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Notch
RO4929097 - ≥98%, high purity , Gamma-secretase inhibitor, CAS No.847925-91-1, Gamma-secretase inhibitor

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RO4929097 - ≥98%, high purity , Gamma-secretase inhibitor, CAS No.847925-91-1, Gamma-secretase inhibitor

Moligand™

≥98%

CAS#: 847925-91-1
Molecular Weight: 469.4
PubChem CID: 49867930
PubChem SID: 504770956

In stock

Item Number

R127403

Grouped product items
SKU	Size	Availability	Price
R127403-5mg	5mg	2	$107.90
R127403-10mg	10mg	1	$195.90
R127403-25mg	25mg	1	$441.90
R127403-50mg	50mg	1	$608.90

View related series

Neuronal Signaling (3320) Notch (41) presenilin 1 Inhibitor (7) Stem Cell/Wnt (1019) γ-secretase (48)

Basic Description

Synonyms	NCGC00263162-01 \| Propanediamide, N-((7S)-6,7-dihydro-6-oxo-5H-dibenz(b,d)azepin-7-yl)-2,2-dimethyl-N'-(2,2,3,3,3-pentafluoropropyl)- \| J-523360 \| KK8645V7LE \| 2,2-dimethyl-N-[(10S)-9-oxo-8-azatricyclo[9.4.0.02,7]pentadeca-1(15),2,4,6,11,13-hexaen-10-yl]-
Specifications & Purity	Moligand™, ≥98%
Biochemical and Physiological Mechanisms	RO4929097 is an orally bioavailable, small-molecule gamma secretase (GS) inhibitor with an IC50 of 4 nM. It binds to GS and blocks activation of Notch receptors, which may inhibit tumor cell proliferation. RO4929097 inhibits Notch process
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Grade	Moligand™
Action Type	INHIBITOR
Mechanism of action	Gamma-secretase inhibitor

Product Properties

ALogP	4.6

Associated Targets(Human)

PSEN1 Tchem Presenilin-1 (1 Activities)

Discover Target: PSEN1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

A549 (127892 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

APH1A Tbio Gamma-secretase (4915 Activities)

Discover Target: APH1A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504770956
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504770956
IUPAC Name	2,2-dimethyl-N-[(7S)-6-oxo-5,7-dihydrobenzo[d][1]benzazepin-7-yl]-N'-(2,2,3,3,3-pentafluoropropyl)propanediamide
INCHI	InChI=1S/C22H20F5N3O3/c1-20(2,18(32)28-11-21(23,24)22(25,26)27)19(33)30-16-14-9-4-3-7-12(14)13-8-5-6-10-15(13)29-17(16)31/h3-10,16H,11H2,1-2H3,(H,28,32)(H,29,31)(H,30,33)/t16-/m0/s1
InChi Key	OJPLJFIFUQPSJR-INIZCTEOSA-N
Canonical SMILES	CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3NC1=O
Isomeric SMILES	CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O
PubChem CID	49867930
Molecular Weight	469.4

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

4 results found

Lot Number	Certificate Type	Date	Item
I2224527	Certificate of Analysis	Jul 22, 2022	R127403
I2224529	Certificate of Analysis	Jul 22, 2022	R127403
I2224526	Certificate of Analysis	Jul 22, 2022	R127403
I2224528	Certificate of Analysis	Jul 22, 2022	R127403

Chemical and Physical Properties

Solubility	DMSO 94 mg/mL Water <1 mg/mL Ethanol 16 mg/mL
Molecular Weight	469.400 g/mol
XLogP3	4.600
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	5
Exact Mass	469.142 Da
Monoisotopic Mass	469.142 Da
Topological Polar Surface Area	87.300 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	771.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Specifications

Purity(HPLC)	98-100（%）
NMR spectrum	Conforms to Structure

Specification Sheet

References

1. Huynh C, Poliseno L, Segura MF, Medicherla R, Haimovic A, Menendez S, Shang S, Pavlick A, Shao Y, Darvishian F et al.. (2011) The novel gamma secretase inhibitor RO4929097 reduces the tumor initiating potential of melanoma.. PLoS ONE, 6 (9): (e25264). [PMID:21980408] [10.1021/op500134e]
2. Tolcher AW, Messersmith WA, Mikulski SM, Papadopoulos KP, Kwak EL, Gibbon DG, Patnaik A, Falchook GS, Dasari A, Shapiro GI et al.. (2012) Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors.. J Clin Oncol, 30 (19): (2348-53). [PMID:22529266] [10.1021/op500134e]
3. Strosberg JR, Yeatman T, Weber J, Coppola D, Schell MJ, Han G, Almhanna K, Kim R, Valone T, Jump H et al.. (2012) A phase II study of RO4929097 in metastatic colorectal cancer.. Eur J Cancer, 48 (7): (997-1003). [PMID:22445247] [10.1021/op500134e]

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