| SKU | Size | Availability | Price | Qty |
|---|---|---|---|---|
| S293790-50mg | 50mg | 4 | $19.90 | |
| S293790-250mg | 250mg | 4 | $79.90 | |
| S293790-1g | 1g | 3 | $169.90 |
| Synonyms | AY 22989 | AY-22989 | CHEBI:9168 | EC 610-965-5 | HMS2089A21 | RAPA | (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-{(2S)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl |
|---|---|
| Specifications & Purity | Moligand™, ≥95%(HPLC) |
| Biochemical and Physiological Mechanisms | A macrocyclic triene antibiotic that binds to and inhibits the molecular target of rapamycin (mTOR). It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). Rapamycin is a potent immunosuppressant and has antica |
| Storage Temp | Store at -20°C,Argon charged |
| Shipped In | Ice chest + Ice pads |
| Grade | Moligand™ |
| Product Description |
Anti-fungal and immunosuppressant. Selectively inhibits the mammalian target of rapamycin (mTOR) and blocks the subsequent activation of p70 S6 kinase (IC50 = 50 pM). Specifically inhibits mTORC1, but mTORC2 that phosphorylates Akt at Ser473 appears to be insensitive to rapamycin. Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Pubchem Sid | 504763502 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504763502 |
| IUPAC Name | (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-dihydroxy-12-[(2R)-1-[(1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl]-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentone |
| INCHI | InChI=1S/C51H79NO13/c1-30-16-12-11-13-17-31(2)42(61-8)28-38-21-19-36(7)51(60,65-38)48(57)49(58)52-23-15-14-18-39(52)50(59)64-43(33(4)26-37-20-22-40(53)44(27-37)62-9)29-41(54)32(3)25-35(6)46(56)47(63-10)45(55)34(5)24-30/h11-13,16-17,25,30,32-34,36-40,42-44,46-47,53,56,60H,14-15,18-24,26-29H2,1-10H3/b13-11+,16-12+,31-17+,35-25+/t30-,32-,33-,34-,36-,37+,38+,39+,40-,42+,43+,44-,46-,47+,51-/m1/s1 |
| InChi Key | QFJCIRLUMZQUOT-HPLJOQBZSA-N |
| Canonical SMILES | CC1CCC2CC(C(=CC=CC=CC(CC(C(=O)C(C(C(=CC(C(=O)CC(OC(=O)C3CCCCN3C(=O)C(=O)C1(O2)O)C(C)CC4CCC(C(C4)OC)O)C)C)O)OC)C)C)C)OC |
| Isomeric SMILES | C[C@@H]1CC[C@H]2C[C@@H](/C(=C/C=C/C=C/[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C/[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)O)C)/C)O)OC)C)C)/C)OC |
| RTECS | VE6250000 |
| Molecular Weight | 914.19 |
| Reaxy-Rn | 5848501 |
Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 C2505451 | Certificate of Analysis | Mar 07, 2025 | S293790 |
| C2505452 | Certificate of Analysis | Mar 07, 2025 | S293790 |
| C2505455 | Certificate of Analysis | Mar 07, 2025 | S293790 |
| B2527150 | Certificate of Analysis | Feb 28, 2025 | S293790 |
| L2403373 | Certificate of Analysis | Nov 22, 2024 | S293790 |
| L2403374 | Certificate of Analysis | Nov 22, 2024 | S293790 |
| A2307041 | Certificate of Analysis | Oct 21, 2024 | S293790 |
| A2307034 | Certificate of Analysis | Oct 21, 2024 | S293790 |
| A2307025 | Certificate of Analysis | Oct 21, 2024 | S293790 |
| A2307033 | Certificate of Analysis | Oct 11, 2024 | S293790 |
| A2307038 | Certificate of Analysis | Oct 11, 2024 | S293790 |
| E2225238 | Certificate of Analysis | Feb 23, 2024 | S293790 |
| E2225235 | Certificate of Analysis | Feb 23, 2024 | S293790 |
| E2225234 | Certificate of Analysis | Feb 23, 2024 | S293790 |
| A2422188 | Certificate of Analysis | Nov 10, 2022 | S293790 |
| A2307032 | Certificate of Analysis | Nov 10, 2022 | S293790 |
| H2312240 | Certificate of Analysis | Nov 10, 2022 | S293790 |
| C2428063 | Certificate of Analysis | Nov 10, 2022 | S293790 |
| A2221042 | Certificate of Analysis | Apr 28, 2021 | S293790 |
| Solubility | Soluble in DMSO at 50mg/ml or methanol at 25mg/mlSoluble in alcohol, dimethyl sulfoxide and dimethyl formamide. Insoluble in water. |
|---|---|
| Sensitivity | Heat sensitive. |
| Specific Rotation[α] | -150° (C=0.2,MeOH) |
| Melt Point(°C) | 177 °C(dec.) |
| Molecular Weight | 914.200 g/mol |
| XLogP3 | 6.000 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 13 |
| Rotatable Bond Count | 6 |
| Exact Mass | 913.555 Da |
| Monoisotopic Mass | 913.555 Da |
| Topological Polar Surface Area | 195.000 Ų |
| Heavy Atom Count | 65 |
| Formal Charge | 0 |
| Complexity | 1760.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 15 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 4 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 4 |
| Covalently-Bonded Unit Count | 1 |
| Pictogram(s) | GHS08 |
|---|---|
| Signal | Danger |
| Hazard Statements | H351:Suspected of causing cancer H372:Causes damage to organs through prolonged or repeated exposure H361:Suspected of damaging fertility or the unborn child |
| Precautionary Statements | P280:Wear protective gloves/protective clothing/eye protection/face protection. P405:Store locked up. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P270:Do not eat, drink or smoke when using this product. P203:Obtain, read and follow all safety instructions before use. P318:if exposed or concerned, get medical advice. P319:Get medical help if you feel unwell. |
