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Taltirelin - 98%, high purity , Thyrotropin-releasing hormone receptor agonist, CAS No.103300-74-9, Thyrotropin-releasing hormone receptor agonist
Synthetic thyrotropin-releasing hormone analog
Basic Description
| Synonyms | TALTIRELIN [MI] | CHEBI:135653 | CS-0010133 | GTPL2143 | Tox21_112682 | (S)-N-((S)-1-((S)-2-carbamoylpyrrolidin-1-yl)-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl)-1-methyl-2,6-dioxohexahydropyrimidine-4-carboxamide | Q7680336 | N-{[(4S)-1-methyl-2,6-dioxohexahy |
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| Specifications & Purity | Moligand™, ≥98% |
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| Biochemical and Physiological Mechanisms | Synthetic thyrotropin-releasing hormone (TRH) analog. Displays ~ 30 - 100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Antinociceptive and neuroprotective. |
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| Storage Temp | Store at -20°C |
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| Shipped In | Ice chest + Ice pads |
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| Grade | Moligand™ |
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| Action Type | AGONIST |
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| Mechanism of action | Thyrotropin-releasing hormone receptor agonist |
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Associated Targets(Human)
Associated Targets(non-human)
Mechanisms of Action
| Mechanism of Action | Action Type | target ID | Target Name | Target Type | Target Organism | Binding Site Name | References |
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Names and Identifiers
| Pubchem Sid | 488187512 |
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| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488187512 |
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| IUPAC Name | (4S)-N-[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-yl]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-1-methyl-2,6-dioxo-1,3-diazinane-4-carboxamide |
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| INCHI | InChI=1S/C17H23N7O5/c1-23-13(25)6-10(22-17(23)29)15(27)21-11(5-9-7-19-8-20-9)16(28)24-4-2-3-12(24)14(18)26/h7-8,10-12H,2-6H2,1H3,(H2,18,26)(H,19,20)(H,21,27)(H,22,29)/t10-,11-,12-/m0/s1 |
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| InChi Key | LQZAIAZUDWIVPM-SRVKXCTJSA-N |
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| Canonical SMILES | CN1C(=O)CC(NC1=O)C(=O)NC(CC2=CN=CN2)C(=O)N3CCCC3C(=O)N |
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| Isomeric SMILES | CN1C(=O)C[C@H](NC1=O)C(=O)N[C@@H](CC2=CN=CN2)C(=O)N3CCC[C@H]3C(=O)N |
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| PubChem CID | 114750 |
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| Molecular Weight | 405.41 |
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Certificates（CoA,COO,BSE/TSE and Analysis Chart)
Chemical and Physical Properties
| Solubility | Solvent:water, Max Conc. mg/mL: 20.27, Max Conc. mM: 50 |
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| Molecular Weight | 405.400 g/mol |
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| XLogP3 | -3.000 |
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| Hydrogen Bond Donor Count | 4 |
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| Hydrogen Bond Acceptor Count | 6 |
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| Rotatable Bond Count | 6 |
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| Exact Mass | 405.176 Da |
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| Monoisotopic Mass | 405.176 Da |
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| Topological Polar Surface Area | 171.000 Ų |
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| Heavy Atom Count | 29 |
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| Formal Charge | 0 |
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| Complexity | 714.000 |
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| Isotope Atom Count | 0 |
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| Defined Atom Stereocenter Count | 3 |
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| Undefined Atom Stereocenter Count | 0 |
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| Defined Bond Stereocenter Count | 0 |
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| Undefined Bond Stereocenter Count | 0 |
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| The total count of all stereochemical bonds | 0 |
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| Covalently-Bonded Unit Count | 1 |
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Specifications
| Appearance(T288583) | White to off-white powder or solid |
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| Purity(HPLC area) | 98-100（%） |
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| LC-MS for identification | Conforms |
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| NMR Spectrum 1H | Conforms to Structure |
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