related series

amyloid P component，serum Inhibitor (1)

Basic Description

Synonyms	(R)-1-[6-[(R)-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl]-pyrrolidine-2-carboxylic acid \| 4avt \| Spectrum_001388 \| N-(3-[(1-Benzylcycloheptyl)oxy]propyl)-N,N-dimethylamine # \| CPOHPC acid \| D11464 \| Rauzide \| Phenethylamine, N-(2-hydroxyethyl)-alpha-methyl
Specifications & Purity	Moligand™, ≥97%
Biochemical and Physiological Mechanisms	Miridesap (CPHPC, Ro63-8695, GSK2315698) is a ligand for serum amyloid P component (SAP) and intends to inhibit and dissociate SAP binding to amyloid fibrils and tangles. CPHPC (Miridesap; Ro 63-8695) is an orally active serum amyloid P (SAP) blocker that
Storage Temp	Store at -20°C,Argon charged
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	CROSS-LINKING AGENT, INHIBITOR
Mechanism of action	Serum amyloid P-component cross-linking agent
Product Description	Information Miridesap (CPHPC, Ro63-8695, GSK2315698) is a ligand for serum amyloid P component (SAP) and intends to inhibit and dissociate SAP binding to amyloid fibrils and tangles.

Associated Targets(Human)

APCS Tchem Serum amyloid P-component (1 Activities)

Discover Target: APCS

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

APCS Tchem Serum amyloid P-component (232 Activities)

Discover Target: APCS

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

IUPAC Name	(2R)-1-[6-[(2R)-2-carboxypyrrolidin-1-yl]-6-oxohexanoyl]pyrrolidine-2-carboxylic acid
INCHI	InChI=1S/C16H24N2O6/c19-13(17-9-3-5-11(17)15(21)22)7-1-2-8-14(20)18-10-4-6-12(18)16(23)24/h11-12H,1-10H2,(H,21,22)(H,23,24)/t11-,12-/m1/s1
InChi Key	HZLAWYIBLZNRFZ-VXGBXAGGSA-N
Canonical SMILES	C1CC(N(C1)C(=O)CCCCC(=O)N2CCCC2C(=O)O)C(=O)O
Isomeric SMILES	C1C[C@@H](N(C1)C(=O)CCCCC(=O)N2CCC[C@@H]2C(=O)O)C(=O)O
PubChem CID	125516
Molecular Weight	340.37

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot Number	Certificate Type	Date	Item
A2422071	Certificate of Analysis	Dec 19, 2023	M412829
A2422070	Certificate of Analysis	Dec 19, 2023	M412829
A2422072	Certificate of Analysis	Dec 19, 2023	M412829
A2422073	Certificate of Analysis	Dec 19, 2023	M412829
A2422074	Certificate of Analysis	Dec 19, 2023	M412829
A2422075	Certificate of Analysis	Dec 19, 2023	M412829
A2422076	Certificate of Analysis	Dec 19, 2023	M412829
A2422077	Certificate of Analysis	Dec 19, 2023	M412829
A2422078	Certificate of Analysis	Dec 19, 2023	M412829
A2422079	Certificate of Analysis	Dec 19, 2023	M412829

Chemical and Physical Properties

Molecular Weight	340.370 g/mol
XLogP3	0.000
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	7
Exact Mass	340.163 Da
Monoisotopic Mass	340.163 Da
Topological Polar Surface Area	115.000 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	475.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Safety and Hazards(GHS)

Pictogram(s)	GHS05
Signal	Danger
Hazard Statements	H314:Causes severe skin burns and eye damage H318:Causes serious eye damage
Precautionary Statements	P280:Wear protective gloves/protective clothing/eye protection/face protection. P321:Specific treatment (see ... on this label). P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P301+P330+P331:IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing. P363:Wash contaminated clothing before reuse. P264+P265:Wash hands [and …] thoroughly after handling. Do not touch eyes. P305+P354+P338:IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. P317:Get emergency medical help. P302+P361+P354:IF ON SKIN: Take off Immediately all contaminated clothing. Immediately rinse with water for several minutes. P316:Get emergency medical help immediately.

Specifications

Specification Sheet

References

1. Pepys MB, Herbert J, Hutchinson WL, Tennent GA, Lachmann HJ, Gallimore JR, Lovat LB, Bartfai T, Alanine A, Hertel C et al.. (2002) Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis.. Nature, 417 (6886): (254-9). [PMID:12015594] [10.1021/op500134e]
2. Wermuth CG. (2004) Selective optimization of side activities: another way for drug discovery.. J Med Chem, 47 (6): (1303-14). [PMID:14998318] [10.1021/op500134e]
3. Kolstoe SE, Ridha BH, Bellotti V, Wang N, Robinson CV, Crutch SJ, Keir G, Kukkastenvehmas R, Gallimore JR, Hutchinson WL et al.. (2009) Molecular dissection of Alzheimer's disease neuropathology by depletion of serum amyloid P component.. Proc Natl Acad Sci USA, 106 (18): (7619-23). [PMID:19372378] [10.1021/op500134e]
4. Gillmore JD, Tennent GA, Hutchinson WL, Gallimore JR, Lachmann HJ, Goodman HJ, Offer M, Millar DJ, Petrie A, Hawkins PN et al.. (2010) Sustained pharmacological depletion of serum amyloid P component in patients with systemic amyloidosis.. Br J Haematol, 148 (5): (760-7). [PMID:20064157] [10.1021/op500134e]
5. Bodin K, Ellmerich S, Kahan MC, Tennent GA, Loesch A, Gilbertson JA, Hutchinson WL, Mangione PP, Gallimore JR, Millar DJ et al.. (2010) Antibodies to human serum amyloid P component eliminate visceral amyloid deposits.. Nature, 468 (7320): (93-7). [PMID:20962779] [10.1021/op500134e]

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