| RTECS | VE6250000 |
| Reaxy-Rn | 5848501 |
| Merck Index | 8114 |
| Purity(HPLC) | 95-100（%） |
|---|---|
| Nitrogen by Elemental Analysis | 1.2-1.7（%） |
| Specific Rotation [a]20/D(c=0.2 in MeOH) | -155--145（°） |
| Carbon by Elemental Analysis | 66.5-67.5（%） |
| Appearance（S293790) | White to Yellow Powder |
| Proton NMR spectrum | Conforms to Structure |
| Solubility in CHCL3,Colorless to Pale Yellow to Yellow,Clear,4.90-5.10 mg/ml | Pass |
Starting at $15.90
Starting at $44.90
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| 2. Xiaowei Wang, Wenjun Zhang, Sheng Zeng, Liudi Wang, Bin Wang. (2023) Collagenase Type I and Probucol-Loaded Nanoparticles Penetrate the Extracellular Matrix to Target Hepatic Stellate Cells for Hepatic Fibrosis Therapy. Acta Biomaterialia, [PMID:38141933] [10.1016/j.actbio.2023.12.027] |
| 3. Xiaolin Zhang, Zhen Dong, Yuanmiao Yang, Chaolong Liu, Jisheng Li, Wenli Sun, Yikang Zhu, Yang Shen, Zhi Wang, Muhan Lü, Hongjuan Cui. (2023) Morusinol Extracted from Morus alba Inhibits Cell Proliferation and Induces Autophagy via FOXO3a Nuclear Accumulation-Mediated Cholesterol Biosynthesis Obstruction in Colorectal Cancer. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, (19): [PMID:37870273] [10.1021/acs.jafc.3c01244] |
| 4. Kangjia Ding, Xueke Yu, Dongfang Wang, Xiaofeng Wang, Qian Li. (2023) Small diameter expanded polytetrafluoroethylene vascular graft with differentiated inner and outer biomacromolecules for collaborative endothelialization, anti-thrombogenicity and anti-inflammation. COLLOIDS AND SURFACES B-BIOINTERFACES, 229 (113449). [PMID:37506438] [10.1016/j.colsurfb.2023.113449] |
| 5. Minghui Cai, Haijuan Sun, Yujia Huang, Haixu Yao, Chen Zhao, Jiao Wang, Hui Zhu. (2023) Resveratrol Protects Rat Ovarian Luteinized Granulosa Cells from H2O2-Induced Dysfunction by Activating Autophagy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (13): (10914). [PMID:37446088] [10.3390/ijms241310914] |
| 6. Xiaoqian Jiang, Xinxin Xu, Hua Kuang, Liqiang Liu, Liguang Xu, Aihua Qu, Chuanlai Xu. (2023) A gold-based immunochromatographic strip for the specific detection of tacrolimus in whole blood. Journal of Materials Chemistry B, 11 (20): (4464-4474). [PMID:37159048] [10.1039/D3TB00569K] |
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| 8. Xueyao Yang, Xin Zhao, Yanfei Liu, Yue Liu, Libo Liu, Ziyu An, Haoran Xing, Jinfan Tian, Xiantao Song. (2023) Ginkgo biloba extract protects against diabetic cardiomyopathy by restoring autophagy via adenosine monophosphate-activated protein kinase/mammalian target of the rapamycin pathway modulation. PHYTOTHERAPY RESEARCH, 37 (4): (1377-1390). [PMID:36751963] [10.1002/ptr.7746] |
| 9. Han Chengzhi, Qian Xinyi, Ren Xiaorong, Zhang Shutian, Hu Li, Li Jingyao, Huang Yijun, Huang Renhui, Ooi Kokwin, Lin Hong, Xia Chunmei. (2022) Inhibition of cGAS in Paraventricular Nucleus Attenuates Hypertensive Heart Injury Via Regulating Microglial Autophagy. MOLECULAR NEUROBIOLOGY, 59 (11): (7006-7024). [PMID:36070120] [10.1007/s12035-022-02994-1] |
| 10. Pan-Pan Hong, Cang Li, Guo-Juan Niu, Xiao-Fan Zhao, Jin-Xing Wang. (2022) White spot syndrome virus directly activates mTORC1 signaling to facilitate its replication via polymeric immunoglobulin receptor-mediated infection in shrimp. PLoS Pathogens, 18 (9): (e1010808). [PMID:36067252] [10.1371/journal.ppat.1010808] |
| 11. Rui Wang, Jian Lu, Jiasheng Yin, Han Chen, Hongmei Liu, Fei Xu, Tongtong Zang, Rende Xu, Chenguang Li, Yizhe Wu, Qilin Wu, Xiang Fei, Meifang Zhu, Li Shen, Junbo Ge. (2023) A TEMPOL and rapamycin loaded nanofiber-covered stent favors endothelialization and mitigates neointimal hyperplasia and local inflammation. Bioactive Materials, 19 (666). [PMID:35600979] [10.1016/j.bioactmat.2022.04.033] |
| 12. Qiang Chen, Chunjing Guo, Xiudi Zhou, Yanguo Su, Huimin Guo, Min Cao, Jing Li, Yue Zhang, Weiyi Zhao, Xin Gao, Shuqi Mi, Daquan Chen. (2022) N-acetylneuraminic acid and chondroitin sulfate modified nanomicelles with ROS-sensitive H2S donor via targeting E-selectin receptor and CD44 receptor for the efficient therapy of atherosclerosis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 211 (259). [PMID:35513096] [10.1016/j.ijbiomac.2022.04.180] |
| 13. Yanzhen Han, Yan Zhou, Liyuan Zhou, Xiaoyan Jia, Xiangjun Yu, Xiaohong An, Zhe Shi. (2022) Blockade of chloride channel-3 enhances cisplatin sensitivity of cholangiocarcinoma cells though inhibiting autophagy. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 100 (7): [PMID:35413227] [10.1139/cjpp-2022-0058] |
| 14. Miaomiao Qi, Xiang Liu, Ying Zhou, Haoyu Wang, Ying Zhao, Jing Ren, Jin Xiang. (2021) Berberine Inhibits MDA-MB-231 Cells as an Agonist of G Protein-Coupled Estrogen Receptor 1. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (21): (11466). [PMID:34768896] [10.3390/ijms222111466] |
