| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| Ab170567-100μg | 100μg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $109.90 | |
| Ab170567-1mg | 1mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $519.90 | |
| Ab170567-10mg | 10mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $2,239.90 | |
| Ab170567-5mg | 5mg | Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding. | $1,399.90 |
Purity≥95% (SDS-PAGE&SEC-HPLC); Endotoxin Level<1.0 EU/mg; Human IgG1; CHO; ELISA, Flow Cytometry, Functional assay, Animal Model; Unconjugated
| Product Name | Ozanezumab (anti-RTN4), for ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) various applications, specific to RTN4, >95%, high purity, Human IgG1, Antibody of reticulon 4 |
|---|---|
| Synonyms | Foocen | Neurite outgrowth inhibitor | Neuroendocrine-specific protein | Neuroendocrine-specific protein C homolog | Nogo protein | NSP | Reticulon-5 | RTN-x |
| Specifications & Purity | Carrier Free, Recombinant, Low Endotoxin, Azide Free, Validated, ≥95%(SDS-PAGE&SEC-HPLC), See COA |
| Biochemical and Physiological Mechanisms | Developmental neurite growth regulatory factor with a role as a negative regulator of axon-axon adhesion and growth, and as a facilitator of neurite branching. Regulates neurite fasciculation, branching and extension in the developing nervous system. Invo |
| Host species | Human |
| Specificity | RTN4 |
| Application | ELISA,Functional Assay,Flow cytometry,Kinetics (BLI),Kinetics (SPR) |
| Grade | Azide Free, Carrier Free, Low Endotoxin, Recombinant, Validated |
| Action Type | INHIBITOR |
| Mechanism of action | Antibody of reticulon 4 |
| Product Description | Ozanezumab (anti-RTN4) is a recombinant monoclonal antibody to RTN4. Ozanezumab can be used in amyotrophic lateral sclerosis (ALS) and multiple sclerosis research. |
| Antibody Type | Primary antibody |
|---|---|
| Clonality | Recombinant |
| Isotype | Human IgG1 |
| Light Chain Type | kappa |
| SDS-PAGE | 150 kDa |
| Purification Method | Protein A purified |
| Purity | >95% |
| Source | CHO supernatant |
| Shape | Liquid |
| Concentration | See COA |
| Storage Temp | Store at -80°C,Avoid repeated freezing and thawing |
| Shipped In | Ice chest + Ice pads |
| Stability And Storage | Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle. |
| CAS | 1310680-64-8 |
Ozanezumab (anti-RTN4) (Ab170567) - ELISA
Immobilized Recombinant Human NOGO-A(586-785)/RTN4-His protein at 2.0 μg/mL can bind Ozanezumab (anti-RTN4) (Ab170567) with the EC50 of 13.32 ng/mL.
Ozanezumab (anti-RTN4) (Ab170567) - SEC
The purity of Ozanezumab (anti-RTN4) (Ab170567) is more than 95% verified by HPLC.
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
|---|
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
|---|
| 1. Chen MS, Huber AB, van der Haar ME, Frank M, Schnell L, Spillmann AA, Christ F, Schwab ME. (2000) Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1.. Nature, 403 (6768): (434-9). [PMID:10667796] [10.1021/op500134e] |
| 2. Jokic N, Gonzalez de Aguilar JL, Dimou L, Lin S, Fergani A, Ruegg MA, Schwab ME, Dupuis L, Loeffler JP. (2006) The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model.. EMBO Rep, 7 (11): (1162-7). [PMID:17039253] [10.1021/op500134e] |
| 3. Schmidt ER, Pasterkamp RJ, van den Berg LH. (2009) Axon guidance proteins: novel therapeutic targets for ALS?. Prog Neurobiol, 88 (4): (286-301). [PMID:19523502] [10.1021/op500134e] |
| 4. Schnell L, Schwab ME. (1990) Axonal regeneration in the rat spinal cord produced by an antibody against myelin-associated neurite growth inhibitors.. Nature, 343 (6255): (269-72). [PMID:2300171] [10.1021/op500134e] |
| 5. Caroni P, Schwab ME. (1988) Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter.. Neuron, 1 (1): (85-96). [PMID:3272156] [10.1021/op500134e] |
| 6. Yang J, Yu L, Bi AD, Zhao SY. (2000) Assignment of the human reticulon 4 gene (RTN4) to chromosome 2p14-->2p13 by radiation hybrid mapping.. Cytogenet Cell Genet, 88 (1-2): (101-2). [PMID:10773680] [10.1021/op500134e] |
| 7. GrandPré T, Nakamura F, Vartanian T, Strittmatter SM. (2000) Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein.. Nature, 403 (6768): (439-44). [PMID:10667797] [10.1021/op500134e] |
| 8. Crane EA, Heydenreuter W, Beck KR, Strajhar P, Vomacka J, Smiesko M, Mons E, Barth L, Neuburger M, Vedani A, Odermatt A, Sieber SA, Gademann K.. (2019) Profiling withanolide A for therapeutic targets in neurodegenerative diseases.. Bioorg Med Chem, 27 (12): (2508-2520). [PMID:30929949] [10.1016/j.bmc.2019.03.022] |
| 9. Nagase, T T and 9 more authors.. (1998) Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.. DNA research : an international journal for rapid publication of reports on genes and genomes, (31): [PMID:10048485] |
