Y-27632 - 98%, high purity , CAS No.146986-50-7, Inhibitor of protein kinase C epsilon;Inhibitor of protein kinase N2;Inhibitor of Rho associated coiled-coil containing protein kinase 1;Inhibitor of Rho associated coiled-coil containing protein kinase 2

In stock
Item Number
Y125330
Grouped product items
SKUSizeAvailabilityPrice Qty
Y125330-5mg
5mg
1
$37.90
Y125330-10mg
10mg
2
$52.90
Y125330-25mg
25mg
2
$89.90
Y125330-50mg
50mg
1
$169.90
Y125330-100mg
100mg
1
$279.90

Basic Description

SynonymsBDBM86729 | Bio2_000937 | NCGC00092276-06 | HY-10071 | Y27632 | y-27632 | 4-[(1R)-1-aminoethyl]-N-(4-pyridyl)cyclohexanecarboxamide | HMS1792N15 | HMS3403N15 | trans-4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexanecarboxamide | CCG-204428 | NCGC00092276-10
Specifications & PurityMoligand™, ≥98%
Biochemical and Physiological MechanismsY-27632 is ROCK inhibitor, as a novel bronchodilator. Y-27632 is available with IC50 of 3.3±0.25 μM and 2.8±0.2 μM in human and rabbit tissues, respectively.
Storage TempProtected from light,Store at -20°C,Argon charged
Shipped InIce chest + Ice pads
GradeMoligand™
Action TypeINHIBITOR
Mechanism of actionInhibitor of protein kinase C epsilon;Inhibitor of protein kinase N2;Inhibitor of Rho associated coiled-coil containing protein kinase 1;Inhibitor of Rho associated coiled-coil containing protein kinase 2

Associated Targets(Human)

ROCK2 Tclin Rho-associated protein kinase 2 (0 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
ROCK1 Tclin Rho-associated protein kinase 1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PKN2 Tchem Serine/threonine-protein kinase N2 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PRKCE Tchem Protein kinase C epsilon type (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)

Names and Identifiers

Pubchem Sid504758873
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/504758873
IUPAC Name 4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide
INCHI InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11?,12?/m1/s1
InChi Key IYOZTVGMEWJPKR-VOMCLLRMSA-N
Canonical SMILES CC(C1CCC(CC1)C(=O)NC2=CC=NC=C2)N
Isomeric SMILES C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N
PubChem CID 448042
Molecular Weight 247.34

Certificates(CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

10 results found

Lot NumberCertificate TypeDateItem
J2416821Certificate of AnalysisSep 27, 2024 Y125330
J2416822Certificate of AnalysisSep 27, 2024 Y125330
J2416823Certificate of AnalysisSep 27, 2024 Y125330
J2218767Certificate of AnalysisAug 15, 2024 Y125330
J2218780Certificate of AnalysisAug 15, 2024 Y125330
J2218782Certificate of AnalysisAug 15, 2024 Y125330
J2218783Certificate of AnalysisAug 15, 2024 Y125330
I2423663Certificate of AnalysisAug 15, 2024 Y125330
J2218757Certificate of AnalysisAug 14, 2024 Y125330
E2415061Certificate of AnalysisAug 10, 2022 Y125330

Chemical and Physical Properties

Solubility49 mg/mL(198.11 mM) in DMSO;Insoluble in Water;49 mg/mL (198.11 mM) in Ethanol
Sensitivitylight sensitive
Molecular Weight247.340 g/mol
XLogP30.900
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass247.168 Da
Monoisotopic Mass247.168 Da
Topological Polar Surface Area68.000 Ų
Heavy Atom Count18
Formal Charge0
Complexity268.000
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1

Safety and Hazards(GHS)

Pictogram(s) GHS09,   GHS07
Signal Warning
Hazard Statements

H302:Harmful if swallowed

H312:Harmful in contact with skin

H332:Harmful if inhaled

H410:Very toxic to aquatic life with long lasting effects

Precautionary Statements

P261:Avoid breathing dust/fume/gas/mist/vapors/spray.

P273:Avoid release to the environment.

P280:Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352:IF ON SKIN: wash with plenty of water.

P321:Specific treatment (see ... on this label).

P501:Dispose of contents/container to ...

P264:Wash hands [and …] thoroughly after handling.

P271:Use only outdoors or in a well-ventilated area.

P270:Do not eat, drink or smoke when using this product.

P304+P340:IF INHALED: Remove person to fresh air and keep comfortable for breathing.

P362+P364:Take off contaminated clothing and wash it before reuse.

P391:Collect spillage.

P330:Rinse mouth.

P301+P317:IF SWALLOWED: Get medical help.

P317:Get emergency medical help.

Specifications

FAQs and Articles

References

1. Wu F, Büttner FH, Chen R, Hickey E, Jakes S, Kaplita P, Kashem MA, Kerr S, Kugler S, Paw Z et al..  (2010)  Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account..  Bioorg Med Chem Lett,  20  (11): (3235-9).  [PMID:20462760] [10.1021/op500134e]

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