| 15. Sun Shouxiang, Cao Xiaojuan, Castro L. Filipe C., Monroig Óscar, Gao Jian. (2021) A network-based approach to identify protein kinases critical for regulating srebf1 in lipid deposition causing obesity. FUNCTIONAL & INTEGRATIVE GENOMICS, 21 (5): (557-570). [PMID:34327622] [10.1007/s10142-021-00798-5] |
| 16. Li Luo, Guangchao Zang, Boyan Liu, Xian Qin, Yuchan Zhang, Yidan Chen, Haijun Zhang, Wei Wu, Guixue Wang. (2021) Bioengineering CXCR4-overexpressing cell membrane functionalized ROS-responsive nanotherapeutics for targeting cerebral ischemia-reperfusion injury. Theranostics, 11 (16): ( 8043–8056). [PMID:34335979] [10.7150/thno.60785] |
| 17. Zhang Yin, Wang Qinge, Xu Yuping, Sun Jing, Ding Yanbo, Wang Li, Chen Bingfang, Sun Kewen, Chen Jianping. (2021) Mitomycin C Inhibits Esophageal Fibrosis by Regulating Cell Apoptosis and Autophagy via lncRNA-ATB and miR-200b. Frontiers in Molecular Biosciences, 8 [PMID:34079820] [10.3389/fmolb.2021.675757] |
| 18. Chao Gu, Junqing Yang, Ying Luo, Dongzhi Ran, Xiaodan Tan, Pu Xiang, Huizhi Fei, Yi Lu, Wenjia Guo, Yujun Tu, Xia Liu, Hong Wang. (2021) ZNRF2 attenuates focal cerebral ischemia/reperfusion injury in rats by inhibiting mTORC1-mediated autophagy. EXPERIMENTAL NEUROLOGY, 342 (113759). [PMID:33992580] [10.1016/j.expneurol.2021.113759] |
| 19. Yiqun Xia, Jundixia Chen, Yun Yu, Fengjiao Wu, Xin Shen, Chenyu Qiu, Tingting Zhang, Lin Hong, Peisen Zheng, Rongrong Shao, Chenxin Xu, Fang Wu, Wei Chen, Congying Xie, Ri Cui, Peng Zou. (2021) Compensatory combination of mTOR and TrxR inhibitors to cause oxidative stress and regression of tumors. Theranostics, 11 (9): ( 4335–4350). [PMID:33754064] [10.7150/thno.52077] |
| 20. He Bingnan, Wang Xia, Jin Xini, Xue Zimeng, Zhu Jianbo, Wang Caiyun, Jin Yuanxiang, Fu Zhengwei. (2020) β-Cypermethrin promotes the adipogenesis of 3T3-L1 cells via inducing autophagy and shaping an adipogenesis-friendly microenvironment. ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 52 (8): (821-831). [PMID:32637997] [10.1093/abbs/gmaa049] |
| 21. Yilin Zhang, Dongwei Liu, Zhangsuo Liu. (2020) The benzo[b]fluoranthene in the atmospheric fine particulate matter induces mouse glomerular podocytes injury via inhibition of autophagy. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 195 (110403). [PMID:32193019] [10.1016/j.ecoenv.2020.110403] |
| 22. Bingnan He, Xia Wang, Jianbo Zhu, Baida Kong, Lai Wei, Yuanxiang Jin, Zhengwei Fu. (2019) Autophagy protects murine macrophages from β-cypermethrin-induced mitochondrial dysfunction and cytotoxicity via the reduction of oxidation stress. ENVIRONMENTAL POLLUTION, 250 (416). [PMID:31026688] [10.1016/j.envpol.2019.04.044] |
| 23. Li Qiang, Yin Yating, Zheng Yuqing, Chen Feifei, Jin Peisheng. (2018) Inhibition of autophagy promoted high glucose/ROS-mediated apoptosis in ADSCs. Stem Cell Research & Therapy, 9 (1): (1-11). [PMID:30359319] [10.1186/s13287-018-1029-4] |
| 24. Yang Su, Jingxiao Lu, Pian Gong, Xianguo Chen, Chaozhao Liang, Jie Zhang. (2018) Rapamycin induces autophagy to alleviate acute kidney injury following cerebral ischemia and reperfusion via the mTORC1/ATG13/ULK1 signaling pathway. Molecular Medicine Reports, 18 (6): (5445-5454). [PMID:30365078] [10.3892/mmr.2018.9586] |
| 25. Ting Wang, Jinhui Hu, Hao Luo, Huiyang Li, Jiahong Zhou, Lin Zhou, Shaohua Wei. (2018) Photosensitizer and Autophagy Promoter Coloaded ROS-Responsive Dendrimer-Assembled Carrier for Synergistic Enhancement of Tumor Growth Suppression. Small, 14 (38): (1802337). [PMID:30152186] [10.1002/smll.201802337] |
| 26. Wang Meng, Huang Can, Su Yong, Yang Cui, Xia Quan, Xu Du-juan. (2017) Astragaloside II sensitizes human hepatocellular carcinoma cells to 5-fluorouracil via suppression of autophagy. JOURNAL OF PHARMACY AND PHARMACOLOGY, 69 (6): (743-752). [PMID:28266023] [10.1111/jphp.12706] |
| 27. Wei-Rong Yang, Yong Wang, Yi Wang, Jiao-Jiao Zhang, Jia-Hua Zhang, Cheng Lu, Xian-Zhong Wang. (2015) mTOR is involved in 17β-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1, and CCNE1. MOLECULAR REPRODUCTION AND DEVELOPMENT, 82 (4): (305-314). [PMID:25739982] [10.1002/mrd.22473] |
| 28. Yi-jing Yin, Xing-wang Wang, Wei-qi Lu, Zhao-yang Chen, Jia-yin Fu, Ke-feng Ren, Jian Ji. (2025) Adhesive polyelectrolyte coating on PLGA particles prolongs drug retention to vessel lesion. JOURNAL OF CONTROLLED RELEASE, 378 (949). [PMID:39733912] [10.1016/j.jconrel.2024.12.068] |
| 29. Kun MA, Mengnan LI, Yahui SONG, Xinjing MAO, Shaolan ZHANG, Yaping ZHANG, Yuning JIANG, Chuanyuan JI, Kunxu NIU, Hongrong LI, Yunlong HOU, Cong WEI. (2024) Bazi Bushen alleviates reproductive aging in aged male mice. Chinese Journal of Natural Medicines, 22 (416). [PMID:38796215] [10.1016/S1875-5364(24)60639-4] |