| 10. Prinjha, R R and 8 more authors.. (2000) Inhibitor of neurite outgrowth in humans.. Nature, (27): [PMID:10667780] |
| 11. Zhang, Q H QH and 20 more authors.. (2000) Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.. Genome research, [PMID:11042152] |
| 12. Tagami, S S, Eguchi, Y Y, Kinoshita, M M, Takeda, M M and Tsujimoto, Y Y.. (2000) A novel protein, RTN-XS, interacts with both Bcl-XL and Bcl-2 on endoplasmic reticulum and reduces their anti-apoptotic activity.. Oncogene, (23): [PMID:11126360] |
| 13. Fournier, A E AE, GrandPre, T T and Strittmatter, S M SM.. (2001) Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration.. Nature, (18): [PMID:11201742] |
| 14. Zhou, Z M ZM and 9 more authors.. (2002) Expression of a novel reticulon-like gene in human testis.. Reproduction (Cambridge, England), [PMID:11866689] |
| 15. Ng, Cherry Ee Lin CE and Tang, Bor Luen BL.. (2002) Nogos and the Nogo-66 receptor: factors inhibiting CNS neuron regeneration.. Journal of neuroscience research, (1): [PMID:11891768] |
| 16. Oertle, Thomas T, Huber, Chantal C, van der Putten, Herman H and Schwab, Martin E ME.. (2003) Genomic structure and functional characterisation of the promoters of human and mouse nogo/rtn4.. Journal of molecular biology, (10): [PMID:12488097] |
| 17. Qi, Bing B and 8 more authors.. (2003) Pro-apoptotic ASY/Nogo-B protein associates with ASYIP.. Journal of cellular physiology, [PMID:12811824] |
| 18. Acevedo, Lisette L and 8 more authors.. (2004) A new role for Nogo as a regulator of vascular remodeling.. Nature medicine, [PMID:15034570] |
| 19. He, Wanxia W and 5 more authors.. (2004) Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation.. Nature medicine, [PMID:15286784] |
| 20. Wan, Dafang D and 24 more authors.. (2004) Large-scale cDNA transfection screening for genes related to cancer development and progression.. Proceedings of the National Academy of Sciences of the United States of America, (2): [PMID:15498874] |
| 21. Miao, Robert Qing RQ and 8 more authors.. (2006) Identification of a receptor necessary for Nogo-B stimulated chemotaxis and morphogenesis of endothelial cells.. Proceedings of the National Academy of Sciences of the United States of America, (18): [PMID:16835300] |
| 22. Murayama, Kiyoko S KS and 5 more authors.. (2006) Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein.. The European journal of neuroscience, [PMID:16965550] |
| 23. He, Wanxia W and 6 more authors.. (2006) Mapping of interaction domains mediating binding between BACE1 and RTN/Nogo proteins.. Journal of molecular biology, (27): [PMID:16979658] |
| 24. Budel, Stéphane S and 18 more authors.. (2008) Genetic variants of Nogo-66 receptor with possible association to schizophrenia block myelin inhibition of axon growth.. The Journal of neuroscience : the official journal of the Society for Neuroscience, (3): [PMID:19052207] |
| 25. Hu, Junjie J and 7 more authors.. (2009) A class of dynamin-like GTPases involved in the generation of the tubular ER network.. Cell, (7): [PMID:19665976] |
| 26. Di Lorenzo, Annarita A, Manes, Thomas D TD, Davalos, Alberto A, Wright, Paulette L PL and Sessa, William C WC.. (2011) Endothelial reticulon-4B (Nogo-B) regulates ICAM-1-mediated leukocyte transmigration and acute inflammation.. Blood, (17): [PMID:21183689] |
| 27. Yamamoto, Yasunori Y, Yoshida, Asuka A, Miyazaki, Naoyuki N, Iwasaki, Kenji K and Sakisaka, Toshiaki T.. (2014) Arl6IP1 has the ability to shape the mammalian ER membrane in a reticulon-like fashion.. The Biochemical journal, (15): [PMID:24262037] |
| 28. Urade, Takeshi T, Yamamoto, Yasunori Y, Zhang, Xia X, Ku, Yonson Y and Sakisaka, Toshiaki T.. (2014) Identification and characterization of TMEM33 as a reticulon-binding protein.. The Kobe journal of medical sciences, (6): [PMID:25612671] |
| 29. Christodoulou, Andri A, Santarella-Mellwig, Rachel R, Santama, Niovi N and Mattaj, Iain W IW.. (2016) Transmembrane protein TMEM170A is a newly discovered regulator of ER and nuclear envelope morphogenesis in human cells.. Journal of cell science, (15): [PMID:26906412] |
| 30. Wang, Songyu S, Tukachinsky, Hanna H, Romano, Fabian B FB and Rapoport, Tom A TA.. (2016) Cooperation of the ER-shaping proteins atlastin, lunapark, and reticulons to generate a tubular membrane network.. eLife, (13): [PMID:27619977] |
| 31. Rämö, Olli O and 10 more authors.. (2016) NOGO-A/RTN4A and NOGO-B/RTN4B are simultaneously expressed in epithelial, fibroblast and neuronal cells and maintain ER morphology.. Scientific reports, (27): [PMID:27786289] |
| 32. Lee, Shin-Haw and 18 more authors.. (2020) REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects.. Nature communications, (19): [PMID:32075961] |
