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Proglumide sodium salt - ≥98%(HPLC), high purity , CAS No.99247-33-3
Non-selective CCK antagonist
Basic Description
| Synonyms | AKOS024456624 | Proglumide sodium | FT-0727740 | HMS2234D22 | sodium;4-benzamido-5-(dipropylamino)-5-oxopentanoate | sodium 4-benzamido-5-(dipropylamino)-5-oxopentanoate | Proglumide (sodium) | 4-BENZOYLAMINO-5-DIPROPYLAMINO-5-OXOPENTANOIC ACID SODIUM SAL |
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| Specifications & Purity | ≥98%(HPLC) |
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| Biochemical and Physiological Mechanisms | Non-selective cholecystokinin (CCK) antagonist. Inhibits CCK-stimulated amylase secretion and prevents CCK-induced 2-deoxyglucose uptake in mouse pancreatic acini. Blocks growth of HT29 colon carcinoma cells in response to gastrin 17 treatment. Orally act |
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| Storage Temp | Store at 2-8°C,Argon charged,Desiccated |
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| Shipped In | Wet ice |
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| Product Description | Application：
Proglumide sodium salt has been used to study the effects of proglumide on macronutrient selection in European sea bass Dicentrarchus labrax, L.
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| Pubchem Sid | 504769620 |
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| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504769620 |
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| IUPAC Name | sodium;4-benzamido-5-(dipropylamino)-5-oxopentanoate |
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| INCHI | InChI=1S/C18H26N2O4.Na/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14;/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22);/q;+1/p-1 |
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| InChi Key | UFMWGCINVOIJSO-UHFFFAOYSA-M |
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| Canonical SMILES | CCCN(CCC)C(=O)C(CCC(=O)[O-])NC(=O)C1=CC=CC=C1.[Na+] |
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| Isomeric SMILES | CCCN(CCC)C(=O)C(CCC(=O)[O-])NC(=O)C1=CC=CC=C1.[Na+] |
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| Alternate CAS | 6620-60-6 |
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| PubChem CID | 23677833 |
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| Molecular Weight | 356.39 |
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Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
| Solubility | Solvent:water, Max Conc. mg/mL: 35.64, Max Conc. mM: 100 |
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| Molecular Weight | 356.400 g/mol |
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| XLogP3 | |
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| Hydrogen Bond Donor Count | 1 |
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| Hydrogen Bond Acceptor Count | 4 |
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| Rotatable Bond Count | 10 |
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| Exact Mass | 356.171 Da |
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| Monoisotopic Mass | 356.171 Da |
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| Topological Polar Surface Area | 89.500 Ų |
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| Heavy Atom Count | 25 |
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| Formal Charge | 0 |
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| Complexity | 419.000 |
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| Isotope Atom Count | 0 |
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| Defined Atom Stereocenter Count | 0 |
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| Undefined Atom Stereocenter Count | 1 |
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| Defined Bond Stereocenter Count | 0 |
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| Undefined Bond Stereocenter Count | 0 |
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| The total count of all stereochemical bonds | 0 |
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| Covalently-Bonded Unit Count | 2 |
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Specifications
| NMR Spectrum 1H | Conforms to Structure |
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| Purity(HPLC area) | 98-100（%） |
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| Appearance(P287748) | White to off-white solid |
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