| 30. Jia Song, Jinyu Qiao, Mingxue Chen, Jiahui Li, Jixia Wang, Dayong Yu, Huachuan Zheng, Liying Shi. (2025) Chaetoglobosin A induces apoptosis in T-24 human bladder cancer cells through oxidative stress and MAPK/PI3K-AKT-mTOR pathway. PeerJ, 13 (e19085). [PMID:40183046] [10.7717/peerj.19085] |
| 31. Qi Wang, Jiaxin Dong, Mengxian Du, Xinna Liu, Shiqi Zhang, Di Zhang, Wanyun Qin, Xikun Xu, Xianghui Li, Ruidong Su, Leyi Qiu, Baoqiang Li, Huiping Yuan. (2024) Chitosan-Rapamycin Carbon Dots Alleviate Glaucomatous Retinal Injury by Inducing Autophagy to Promote M2 Microglial Polarization. International Journal of Nanomedicine, 19 (2265-2284). [PMID:38476273] [10.2147/IJN.S440025] |
| 32. Liu Xin, Li Jiale, Liu Shuyu, Long Yan, Kang Ching, Zhao Chen, Wei Ling, Huang Shaoqi, Luo Yi, Dai Bo, Zhu Xiangjia. (2024) Fabrication of a 3D bioprinting model for posterior capsule opacification using GelMA and PLMA hydrogel-coated resin. Regenerative Biomaterials, [PMID:38529352] [10.1093/rb/rbae020] |
| 33. Lin Hui, Lin Shuaijun, Shi Liuhong, Xu Guangsen, Lin Manjie, Li Supeng, Chen Jiale, Li Zhiquan, Nakazibwe Catherine, Xiao Yunbei, Li Xiaokun, Pan Xuebo, Wang Cong. (2024) FGFR1 governs iron homeostasis via regulating intracellular protein degradation pathways of IRP2 in prostate cancer cells. Communications Biology, 7 (1): (1-13). [PMID:39154074] [10.1038/s42003-024-06704-6] |
| 34. Wentao Zhou, Caini Yu, Tingting Meng, Qi Jiang, Fangying Yu, Hong Yuan. (2025) Glutaminase-responsive nano-carrier for precise rejuvenation of senescent cells by restoring autophagy in chronic kidney disease treatment. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 674 (125469). [PMID:40089039] [10.1016/j.ijpharm.2025.125469] |
| 35. Xin Wang, Feiyang Pu, Xuanye Yang, Xili Feng, Jiayou Zhang, Kai Duan, Xuanxuan Nian, Zhongren Ma, Xiao-Xia Ma, Xiao-Ming Yang. (2024) Immunosuppressants exert antiviral effects against influenza A(H1N1)pdm09 virus via inhibition on nucleic acid synthesis, mRNA splicing and protein stability. Virulence, [PMID:38170681] [10.1080/21505594.2023.2301242] |
| 36. Xiao-Ye Lu, Qian-Yi Lv, Qi-Long Li, Hong Zhang, Chu-Tao Chen, Hao-Mei Tian. (2024) Impact of Acupuncture on Ischemia/Reperfusion Injury: Unraveling the Role of miR-34c-5p and Autophagy Activation. BRAIN RESEARCH BULLETIN, (111031). [PMID:39002935] [10.1016/j.brainresbull.2024.111031] |
| 37. Wenxuan Liu, Runlin Gui, Yang Li, Man Li, Zhen Lei, Yanyan Jin, Yi Yu, Yujia Li, Lu Qian, Yuyan Xiong. (2024) Linarin Identified as a Bioactive Compound of Lycii Cortex Ameliorates Insulin Resistance and Inflammation Through the c-FOS/ARG2 Signaling Axis. PHYTOTHERAPY RESEARCH, [PMID:39523692] [10.1002/ptr.8370] |
| 38. Ni An, Guzailinuer Yasen, Ximu Li, Xianbao Shi, Yongjun Wang, Hongzhuo Liu. (2025) Nanoparticle Adjuvants Incorporating Haptens Drive Potent Immune Tolerance to Accelerate Hair Regrowth. ACS Applied Materials & Interfaces, [PMID:39818727] [10.1021/acsami.4c17068] |
| 39. Huang Yue, Li Jinli, Pei Shifeng, You Heng, Liu Huimin, Guo Yaqiong, Xu Rui, Li Na, Feng Yaoyu, Xiao Lihua. (2024) Optimization of a DiCre recombinase system with reduced leakage for conditional genome editing of Cryptosporidium. Parasites & Vectors, 17 (1): (1-10). [PMID:39169430] [10.1186/s13071-024-06431-1] |
| 40. Zheng Jia, Lingdi Niu, Junjie Guo, Jiaqing Wang, Hai Li, Runhang Liu, Ning Liu, Shuhe Zhang, Fang Wang, Junwei Ge. (2025) Pathogen-derived peptidoglycan skeleton enhances innate immune defense against Staphylococcus aureus via mTOR-HIF-1α-HK2-mediated trained immunity. MICROBIOLOGICAL RESEARCH, 296 (128160). [PMID:40174361] [10.1016/j.micres.2025.128160] |
| 41. Kai Yin, Zhijian Hu, Meiting Yuan, Weidong Chen, Xinping Bi, Guobing Cui, Zhibin Liang, Yi Zhen Deng. (2024) Polyamine oxidation enzymes regulate sexual mating/filamentation and pathogenicity in Sporisorium scitamineum. MOLECULAR PLANT PATHOLOGY, 25 (9): (e70003). [PMID:39235122] [10.1111/mpp.70003] |
| 42. Jindan Xiao, Liuming Xie, Bing Zheng, Wenjie Ma, Yi Chen, Jianhua Xie, Xiaobo Hu, Qiang Yu. (2024) Polygonatum cyrtonema saponin supplementation ameliorated DSS-induced intestinal barrier injury via targeting the PI3K/AKT/mTOR-mediated autophagy/microbiota axis. Food Bioscience, 61 (104727). [PMID:] [10.1016/j.fbio.2024.104727] |
| 43. Kun Hu, Shaojun Wu, Jiaxin Xu, Yongzhen Zhang, Yanan Zhang, Xinyuan Wu, Jie Miao, Yongxu Yao, Susu Zhu, Guangtong Chen, Jie Ren. (2024) Pongamol Alleviates Neuroinflammation and Promotes Autophagy in Alzheimer’s Disease by Regulating the Akt/mTOR Signaling Pathway. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:38841893] [10.1021/acs.jafc.4c00836] |
| 44. Minghui Cai, Qiuyuan Li, Yang Cao, Yujia Huang, Haixu Yao, Chen Zhao, Jiao Wang, Hui Zhu. (2024) Quercetin activates autophagy to protect rats ovarian granulosa cells from H2O2-induced aging and injury. EUROPEAN JOURNAL OF PHARMACOLOGY, 966 (176339). [PMID:38272342] [10.1016/j.ejphar.2024.176339] |
