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VTX-27 - 98%, high purity , CAS No.1321924-70-2
Basic Description Specifications & Purity ≥98% Biochemical and Physiological Mechanisms VTX-27 (Compound 27) is a potent and selective inhibitor of protein kinase C θ (PKC θ) with Ki of 0.08 nM and 16 nM for PKC θ and PKC δ, respectively. Storage Temp Store at -20°C Shipped In Ice chest + Ice pads Product Description Information
VTX-27 VTX-27 (Compound 27) is a potent and selective inhibitor of protein kinase C θ (PKC θ) with Ki of 0.08 nM and 16 nM for PKC θ and PKC δ, respectively.
Targets
PKCθ (Cell-free assay); PKCδ (Cell-free assay) 0.08 nM(Ki); 16 nM(Ki)
Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Mechanism of Action Action Type target ID Target Name Target Type Target Organism Binding Site Name References
Names and Identifiers IUPAC Name (2R)-2-[(2S)-4-[3-chloro-5-fluoro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-ol INCHI InChI=1S/C20H24ClFN6O/c1-11(2)20(3,29)15-10-28(8-7-23-15)19-13(21)9-14(22)17(25-19)16-12-5-4-6-24-18(12)27-26-16/h4-6,9,11,15,23,29H,7-8,10H2,1-3H3,(H,24,26,27)/t15-,20+/m0/s1 InChi Key HXWARSZQGAFXJM-MGPUTAFESA-N Canonical SMILES CC(C)C(C)(C1CN(CCN1)C2=C(C=C(C(=N2)C3=C4C=CC=NC4=NN3)F)Cl)O Isomeric SMILES CC(C)[C@](C)([C@@H]1CN(CCN1)C2=C(C=C(C(=N2)C3=C4C=CC=NC4=NN3)F)Cl)O PubChem CID 53354074 Molecular Weight 418.9
Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 84 mg/mL (200.52 mM); Ethanol: 5 mg/mL (11.93 mM); Water: Insoluble; Molecular Weight 418.900 g/mol XLogP3 2.900 Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 7 Rotatable Bond Count 4 Exact Mass 418.168 Da Monoisotopic Mass 418.168 Da Topological Polar Surface Area 90.000 Ų Heavy Atom Count 29 Formal Charge 0 Complexity 573.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 2 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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