Basic Description

Synonyms	Ocean Blue, SE \| PB succiniMidyl ester \| (2,5-dioxopyrrolidin-1-yl) 6,8-difluoro-7-hydroxy-2-oxochromene-3-carboxylate \| 3-Carboxy-6,8-difluoro-7-hydroxycoumarin succinimidyl ester \| 6,8-difluoro-7-hydroxy-2-oxo-2H-chromene-3-carboxylic acid succinimidyl
Specifications & Purity	Ex:404nm, Em:455nm, ≥98%
Storage Temp	Protected from light,Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Em:455nm, Ex:404nm
Product Description	Pacific blue succinimidyl ester is an N-hydroxysuccinimide ester derived from 6,8-difluoro-7-hydroxycoumarin-3-carboxylic acid (pacific blue). A fluorescent dye of excitation wavelength 403 nm and emission wavelength 455 nm. It has a role as a fluorochrome. It is a hydroxycoumarin, an organofluorine compound and a N-hydroxysuccinimide ester. It is functionally related to a pacific blue.

Names and Identifiers

IUPAC Name	(2,5-dioxopyrrolidin-1-yl) 6,8-difluoro-7-hydroxy-2-oxochromene-3-carboxylate
INCHI	InChI=1S/C14H7F2NO7/c15-7-4-5-3-6(13(21)23-12(5)10(16)11(7)20)14(22)24-17-8(18)1-2-9(17)19/h3-4,20H,1-2H2
InChi Key	NZYXABPVYJRICY-UHFFFAOYSA-N
Canonical SMILES	C1CC(=O)N(C1=O)OC(=O)C2=CC3=CC(=C(C(=C3OC2=O)F)O)F
Isomeric SMILES	C1CC(=O)N(C1=O)OC(=O)C2=CC3=CC(=C(C(=C3OC2=O)F)O)F
PubChem CID	56927770
Molecular Weight	339.20

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
B2526319	Certificate of Analysis	Dec 09, 2024	P638962
B2526321	Certificate of Analysis	Dec 09, 2024	P638962
B2526323	Certificate of Analysis	Dec 09, 2024	P638962
B2526326	Certificate of Analysis	Dec 09, 2024	P638962

Chemical and Physical Properties

Solubility	DMSO(Dimethylsulfoxide)
Sensitivity	Light sensitive; Moisture sensitive
Molecular Weight	339.200 g/mol
XLogP3	0.900
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	3
Exact Mass	339.019 Da
Monoisotopic Mass	339.019 Da
Topological Polar Surface Area	110.000 Å²
Heavy Atom Count	24
Formal Charge	0
Complexity	633.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Specifications

Purity(HPLC)	98-100（%）
Proton NMR spectrum	Conforms to Structure
LC-MS for identification	Conforms

Specification Sheet

Citations of This Product

How to Cite Aladdin Scientific Products?

1. Su Hongwei, Hu Hua, Li Zhenyu, Yan Guilong, Wang Li, Xiang Dong, Zhao Chunxia, Wu Yuanpeng, Chen Jingyu, Wang Ce. (2024) Pre-oxidized PAN Nanofibrous Membrane to Efficiently and Continuously Separate Large-Scale Viscous Oil-in-Water Emulsions Under Harsh Conditions with Ultra-Long-Term Oil-Fouling Recovery. Advanced Fiber Materials, 6 (3): (852-864). [PMID:] [10.1007/s42765-024-00383-y]
2. Yuan-Qiang Chen, Meng-Die Xue, Jia-Li Li, Da Huo, Hong-Ming Ding, Yuqiang Ma. (2024) Uncovering the Importance of Ligand Mobility on Cellular Uptake of Nanoparticles: Insights from Experimental, Computational, and Theoretical Investigations. ACS Nano, 18 (8): (6463-6476). [PMID:38346263] [10.1021/acsnano.3c11982]