| 45. Jiaxin Dong, Qi Wang, Tingting Gu, Guanxiong Liu, Yuri V. Petrov, Vladimir E. Baulin, Aslan Yu Tsivadze, Dechang Jia, Yu Zhou, Huiping Yuan, Baoqiang Li. (2024) Rapamycin functionalized carbon Dots: Target-oriented synthesis and suppression of vascular cell senescence. JOURNAL OF COLLOID AND INTERFACE SCIENCE, [PMID:38266335] [10.1016/j.jcis.2024.01.032] |
| 46. Leping He, Xijun Guo, Wanrong Wang, Weifeng Xu, Xiaoli Feng, Yuanfeng Fu, Yuxi Tian, Zongmao He, Sulan Luo, Jiaolin Bao, Ren-Bo Ding. (2024) Repurposing Sertraline for the Treatment of Colorectal Cancer by Blocking Autophagic Flux and Inhibiting Tumor Proliferation. Advanced Therapeutics, (2400199). [PMID:] [10.1002/adtp.202400199] |
| 47. Zhanhao Zhou, Hongbing Lan, Hongyuan Tan, Yi Wang, Wei Chen, Samira Batur, Chuansheng Fu, Li Kong, Conglian Yang, Boning Niu, Yuanyuan Guo, Zhiping Zhang, Kai Huang. (2024) ROS-responsive biomimetic nanovesicles to plaque microenvironment in targeted therapy of atherosclerosis. Nano Today, 59 (102530). [PMID:] [10.1016/j.nantod.2024.102530] |
| 48. Xue Jiang, Yinli Jin, Yongnian Zeng, Peng Shi, Wei Li. (2024) Self-Implantable Core–Shell Microneedle Patch for Long-Acting Treatment of Keratitis via Programmed Drug Release. Small, (2310461). [PMID:38396201] [10.1002/smll.202310461] |
| 49. Abdelmoaty Ahmed Attia Ahmed, Chen Jing, Zhang Kun, Wu Changhui, Li Ye, Li Peng, Xu Jianhua. (2024) Senolytic effect of triterpenoid complex from Ganoderma lucidum on adriamycin-induced senescent human hepatocellular carcinoma cells model in vitro and in vivo. Frontiers in Pharmacology, 15 [PMID:39364046] [10.3389/fphar.2024.1422363] |
| 50. Hai Li, Lingdi Niu, Jiaqing Wang, Qingru Chang, Shuhe Zhang, Jiaqi Wang, Jiankai Zeng, Mingchun Gao, Junwei Ge. (2024) Strategy against super-resistant bacteria: Curdlan-induced trained immunity combined with multi-epitope subunit vaccine. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 280 (135663). [PMID:39284466] [10.1016/j.ijbiomac.2024.135663] |
| 51. Lin Liu, Yucen Yao, Yang Liu, Bingrong Hong, Ziqing Li, Xuejun Chen, Yaofeng Zhang, Hongbo Fu, Degong Yang, Chunrong Yang. (2024) Targeted H2S-Mediated Gas Therapy with pH-Sensitive Release Property for Myocardial Ischemia–Reperfusion Injury by Platelet Membrane. Biomaterials Research, 28 (0061). [PMID:39161346] [10.34133/bmr.0061] |
| 52. Xuke Yang, Jichao Yang, Mengyu Lyu, Yaqiong Li, Anqi Liu, Bang Shen. (2024) The α subunit of AMP-activated protein kinase is critical for the metabolic success and tachyzoite proliferation of Toxoplasma gondii. Microbial Biotechnology, 17 (4): (e14455). [PMID:38635138] [10.1111/1751-7915.14455] |
| 53. Wenzhe Xiao, Binjian Wang, Xuemei Wang, Guanghong Zhang, Yihao Zhao, Zezhen Zhang, Linhua Li, Chao Qu. (2024) Two-electron oxidized polyphenol chemistry-inspired superhydrophilic drug-carrying coatings for the construction of multifunctional nasolacrimal duct stents. Journal of Materials Chemistry B, 12 (11): (2877-2893). [PMID:38426303] [10.1039/D3TB02668J] |
| 1. Xie Xu, Nana Tao, Caihua Sun, Robert D. Hoffman, Dongling Shi, Yuyuan Ying, Shujie Dong, Jianli Gao. (2023) Ligustilide prevents thymic immune senescence by regulating Thymosin β15-dependent spatial distribution of thymic epithelial cells. PHYTOMEDICINE, (155216). [PMID:38061285] [10.1016/j.phymed.2023.155216] |
| 2. Xiaowei Wang, Wenjun Zhang, Sheng Zeng, Liudi Wang, Bin Wang. (2023) Collagenase Type I and Probucol-Loaded Nanoparticles Penetrate the Extracellular Matrix to Target Hepatic Stellate Cells for Hepatic Fibrosis Therapy. Acta Biomaterialia, [PMID:38141933] [10.1016/j.actbio.2023.12.027] |
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| 4. Kangjia Ding, Xueke Yu, Dongfang Wang, Xiaofeng Wang, Qian Li. (2023) Small diameter expanded polytetrafluoroethylene vascular graft with differentiated inner and outer biomacromolecules for collaborative endothelialization, anti-thrombogenicity and anti-inflammation. COLLOIDS AND SURFACES B-BIOINTERFACES, 229 (113449). [PMID:37506438] [10.1016/j.colsurfb.2023.113449] |
| 5. Minghui Cai, Haijuan Sun, Yujia Huang, Haixu Yao, Chen Zhao, Jiao Wang, Hui Zhu. (2023) Resveratrol Protects Rat Ovarian Luteinized Granulosa Cells from H2O2-Induced Dysfunction by Activating Autophagy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24 (13): (10914). [PMID:37446088] [10.3390/ijms241310914] |
| 6. Xiaoqian Jiang, Xinxin Xu, Hua Kuang, Liqiang Liu, Liguang Xu, Aihua Qu, Chuanlai Xu. (2023) A gold-based immunochromatographic strip for the specific detection of tacrolimus in whole blood. Journal of Materials Chemistry B, 11 (20): (4464-4474). [PMID:37159048] [10.1039/D3TB00569K] |
