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SB 297006 - 10mM in DMSO, high purity , CAS No.58816-69-6
Potent, selective CCR3 antagonist
Basic Description Synonyms 58816-69-6 | SB 297006 | SB297006 | (S)-Ethyl 2-benzamido-3-(4-nitrophenyl)propanoate | SB-297006 | CHEMBL284954 | ethyl (S)-2-benzamido-3-(4-nitrophenyl)propanoate | N-benzoyl-4-nitro-L-phenylalanine, ethyl ester | Ethyl (2S)-2-benzamido-3-(4-nitrophenyl)propanoate | N-Be Specifications & Purity 10mM in DMSO Biochemical and Physiological Mechanisms Highly potent, selective CCR3 antagonist (IC 50 = 2.5 μM). Displays 250-fold selectivity for CCR3 vs . CXCR1, CXCR2, CCR1 and CCR7 receptors. Potent inhibitor of Ca 2+ mobilization induced by eotaxin, eotaxin-2 and MCP-4 in human eosinophils (IC 50 values Storage Temp Store at -80°C Shipped In Ice chest + Ice pads Product Description
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name ethyl (2S)-2-benzamido-3-(4-nitrophenyl)propanoate INCHI InChI=1S/C18H18N2O5/c1-2-25-18(22)16(19-17(21)14-6-4-3-5-7-14)12-13-8-10-15(11-9-13)20(23)24/h3-11,16H,2,12H2,1H3,(H,19,21)/t16-/m0/s1 InChi Key BEZXGSZPWXRHIN-INIZCTEOSA-N Canonical SMILES CCOC(=O)C(CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC=CC=C2 Isomeric SMILES CCOC(=O)[C@H](CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC=CC=C2 PubChem CID 9840971 Molecular Weight 342.35
Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Sensitivity Heat Sensitive Specific Rotation[α] -86° (C=1,EtOH) Melt Point(°C) 121 °C Molecular Weight 342.300 g/mol XLogP3 3.300 Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 5 Rotatable Bond Count 7 Exact Mass 342.122 Da Monoisotopic Mass 342.122 Da Topological Polar Surface Area 101.000 Ų Heavy Atom Count 25 Formal Charge 0 Complexity 463.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 1 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
Safety and Hazards(GHS) Pictogram(s) GHS09 , GHS07 Signal Warning Hazard Statements H302: Harmful if swallowed
H400: Very toxic to aquatic life
Precautionary Statements P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
P264: Wash hands [and …] thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P391: Collect spillage.
P330: Rinse mouth.
P301+P317: IF SWALLOWED: Get medical help.
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