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Naltrindole hydrochloride - ≥99%, high purity , CAS No.111469-81-9
Basic Description Synonyms Naltrindole hydrochloride, solid | Naltrindole HCl | 4,8-Methanobenzofuro[2,3-a]pyrido[4,3-b]carbazole-1,8a(9H)-diol, 7-(cyclopropylmethyl)-5,6,7,8,14,14b-hexahydro-,?(4bS,8R,8aS,14bR)-,?hydrochloride (1:1) | CS-6914 | MLS002153164 | Naltrindole hydrochlo Specifications & Purity ≥99% Biochemical and Physiological Mechanisms Highly selective, non-peptide δ-opioid receptor antagonist that crosses the blood-brain barrier. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description
Naltrindole is a potent antagonist of the human δ-opioid receptor (Ki = 0.02-0.3 nM), with much lower affinities for κ- and µ-opioid receptors (Kis = 10-66 and 6-64 nM, respectively).1,2 Naltrindole is commonly used to investigate the role of the δ-opioid receptor in signaling responses to test compounds.
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (1S,2S,13R,21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazaheptacyclo[13.9.1.01,13.02,21.04,12.05,10.019,25]pentacosa-4(12),5,7,9,15,17,19(25)-heptaene-2,16-diol;hydrochloride INCHI InChI=1S/C26H26N2O3.ClH/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14;/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2;1H/t20-,24+,25+,26-;/m1./s1 InChi Key KNJKRQXCFJCQHC-IDRHMUJXSA-N Canonical SMILES C1CC1CN2CCC34C5C6=C(CC3(C2CC7=C4C(=C(C=C7)O)O5)O)C8=CC=CC=C8N6.Cl Isomeric SMILES C1CC1CN2CC[C@]34[C@@H]5C6=C(C[C@]3([C@H]2CC7=C4C(=C(C=C7)O)O5)O)C8=CC=CC=C8N6.Cl WGK Germany 3 Molecular Weight 450.96 Reaxy-Rn 26095522 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26095522&ln=
Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Sensitivity Moisture sensitive. Molecular Weight 451.000 g/mol XLogP3 Hydrogen Bond Donor Count 4 Hydrogen Bond Acceptor Count 4 Rotatable Bond Count 2 Exact Mass 450.171 Da Monoisotopic Mass 450.171 Da Topological Polar Surface Area 68.700 Ų Heavy Atom Count 32 Formal Charge 0 Complexity 774.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 4 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 2
Safety and Hazards(GHS) WGK Germany 3 Reaxy-Rn 26095522 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=26095522&ln= RIDADR NONHforallmodesoftransport
Specifications Purity(HPLC) 99-100（%） LC-MS for identification Conforms Proton NMR spectrum Conforms to Structure
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