Pazopanib HCl (GW786034 HCl) - ≥98%, high purity , Vascular endothelial growth factor receptor inhibitor, CAS No.635702-64-6, Vascular endothelial growth factor receptor inhibitor

In stock

Item Number

P129722

Grouped product items
SKU	Size	Availability	Price
P129722-25mg	25mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$58.90
P129722-100mg	100mg	2	$195.90
P129722-250mg	250mg	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$441.90
P129722-1g	1g	Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience!	$1,587.90

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Basic Description

Synonyms	GW786034 HCl \| 5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide;hydrochloride \| pazopanib HCl \| Pazopanib HCl (GW786034 HCl) \| 5-((4-((2,3-Dimethyl-2H-indazol-6-yl)methylamino)pyrimidin-2-yl)amino)-2-methylben
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Pazopanib Hydrochloride (GW786034, Votrient, Armala) is a novel, multitargeted inhibitor of VEGFR-1, VEGFR-2, VEGFR-3, PDGFR, FGFR, c-Kit and c-fms with IC50 values of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Action Type	INHIBITOR
Mechanism of action	Vascular endothelial growth factor receptor inhibitor
Product Description	Pazopanib (GW786034) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively. A multi-targeted inhibitor.

Names and Identifiers

Pubchem Sid	504766519
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504766519
IUPAC Name	5-[[4-[(2,3-dimethylindazol-6-yl)-methylamino]pyrimidin-2-yl]amino]-2-methylbenzenesulfonamide;hydrochloride
INCHI	InChI=1S/C21H23N7O2S.ClH/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16;/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25);1H
InChi Key	MQHIQUBXFFAOMK-UHFFFAOYSA-N
Canonical SMILES	CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl
Isomeric SMILES	CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N.Cl
PubChem CID	11525740
Molecular Weight	473.98

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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4 results found

Lot Number	Certificate Type	Date	Item
J2130492	Certificate of Analysis	Aug 02, 2023	P129722
J2130493	Certificate of Analysis	Aug 02, 2023	P129722
J2130491	Certificate of Analysis	Aug 02, 2023	P129722
F1510063	Certificate of Analysis	Jan 19, 2023	P129722

Chemical and Physical Properties

Solubility	Soluble in DMSO (17 mg/ml at 25 °C), water (<1 mg/ml at 25 °C), ethanol (<1 mg/ml at 25 °C), and 30% PEG400/0.5% Tween80/5% propylene glycol (30 mg/ml at 25 °C).
Sensitivity	Air Sensitive,Hygroscopic,Heat Sensitive
Molecular Weight	474.000 g/mol
XLogP3
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	5
Exact Mass	473.14 Da
Monoisotopic Mass	473.14 Da
Topological Polar Surface Area	127.000 Å²
Heavy Atom Count	32
Formal Charge	0
Complexity	717.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	2

Safety and Hazards(GHS)

Pictogram(s)	GHS08, GHS09
Signal	Danger
Hazard Statements	H351:Suspected of causing cancer H411:Toxic to aquatic life with long lasting effects H400:Very toxic to aquatic life H372:Causes damage to organs through prolonged or repeated exposure H360:May damage fertility or the unborn child H361:Suspected of damaging fertility or the unborn child
Precautionary Statements	P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell.

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Basic Description