Pyridostatin pentahydrochloride - ≥95%(HPLC), high purity , CAS No.1781882-65-2

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Item Number

P287345

Grouped product items
SKU	Size	Availability	Price
P287345-5mg	5mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$103.90
P287345-10mg	10mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$136.90
P287345-25mg	25mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$308.90
P287345-50mg	50mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$574.90
P287345-100mg	100mg	Available within 8-12 weeks(?) Production requires sourcing of materials. We appreciate your patience and understanding.	$874.90

Stabilizes G-quadruplexes; induces DNA damage and cell cycle arrest

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Basic Description

Specifications & Purity	≥95%(HPLC)
Biochemical and Physiological Mechanisms	Binds and stabilizes G-quadruplexes, inducing DNA damage and cell cycle arrest (Kd= 490 nM); targets the proto-oncogene Src, reducing Src protein abundance and Src-dependent motility in human breast cancer cells. Also targets telomeric G-quadruplexes, ind
Storage Temp	Room temperature,Desiccated
Shipped In	Normal

Names and Identifiers

IUPAC Name	4-(2-aminoethoxy)-2-N,6-N-bis[4-(2-aminoethoxy)quinolin-2-yl]pyridine-2,6-dicarboxamide;pentahydrochloride
INCHI	InChI=1S/C31H32N8O5.5ClH/c32-9-12-42-19-15-24(30(40)38-28-17-26(43-13-10-33)20-5-1-3-7-22(20)36-28)35-25(16-19)31(41)39-29-18-27(44-14-11-34)21-6-2-4-8-23(21)37-29;;;;;/h1-8,15-18H,9-14,32-34H2,(H,36,38,40)(H,37,39,41);5*1H
InChi Key	SRIZPFGTXSQRFM-UHFFFAOYSA-N
Canonical SMILES	C1=CC=C2C(=C1)C(=CC(=N2)NC(=O)C3=CC(=CC(=N3)C(=O)NC4=NC5=CC=CC=C5C(=C4)OCCN)OCCN)OCCN.Cl.Cl.Cl.Cl.Cl
Isomeric SMILES	C1=CC=C2C(=C1)C(=CC(=N2)NC(=O)C3=CC(=CC(=N3)C(=O)NC4=NC5=CC=CC=C5C(=C4)OCCN)OCCN)OCCN.Cl.Cl.Cl.Cl.Cl
PubChem CID	78243739
Molecular Weight	778.94

Chemical and Physical Properties

Solubility	Solvent:water, Max Conc. mg/mL: 15.58, Max Conc. mM: 20
Molecular Weight	778.900 g/mol
XLogP3
Hydrogen Bond Donor Count	10
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	13
Exact Mass	778.13 Da
Monoisotopic Mass	776.133 Da
Topological Polar Surface Area	203.000 Å²
Heavy Atom Count	49
Formal Charge	0
Complexity	850.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	6

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Basic Description