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| 8. Xueyao Yang, Xin Zhao, Yanfei Liu, Yue Liu, Libo Liu, Ziyu An, Haoran Xing, Jinfan Tian, Xiantao Song. (2023) Ginkgo biloba extract protects against diabetic cardiomyopathy by restoring autophagy via adenosine monophosphate-activated protein kinase/mammalian target of the rapamycin pathway modulation. PHYTOTHERAPY RESEARCH, 37 (4): (1377-1390). [PMID:36751963] [10.1002/ptr.7746] |
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| 10. Pan-Pan Hong, Cang Li, Guo-Juan Niu, Xiao-Fan Zhao, Jin-Xing Wang. (2022) White spot syndrome virus directly activates mTORC1 signaling to facilitate its replication via polymeric immunoglobulin receptor-mediated infection in shrimp. PLoS Pathogens, 18 (9): (e1010808). [PMID:36067252] [10.1371/journal.ppat.1010808] |
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| 12. Qiang Chen, Chunjing Guo, Xiudi Zhou, Yanguo Su, Huimin Guo, Min Cao, Jing Li, Yue Zhang, Weiyi Zhao, Xin Gao, Shuqi Mi, Daquan Chen. (2022) N-acetylneuraminic acid and chondroitin sulfate modified nanomicelles with ROS-sensitive H2S donor via targeting E-selectin receptor and CD44 receptor for the efficient therapy of atherosclerosis. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 211 (259). [PMID:35513096] [10.1016/j.ijbiomac.2022.04.180] |
| 13. Yanzhen Han, Yan Zhou, Liyuan Zhou, Xiaoyan Jia, Xiangjun Yu, Xiaohong An, Zhe Shi. (2022) Blockade of chloride channel-3 enhances cisplatin sensitivity of cholangiocarcinoma cells though inhibiting autophagy. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 100 (7): [PMID:35413227] [10.1139/cjpp-2022-0058] |
| 14. Miaomiao Qi, Xiang Liu, Ying Zhou, Haoyu Wang, Ying Zhao, Jing Ren, Jin Xiang. (2021) Berberine Inhibits MDA-MB-231 Cells as an Agonist of G Protein-Coupled Estrogen Receptor 1. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 22 (21): (11466). [PMID:34768896] [10.3390/ijms222111466] |
| 15. Sun Shouxiang, Cao Xiaojuan, Castro L. Filipe C., Monroig Óscar, Gao Jian. (2021) A network-based approach to identify protein kinases critical for regulating srebf1 in lipid deposition causing obesity. FUNCTIONAL & INTEGRATIVE GENOMICS, 21 (5): (557-570). [PMID:34327622] [10.1007/s10142-021-00798-5] |
| 16. Li Luo, Guangchao Zang, Boyan Liu, Xian Qin, Yuchan Zhang, Yidan Chen, Haijun Zhang, Wei Wu, Guixue Wang. (2021) Bioengineering CXCR4-overexpressing cell membrane functionalized ROS-responsive nanotherapeutics for targeting cerebral ischemia-reperfusion injury. Theranostics, 11 (16): ( 8043–8056). [PMID:34335979] [10.7150/thno.60785] |
| 17. Zhang Yin, Wang Qinge, Xu Yuping, Sun Jing, Ding Yanbo, Wang Li, Chen Bingfang, Sun Kewen, Chen Jianping. (2021) Mitomycin C Inhibits Esophageal Fibrosis by Regulating Cell Apoptosis and Autophagy via lncRNA-ATB and miR-200b. Frontiers in Molecular Biosciences, 8 [PMID:34079820] [10.3389/fmolb.2021.675757] |
| 18. Chao Gu, Junqing Yang, Ying Luo, Dongzhi Ran, Xiaodan Tan, Pu Xiang, Huizhi Fei, Yi Lu, Wenjia Guo, Yujun Tu, Xia Liu, Hong Wang. (2021) ZNRF2 attenuates focal cerebral ischemia/reperfusion injury in rats by inhibiting mTORC1-mediated autophagy. EXPERIMENTAL NEUROLOGY, 342 (113759). [PMID:33992580] [10.1016/j.expneurol.2021.113759] |
| 19. Yiqun Xia, Jundixia Chen, Yun Yu, Fengjiao Wu, Xin Shen, Chenyu Qiu, Tingting Zhang, Lin Hong, Peisen Zheng, Rongrong Shao, Chenxin Xu, Fang Wu, Wei Chen, Congying Xie, Ri Cui, Peng Zou. (2021) Compensatory combination of mTOR and TrxR inhibitors to cause oxidative stress and regression of tumors. Theranostics, 11 (9): ( 4335–4350). [PMID:33754064] [10.7150/thno.52077] |
| 20. He Bingnan, Wang Xia, Jin Xini, Xue Zimeng, Zhu Jianbo, Wang Caiyun, Jin Yuanxiang, Fu Zhengwei. (2020) β-Cypermethrin promotes the adipogenesis of 3T3-L1 cells via inducing autophagy and shaping an adipogenesis-friendly microenvironment. ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 52 (8): (821-831). [PMID:32637997] [10.1093/abbs/gmaa049] |
| 21. Yilin Zhang, Dongwei Liu, Zhangsuo Liu. (2020) The benzo[b]fluoranthene in the atmospheric fine particulate matter induces mouse glomerular podocytes injury via inhibition of autophagy. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 195 (110403). [PMID:32193019] [10.1016/j.ecoenv.2020.110403] |
| 22. Bingnan He, Xia Wang, Jianbo Zhu, Baida Kong, Lai Wei, Yuanxiang Jin, Zhengwei Fu. (2019) Autophagy protects murine macrophages from β-cypermethrin-induced mitochondrial dysfunction and cytotoxicity via the reduction of oxidation stress. ENVIRONMENTAL POLLUTION, 250 (416). [PMID:31026688] [10.1016/j.envpol.2019.04.044] |
| 23. Li Qiang, Yin Yating, Zheng Yuqing, Chen Feifei, Jin Peisheng. (2018) Inhibition of autophagy promoted high glucose/ROS-mediated apoptosis in ADSCs. Stem Cell Research & Therapy, 9 (1): (1-11). [PMID:30359319] [10.1186/s13287-018-1029-4] |
