| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| T105948-1g | 1g | 9 | $22.90 | |
| T105948-5g | 5g | 9 | $102.90 | |
| T105948-25g | 25g | 3 | $176.90 | |
| T105948-100g | 100g | 3 | $636.90 |
Competitive ubiquitin ligase APC/C inhibitor.
| Synonyms | CCG-268391 | methyl tosyl-L-argininate hydrochloride | T0330 | N2-[(4-Methylphenyl)sulfonyl]-L-arginine methyl ester hydrochloride | D92326 | N-a-Tosyl-L-arginine methyl ester HCl | (S)-Methyl 5-guanidino-2-(4-methylphenylsulfonamido)pentanoate hydrochlor |
|---|---|
| Specifications & Purity | ≥98% |
| Biochemical and Physiological Mechanisms | Nα-p-Tosyl-L-arginine methyl ester (TAME) binds to anaphase-promoting complex (APC) and prevents its activation by Cdc20 and Cdh1.Competitive ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C) inhibitor. Promotes Cdc20 autoubiquitination by eje |
| Storage Temp | Store at -20°C |
| Shipped In | Ice chest + Ice pads |
| Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
| Product Description | Substrate for trypsin, thrombin, plasmin,and other proteases. |
| Pubchem Sid | 488192192 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488192192 |
| IUPAC Name | methyl (2S)-5-(diaminomethylideneamino)-2-[(4-methylphenyl)sulfonylamino]pentanoate;hydrochloride |
| INCHI | InChI=1S/C14H22N4O4S.ClH/c1-10-5-7-11(8-6-10)23(20,21)18-12(13(19)22-2)4-3-9-17-14(15)16;/h5-8,12,18H,3-4,9H2,1-2H3,(H4,15,16,17);1H/t12-;/m0./s1 |
| InChi Key | JIQFFACVQXXHMY-YDALLXLXSA-N |
| Canonical SMILES | CC1=CC=C(C=C1)S(=O)(=O)NC(CCCN=C(N)N)C(=O)OC.Cl |
| Isomeric SMILES | CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CCCN=C(N)N)C(=O)OC.Cl |
| WGK Germany | 3 |
| PubChem CID | 2723792 |
| Molecular Weight | 378.87 |
| Beilstein | 3922357 |
| Reaxy-Rn | 10499395 |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 G1604030 | Certificate of Analysis | Mar 13, 2024 | T105948 |
| B2302757 | Certificate of Analysis | Oct 25, 2022 | T105948 |
| B2302718 | Certificate of Analysis | Oct 25, 2022 | T105948 |
| B2302767 | Certificate of Analysis | Oct 25, 2022 | T105948 |
| B23021134 | Certificate of Analysis | Oct 25, 2022 | T105948 |
| B2302934 | Certificate of Analysis | Oct 25, 2022 | T105948 |
| B2303570 | Certificate of Analysis | Oct 25, 2022 | T105948 |
| B2303563 | Certificate of Analysis | Oct 25, 2022 | T105948 |
| B2303571 | Certificate of Analysis | Oct 25, 2022 | T105948 |
| I2402439 | Certificate of Analysis | Oct 26, 2021 | T105948 |
| J2213139 | Certificate of Analysis | Oct 26, 2021 | T105948 |
| Specific Rotation[α] | -14 ° (C=4, H2O) |
|---|---|
| Melt Point(°C) | 146-149°C |
| Molecular Weight | 378.900 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 6 |
| Rotatable Bond Count | 9 |
| Exact Mass | 378.113 Da |
| Monoisotopic Mass | 378.113 Da |
| Topological Polar Surface Area | 145.000 Ų |
| Heavy Atom Count | 24 |
| Formal Charge | 0 |
| Complexity | 503.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
| WGK Germany | 3 |
|---|---|
| Reaxy-Rn | 10499395 |
| 1. Hanfei Ye, Wenwen Yu. (2024) Different influences of dietary fiber from various sources on the in vitro digestibility of casein as uncovered by the study of protein-dietary fiber interactions. FOOD RESEARCH INTERNATIONAL, 176 (113845). [PMID:38163735] [10.1016/j.foodres.2023.113845] |
| 1. Hanfei Ye, Wenwen Yu. (2024) Different influences of dietary fiber from various sources on the in vitro digestibility of casein as uncovered by the study of protein-dietary fiber interactions. FOOD RESEARCH INTERNATIONAL, 176 (113845). [PMID:38163735] [10.1016/j.foodres.2023.113845] |
