Sacituzumab govitecan (anti-TROP2) - Primary antibody, specific to TACSTD2, >90% (SDS-PAGE&SEC), high purity, Human IgG1, Antibody of tumor associated calcium signal transducer 2, Antibody of tumor associated calcium signal transducer 2
Sacituzumab govitecan (anti-TROP2) - Primary antibody, specific to TACSTD2, >90% (SDS-PAGE&SEC), high purity, Human IgG1, Antibody of tumor associated calcium signal transducer 2, Antibody of tumor associated calcium signal transducer 2
Sacituzumab govitecan (anti-TROP2) - Primary antibody, specific to TACSTD2, >90% (SDS-PAGE&SEC), high purity, Human IgG1, Antibody of tumor associated calcium signal transducer 2
Antibody of tumor associated calcium signal transducer 2
Product Description
Sacituzumab govitecan (anti-TROP2) is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. Sacituzumab govitecan (anti-TROP2) shows anticancer activity.
Product Properties
Isotype
Human IgG1
Light Chain Type
kappa
SDS-PAGE
145 kDa
Purification Method
Protein A purified
Purity
>90% (SDS-PAGE&SEC)
Shape
Liquid
Concentration
See COA
Storage Temp
Store at -80°C,Avoid repeated freezing and thawing
Shipped In
Ice chest + Ice pads
Stability And Storage
Store at -80℃ for 24 months. Upon delivery aliquot. Avoid freeze/thaw cycle.
CAS
1491917-83-9
Images
Sacituzumab govitecan (anti-TROP2) (Ab175650) - Flow Cytometry Flow Cytometry analysis of MCF7 cells labelling TROP2 (red) with Sacituzumab govitecan (anti-TROP2) (Ab175650) at 1.0 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.
Sacituzumab govitecan (anti-TROP2) (Ab175650) - SEC The purity of Sacituzumab govitecan (anti-TROP2) (Ab175650) is more than 95% verified by HPLC.
Sacituzumab govitecan (anti-TROP2) (Ab175650) - ELISA Immobilized Recombinant huTROP2 (ECD)-chis protein at 2.0 μg/mL can bind Sacituzumab govitecan (anti-TROP2) (Ab175650) with the EC₅₀ of 5.81 ng/mL.
Associated Targets(Human)
TACSTD2TclinTumor-associated calcium signal transducer 2 (0 Activities)
1.Stoyanova T, Goldstein AS, Cai H, Drake JM, Huang J, Witte ON. (2012) Regulated proteolysis of Trop2 drives epithelial hyperplasia and stem cell self-renewal via β-catenin signaling.. Genes Dev, 26 (20):(2271-85). [PMID:23070813][10.1021/op500134e]
2.Ocean AJ, Starodub AN, Bardia A, Vahdat LT, Isakoff SJ, Guarino M, Messersmith WA, Picozzi VJ, Mayer IA, Wegener WA et al.. (2017) Sacituzumab govitecan (IMMU-132), an anti-Trop-2-SN-38 antibody-drug conjugate for the treatment of diverse epithelial cancers: Safety and pharmacokinetics.. Cancer, 123 (19):(3843-3854). [PMID:28558150][10.1021/op500134e]
4.Stein R, Basu A, Goldenberg DM, Lloyd KO, Mattes MJ. (1994) Characterization of cluster 13: the epithelial/carcinoma antigen recognized by MAb RS7.. Int J Cancer Suppl, 8 (13):(98-102). [PMID:8194903][10.1021/op500134e]
5.Stein R, Basu A, Chen S, Shih LB, Goldenberg DM. (1993) Specificity and properties of MAb RS7-3G11 and the antigen defined by this pancarcinoma monoclonal antibody.. Int J Cancer, 55 (6):(938-46). [PMID:8253531][10.1021/op500134e]
Solution Calculators
Molarity Calculator
Determine the necessary mass, volume, or concentration for preparing a solution.
Dilution Calculator
Determine the dilution needed to prepare a stock solution.