| 24. Yang Su, Jingxiao Lu, Pian Gong, Xianguo Chen, Chaozhao Liang, Jie Zhang. (2018) Rapamycin induces autophagy to alleviate acute kidney injury following cerebral ischemia and reperfusion via the mTORC1/ATG13/ULK1 signaling pathway. Molecular Medicine Reports, 18 (6): (5445-5454). [PMID:30365078] [10.3892/mmr.2018.9586] |
| 25. Ting Wang, Jinhui Hu, Hao Luo, Huiyang Li, Jiahong Zhou, Lin Zhou, Shaohua Wei. (2018) Photosensitizer and Autophagy Promoter Coloaded ROS-Responsive Dendrimer-Assembled Carrier for Synergistic Enhancement of Tumor Growth Suppression. Small, 14 (38): (1802337). [PMID:30152186] [10.1002/smll.201802337] |
| 26. Wang Meng, Huang Can, Su Yong, Yang Cui, Xia Quan, Xu Du-juan. (2017) Astragaloside II sensitizes human hepatocellular carcinoma cells to 5-fluorouracil via suppression of autophagy. JOURNAL OF PHARMACY AND PHARMACOLOGY, 69 (6): (743-752). [PMID:28266023] [10.1111/jphp.12706] |
| 27. Wei-Rong Yang, Yong Wang, Yi Wang, Jiao-Jiao Zhang, Jia-Hua Zhang, Cheng Lu, Xian-Zhong Wang. (2015) mTOR is involved in 17β-estradiol-induced, cultured immature boar Sertoli cell proliferation via regulating the expression of SKP2, CCND1, and CCNE1. MOLECULAR REPRODUCTION AND DEVELOPMENT, 82 (4): (305-314). [PMID:25739982] [10.1002/mrd.22473] |
| 28. Yi-jing Yin, Xing-wang Wang, Wei-qi Lu, Zhao-yang Chen, Jia-yin Fu, Ke-feng Ren, Jian Ji. (2025) Adhesive polyelectrolyte coating on PLGA particles prolongs drug retention to vessel lesion. JOURNAL OF CONTROLLED RELEASE, 378 (949). [PMID:39733912] [10.1016/j.jconrel.2024.12.068] |
| 29. Kun MA, Mengnan LI, Yahui SONG, Xinjing MAO, Shaolan ZHANG, Yaping ZHANG, Yuning JIANG, Chuanyuan JI, Kunxu NIU, Hongrong LI, Yunlong HOU, Cong WEI. (2024) Bazi Bushen alleviates reproductive aging in aged male mice. Chinese Journal of Natural Medicines, 22 (416). [PMID:38796215] [10.1016/S1875-5364(24)60639-4] |
| 30. Jia Song, Jinyu Qiao, Mingxue Chen, Jiahui Li, Jixia Wang, Dayong Yu, Huachuan Zheng, Liying Shi. (2025) Chaetoglobosin A induces apoptosis in T-24 human bladder cancer cells through oxidative stress and MAPK/PI3K-AKT-mTOR pathway. PeerJ, 13 (e19085). [PMID:40183046] [10.7717/peerj.19085] |
| 31. Qi Wang, Jiaxin Dong, Mengxian Du, Xinna Liu, Shiqi Zhang, Di Zhang, Wanyun Qin, Xikun Xu, Xianghui Li, Ruidong Su, Leyi Qiu, Baoqiang Li, Huiping Yuan. (2024) Chitosan-Rapamycin Carbon Dots Alleviate Glaucomatous Retinal Injury by Inducing Autophagy to Promote M2 Microglial Polarization. International Journal of Nanomedicine, 19 (2265-2284). [PMID:38476273] [10.2147/IJN.S440025] |
| 32. Liu Xin, Li Jiale, Liu Shuyu, Long Yan, Kang Ching, Zhao Chen, Wei Ling, Huang Shaoqi, Luo Yi, Dai Bo, Zhu Xiangjia. (2024) Fabrication of a 3D bioprinting model for posterior capsule opacification using GelMA and PLMA hydrogel-coated resin. Regenerative Biomaterials, [PMID:38529352] [10.1093/rb/rbae020] |
| 33. Lin Hui, Lin Shuaijun, Shi Liuhong, Xu Guangsen, Lin Manjie, Li Supeng, Chen Jiale, Li Zhiquan, Nakazibwe Catherine, Xiao Yunbei, Li Xiaokun, Pan Xuebo, Wang Cong. (2024) FGFR1 governs iron homeostasis via regulating intracellular protein degradation pathways of IRP2 in prostate cancer cells. Communications Biology, 7 (1): (1-13). [PMID:39154074] [10.1038/s42003-024-06704-6] |
| 34. Wentao Zhou, Caini Yu, Tingting Meng, Qi Jiang, Fangying Yu, Hong Yuan. (2025) Glutaminase-responsive nano-carrier for precise rejuvenation of senescent cells by restoring autophagy in chronic kidney disease treatment. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 674 (125469). [PMID:40089039] [10.1016/j.ijpharm.2025.125469] |
| 35. Xin Wang, Feiyang Pu, Xuanye Yang, Xili Feng, Jiayou Zhang, Kai Duan, Xuanxuan Nian, Zhongren Ma, Xiao-Xia Ma, Xiao-Ming Yang. (2024) Immunosuppressants exert antiviral effects against influenza A(H1N1)pdm09 virus via inhibition on nucleic acid synthesis, mRNA splicing and protein stability. Virulence, [PMID:38170681] [10.1080/21505594.2023.2301242] |
| 36. Xiao-Ye Lu, Qian-Yi Lv, Qi-Long Li, Hong Zhang, Chu-Tao Chen, Hao-Mei Tian. (2024) Impact of Acupuncture on Ischemia/Reperfusion Injury: Unraveling the Role of miR-34c-5p and Autophagy Activation. BRAIN RESEARCH BULLETIN, (111031). [PMID:39002935] [10.1016/j.brainresbull.2024.111031] |
| 37. Wenxuan Liu, Runlin Gui, Yang Li, Man Li, Zhen Lei, Yanyan Jin, Yi Yu, Yujia Li, Lu Qian, Yuyan Xiong. (2024) Linarin Identified as a Bioactive Compound of Lycii Cortex Ameliorates Insulin Resistance and Inflammation Through the c-FOS/ARG2 Signaling Axis. PHYTOTHERAPY RESEARCH, [PMID:39523692] [10.1002/ptr.8370] |
| 38. Ni An, Guzailinuer Yasen, Ximu Li, Xianbao Shi, Yongjun Wang, Hongzhuo Liu. (2025) Nanoparticle Adjuvants Incorporating Haptens Drive Potent Immune Tolerance to Accelerate Hair Regrowth. ACS Applied Materials & Interfaces, [PMID:39818727] [10.1021/acsami.4c17068] |