References

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3. Marras SA, Kramer FR, Tyagi S. () Efficiencies of fluorescence resonance energy transfer and contact-mediated quenching in oligonucleotide probes.. Nucleic Acids Res, [PMID:12409481] [http://pubmed.ncbi.nlm.nih.gov/12409481]
4. Liu L, Guo Z, Tieu Q, Castle A, Castle D. () Role of secretory carrier membrane protein SCAMP2 in granule exocytosis.. Mol Biol Cell, [PMID:12475951] [http://pubmed.ncbi.nlm.nih.gov/12475951]
5. Roux MM, Pain A, Klimpel KR, Dhar AK. () The lipopolysaccharide and beta-1,3-glucan binding protein gene is upregulated in white spot virus-infected shrimp (Penaeus stylirostris).. J Virol, [PMID:12072514] [http://pubmed.ncbi.nlm.nih.gov/12072514]
6. Van Dover CL, German CR, Speer KG, Parson LM, Vrijenhoek RC. () Evolution and biogeography of deep-sea vent and seep invertebrates.. Science, [PMID:11847331] [http://pubmed.ncbi.nlm.nih.gov/11847331]
7. Sun WC, Gee KR, Haugland RP. () Synthesis of novel fluorinated coumarins: excellent UV-light excitable fluorescent dyes.. Bioorg Med Chem Lett, [PMID:9873685] [http://pubmed.ncbi.nlm.nih.gov/9873685]
8. Baart EB, Martini E, Van Opstal D. () Screening for aneuploidies of ten different chromosomes in two rounds of FISH: a short and reliable protocol.. Prenat Diagn, [PMID:15614916] [http://pubmed.ncbi.nlm.nih.gov/15614916]
9. Medler S. () Comparative trends in shortening velocity and force production in skeletal muscles.. Am J Physiol Regul Integr Comp Physiol, [PMID:12121850] [http://pubmed.ncbi.nlm.nih.gov/12121850]
10. Saavedra-Lozano J, Cao Y, Callison J, Sarode R, Sodora D, Edgar J, Hatfield J, Picker L, Peterson D, Ramilo O, Vitetta ES. () An anti-CD45RO immunotoxin kills HIV-latently infected cells from individuals on HAART with little effect on CD8 memory.. Proc Natl Acad Sci U S A, [PMID:14983037] [http://pubmed.ncbi.nlm.nih.gov/14983037]
11. Cox WG, Singer VL,. () Fluorescent DNA hybridization probe preparation using amine modification and reactive dye coupling.. Biotechniques, [PMID:14740493] [http://pubmed.ncbi.nlm.nih.gov/14740493]
12. Kohlsdorf T, James RS, Carvalho JE, Wilson RS, Dal Pai-Silva M, Navas CA. () Locomotor performance of closely related Tropidurus species: relationships with physiological parameters and ecological divergence.. J Exp Biol, [PMID:14978059] [http://pubmed.ncbi.nlm.nih.gov/14978059]
13. Lima RN, Kültz D. () Laser scanning cytometry and tissue microarray analysis of salinity effects on killifish chloride cells.. J Exp Biol, [PMID:15073205] [http://pubmed.ncbi.nlm.nih.gov/15073205]
14. Kalland ME, Oberprieler NG, Vang T, Taskén K, Torgersen KM,. () T cell-signaling network analysis reveals distinct differences between CD28 and CD2 costimulation responses in various subsets and in the MAPK pathway between resting and activated regulatory T cells.. J Immunol, [PMID:22013130] [http://pubmed.ncbi.nlm.nih.gov/22013130]
15. Clutter MR, Heffner GC, Krutzik PO, Sachen KL, Nolan GP,. () Tyramide signal amplification for analysis of kinase activity by intracellular flow cytometry.. Cytometry A, [PMID:20824632] [http://pubmed.ncbi.nlm.nih.gov/20824632]
16. Al Attar HA, Monkman AP,. () FRET and competing processes between conjugated polymer and dye substituted DNA strands: a comparative study of probe selection in DNA detection.. Biomacromolecules, [PMID:19334782] [http://pubmed.ncbi.nlm.nih.gov/19334782]
17. Kumari S,Wälchli S,Fallang LE,Yang W,Lund-Johansen F,Schumacher TN,Olweus J. () Alloreactive cytotoxic T cells provide means to decipher the immunopeptidome and reveal a plethora of tumor-associated self-epitopes.. , [PMID:24344295] [http://pubmed.ncbi.nlm.nih.gov/24344295]
18. Irish JM, Myklebust JH, Alizadeh AA, Houot R, Sharman JP, Czerwinski DK, Nolan GP, Levy R,. () B-cell signaling networks reveal a negative prognostic human lymphoma cell subset that emerges during tumor progression.. Proc Natl Acad Sci U S A, [PMID:20543139] [http://pubmed.ncbi.nlm.nih.gov/20543139]
19. Chiesl TN, Chu WK, Stockton AM, Amashukeli X, Grunthaner F, Mathies RA,. () Enhanced amine and amino acid analysis using Pacific Blue and the Mars Organic Analyzer microchip capillary electrophoresis system.. Anal Chem, [PMID:19245228] [http://pubmed.ncbi.nlm.nih.gov/19245228]
20. Thurber GM,Reiner T,Yang KS,Kohler RH,Weissleder R. () Effect of Small-Molecule Modification on Single-Cell Pharmacokinetics of PARP Inhibitors.. , [PMID:24552776] [http://pubmed.ncbi.nlm.nih.gov/24552776]
21. Krutzik PO, Crane JM, Clutter MR, Nolan GP,. () High-content single-cell drug screening with phosphospecific flow cytometry.. Nat Chem Biol, [PMID:18157122] [http://pubmed.ncbi.nlm.nih.gov/18157122]
22. Johnston IA, Fernández DA, Calvo J, Vieira VL, North AW, Abercromby M, Garland T. () Reduction in muscle fibre number during the adaptive radiation of notothenioid fishes: a phylogenetic perspective.. J Exp Biol, [PMID:12819266] [http://pubmed.ncbi.nlm.nih.gov/12819266]
23. Su Hongwei, Hu Hua, Li Zhenyu, Yan Guilong, Wang Li, Xiang Dong, Zhao Chunxia, Wu Yuanpeng, Chen Jingyu, Wang Ce. (2024) Pre-oxidized PAN Nanofibrous Membrane to Efficiently and Continuously Separate Large-Scale Viscous Oil-in-Water Emulsions Under Harsh Conditions with Ultra-Long-Term Oil-Fouling Recovery. Advanced Fiber Materials, 6 (3): (852-864). [PMID:] [10.1007/s42765-024-00383-y]
24. Yuan-Qiang Chen, Meng-Die Xue, Jia-Li Li, Da Huo, Hong-Ming Ding, Yuqiang Ma. (2024) Uncovering the Importance of Ligand Mobility on Cellular Uptake of Nanoparticles: Insights from Experimental, Computational, and Theoretical Investigations. ACS Nano, 18 (8): (6463-6476). [PMID:38346263] [10.1021/acsnano.3c11982]

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SKU	Size	Availability	Price	Qty
P638962-1mg	1mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$199.90
P638962-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$688.90

Pacific Blue™ Succinimidyl Ester , CAS No.P638962