| 39. Huang Yue, Li Jinli, Pei Shifeng, You Heng, Liu Huimin, Guo Yaqiong, Xu Rui, Li Na, Feng Yaoyu, Xiao Lihua. (2024) Optimization of a DiCre recombinase system with reduced leakage for conditional genome editing of Cryptosporidium. Parasites & Vectors, 17 (1): (1-10). [PMID:39169430] [10.1186/s13071-024-06431-1] |
| 40. Zheng Jia, Lingdi Niu, Junjie Guo, Jiaqing Wang, Hai Li, Runhang Liu, Ning Liu, Shuhe Zhang, Fang Wang, Junwei Ge. (2025) Pathogen-derived peptidoglycan skeleton enhances innate immune defense against Staphylococcus aureus via mTOR-HIF-1α-HK2-mediated trained immunity. MICROBIOLOGICAL RESEARCH, 296 (128160). [PMID:40174361] [10.1016/j.micres.2025.128160] |
| 41. Kai Yin, Zhijian Hu, Meiting Yuan, Weidong Chen, Xinping Bi, Guobing Cui, Zhibin Liang, Yi Zhen Deng. (2024) Polyamine oxidation enzymes regulate sexual mating/filamentation and pathogenicity in Sporisorium scitamineum. MOLECULAR PLANT PATHOLOGY, 25 (9): (e70003). [PMID:39235122] [10.1111/mpp.70003] |
| 42. Jindan Xiao, Liuming Xie, Bing Zheng, Wenjie Ma, Yi Chen, Jianhua Xie, Xiaobo Hu, Qiang Yu. (2024) Polygonatum cyrtonema saponin supplementation ameliorated DSS-induced intestinal barrier injury via targeting the PI3K/AKT/mTOR-mediated autophagy/microbiota axis. Food Bioscience, 61 (104727). [PMID:] [10.1016/j.fbio.2024.104727] |
| 43. Kun Hu, Shaojun Wu, Jiaxin Xu, Yongzhen Zhang, Yanan Zhang, Xinyuan Wu, Jie Miao, Yongxu Yao, Susu Zhu, Guangtong Chen, Jie Ren. (2024) Pongamol Alleviates Neuroinflammation and Promotes Autophagy in Alzheimer’s Disease by Regulating the Akt/mTOR Signaling Pathway. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:38841893] [10.1021/acs.jafc.4c00836] |
| 44. Minghui Cai, Qiuyuan Li, Yang Cao, Yujia Huang, Haixu Yao, Chen Zhao, Jiao Wang, Hui Zhu. (2024) Quercetin activates autophagy to protect rats ovarian granulosa cells from H2O2-induced aging and injury. EUROPEAN JOURNAL OF PHARMACOLOGY, 966 (176339). [PMID:38272342] [10.1016/j.ejphar.2024.176339] |
| 45. Jiaxin Dong, Qi Wang, Tingting Gu, Guanxiong Liu, Yuri V. Petrov, Vladimir E. Baulin, Aslan Yu Tsivadze, Dechang Jia, Yu Zhou, Huiping Yuan, Baoqiang Li. (2024) Rapamycin functionalized carbon Dots: Target-oriented synthesis and suppression of vascular cell senescence. JOURNAL OF COLLOID AND INTERFACE SCIENCE, [PMID:38266335] [10.1016/j.jcis.2024.01.032] |
| 46. Leping He, Xijun Guo, Wanrong Wang, Weifeng Xu, Xiaoli Feng, Yuanfeng Fu, Yuxi Tian, Zongmao He, Sulan Luo, Jiaolin Bao, Ren-Bo Ding. (2024) Repurposing Sertraline for the Treatment of Colorectal Cancer by Blocking Autophagic Flux and Inhibiting Tumor Proliferation. Advanced Therapeutics, (2400199). [PMID:] [10.1002/adtp.202400199] |
| 47. Zhanhao Zhou, Hongbing Lan, Hongyuan Tan, Yi Wang, Wei Chen, Samira Batur, Chuansheng Fu, Li Kong, Conglian Yang, Boning Niu, Yuanyuan Guo, Zhiping Zhang, Kai Huang. (2024) ROS-responsive biomimetic nanovesicles to plaque microenvironment in targeted therapy of atherosclerosis. Nano Today, 59 (102530). [PMID:] [10.1016/j.nantod.2024.102530] |
| 48. Xue Jiang, Yinli Jin, Yongnian Zeng, Peng Shi, Wei Li. (2024) Self-Implantable Core–Shell Microneedle Patch for Long-Acting Treatment of Keratitis via Programmed Drug Release. Small, (2310461). [PMID:38396201] [10.1002/smll.202310461] |
| 49. Abdelmoaty Ahmed Attia Ahmed, Chen Jing, Zhang Kun, Wu Changhui, Li Ye, Li Peng, Xu Jianhua. (2024) Senolytic effect of triterpenoid complex from Ganoderma lucidum on adriamycin-induced senescent human hepatocellular carcinoma cells model in vitro and in vivo. Frontiers in Pharmacology, 15 [PMID:39364046] [10.3389/fphar.2024.1422363] |
| 50. Hai Li, Lingdi Niu, Jiaqing Wang, Qingru Chang, Shuhe Zhang, Jiaqi Wang, Jiankai Zeng, Mingchun Gao, Junwei Ge. (2024) Strategy against super-resistant bacteria: Curdlan-induced trained immunity combined with multi-epitope subunit vaccine. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 280 (135663). [PMID:39284466] [10.1016/j.ijbiomac.2024.135663] |
| 51. Lin Liu, Yucen Yao, Yang Liu, Bingrong Hong, Ziqing Li, Xuejun Chen, Yaofeng Zhang, Hongbo Fu, Degong Yang, Chunrong Yang. (2024) Targeted H2S-Mediated Gas Therapy with pH-Sensitive Release Property for Myocardial Ischemia–Reperfusion Injury by Platelet Membrane. Biomaterials Research, 28 (0061). [PMID:39161346] [10.34133/bmr.0061] |
| 52. Xuke Yang, Jichao Yang, Mengyu Lyu, Yaqiong Li, Anqi Liu, Bang Shen. (2024) The α subunit of AMP-activated protein kinase is critical for the metabolic success and tachyzoite proliferation of Toxoplasma gondii. Microbial Biotechnology, 17 (4): (e14455). [PMID:38635138] [10.1111/1751-7915.14455] |
| 53. Wenzhe Xiao, Binjian Wang, Xuemei Wang, Guanghong Zhang, Yihao Zhao, Zezhen Zhang, Linhua Li, Chao Qu. (2024) Two-electron oxidized polyphenol chemistry-inspired superhydrophilic drug-carrying coatings for the construction of multifunctional nasolacrimal duct stents. Journal of Materials Chemistry B, 12 (11): (2877-2893). [PMID:38426303] [10.1039/D3TB02668J] |
