Basic Description

Synonyms	ACES, BioPerformance Certified, >=99.0% \| Ethanesulfonic acid, 2-[(2-amino-2-oxoethyl)amino]- \| 3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine hydrochloride \| F20338 \| MFCD00008030 \| AKOS015892697 \| EINECS 230-908-4 \| Ethanesulfonic acid, 2-((2-ami
Specifications & Purity	≥99%
Biochemical and Physiological Mechanisms	Widely used zwitterionic buffer. Working pH range in aqueous solution: 6.1 - 7.5. Used as a buffereing component in cell culture media, agarose and polyacrylamide eletrophoresis and isoelectric focusing of proteins.
Shipped In	Normal
Product Description	ACES, or N-(2-Acetamido)-2-aminoethanesulfonic acid, can be used to study biological buffers and zwitterionic compounds. ACES has been used in a study to determine the levels of ibuprofen and flurbiprofen in pharmaceuticals by capillary zone electrophoresis.

Names and Identifiers

IUPAC Name	2-[(2-amino-2-oxoethyl)amino]ethanesulfonic acid
INCHI	InChI=1S/C4H10N2O4S/c5-4(7)3-6-1-2-11(8,9)10/h6H,1-3H2,(H2,5,7)(H,8,9,10)
InChi Key	DBXNUXBLKRLWFA-UHFFFAOYSA-N
Canonical SMILES	C(CS(=O)(=O)O)NCC(=O)N
Isomeric SMILES	C(CS(=O)(=O)O)NCC(=O)N
WGK Germany	3
Molecular Weight	182.2
Beilstein	2253770
Reaxy-Rn	2253770
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2253770&ln=

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

13 results found

Lot Number	Certificate Type	Date	Item
E2527260	Certificate of Analysis	May 09, 2025	A100327
E2527264	Certificate of Analysis	May 09, 2025	A100327
D2113022	Certificate of Analysis	Jan 08, 2025	A100327
D2113023	Certificate of Analysis	Jan 08, 2025	A100327
E2513100	Certificate of Analysis	Jul 09, 2024	A100327
E2513118	Certificate of Analysis	Jul 09, 2024	A100327
J2418705	Certificate of Analysis	Jul 01, 2024	A100327
E23181180	Certificate of Analysis	Feb 02, 2023	A100327
E23181181	Certificate of Analysis	Feb 02, 2023	A100327
E23181197	Certificate of Analysis	Feb 02, 2023	A100327
H2209068	Certificate of Analysis	Jul 22, 2022	A100327
H2209067	Certificate of Analysis	Jul 22, 2022	A100327
H2209065	Certificate of Analysis	Jul 22, 2022	A100327

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Chemical and Physical Properties

Solubility	Solvent:water, Max Conc. mg/mL: 18.22, Max Conc. mM: 100
Melt Point(°C)	＞220°C
Molecular Weight	182.200 g/mol
XLogP3	-4.700
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	5
Exact Mass	182.036 Da
Monoisotopic Mass	182.036 Da
Topological Polar Surface Area	118.000 Å²
Heavy Atom Count	11
Formal Charge	0
Complexity	217.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Safety and Hazards(GHS)

WGK Germany	3
Reaxy-Rn	2253770
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2253770&ln=

Specifications

Loss on drying	0-1（%）
Purity (Titration by NaOH)	99-101（%）
A290 UV Absorbance(c = 5%)	0-0.02
Heavy metal（as Pb）	0-5（ppm）
Appearance（A100327)	white crystalline powder
Infrared spectrum	Conforms to Structure
Solubility in H2O，Colorless Clear ,5 g plus 95 ml	pass

Specification Sheet

FAQs and Articles

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References

1. A Alonso. (1989-07-01) Human alpha-1-antitrypsin subtyping by hybrid isoelectric focusing in miniaturized polyacrylamide gel.. Electrophoresis, 10 ((7)): (513-519). [PMID:2789133]
2. D J Chappell. (1985-08-01) N-[(carbamoylmethyl)amino]ethanesulfonic acid improves phenotyping of alpha 1-antitrypsin by isoelectric focusing on agarose gel.. Clinical chemistry, 31 ((8)): (1384-1386). [PMID:3874722]
3. . (2003-11-19) COMET challenges paradigm of ACE inhibition in mild heart failure.. Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners, 14 ((4)): (207-208). [PMID:14619868]
4. Juan Peris-Vicente,Maria Rambla-Alegre,Abhilasha Durgavanshi,Devasish Bose,Josep Esteve-Romero,Sergio Marco-Peiró. (2013-11-14) Xanthine derivatives quantification in serum by capillary zone electrophoresis.. Journal of chromatographic science, 52 ((9)): (1121-1126). [PMID:24220991]
5. Marta Palusinska-Szysz,Agnieszka Szuster-Ciesielska,Magdalena Kania,Monika Janczarek,Elżbieta Chmiel,Witold Danikiewicz. (2014-05-14) Legionella dumoffii utilizes exogenous choline for phosphatidylcholine synthesis.. International journal of molecular sciences, 15 ((5)): (8256-8279). [PMID:24821544]
6. K Michelle Peavy,Joseph Guydish,Jennifer K Manuel,Barbara K Campbell,Nadra Lisha,Thao Le,Kevin Delucchi,Sharon Garrett. (2014-07-16) Treatment adherence and competency ratings among therapists, supervisors, study-related raters and external raters in a clinical trial of a 12-step facilitation for stimulant users.. Journal of substance abuse treatment, 47 ((3)): (222-228). [PMID:25017448]
7. Hasan Y Alniss,Marie-Virginie Salvia,Mykhailo Sadikov,Igor Golovchenko,Nahoum G Anthony,Abedawn I Khalaf,Simon P MacKay,Colin J Suckling,John A Parkinson. (2014-07-22) Recognition of the DNA minor groove by thiazotropsin analogues.. Chembiochem : a European journal of chemical biology, 15 ((13)): (1978-1990). [PMID:25045155]
8. Jaewoo Yoon,Kyoko Adachi,Hiroaki Kasai. (2014-11-12) Isolation and classification of a novel marine Bacteroidetes as Frondibacter aureus gen. nov., sp. nov.. Antonie van Leeuwenhoek, 107 ((2)): (321-328). [PMID:25385000]
9. Shadi Asadollahi,Kamran Heidari,Hamidreza Hatamabadi,Reza Vafaee,Somayeh Yunesian,Alireza Azadbakht,Ladan Mirmohseni. (2014-12-17) Efficacy and safety of valproic acid versus haloperidol in patients with acute agitation: results of a randomized, double-blind, parallel-group trial.. International clinical psychopharmacology, 30 ((3)): (142-150). [PMID:25500684]
10. Michael John Robert Previte,Chunhong Zhou,Matthew Kellinger,Rigo Pantoja,Cheng-Yao Chen,Jin Shi,BeiBei Wang,Amirali Kia,Sergey Etchin,John Vieceli,Ali Nikoomanzar,Erin Bomati,Christian Gloeckner,Mostafa Ronaghi,Molly Min He. (2015-01-24) DNA sequencing using polymerase substrate-binding kinetics.. Nature communications, 6 (5936-5936). [PMID:25612848]
11. Jaewoo Yoon,Hiroaki Kasai. (2015-06-20) Phylogenetic and taxonomic analysis of Neptunitalea chrysea gen. nov., sp. nov., a member of the phylum Bacteroidetes isolated from seawater by using an in situ cultivation technique.. Antonie van Leeuwenhoek, 108 ((3)): (537-544). [PMID:26089031]
12. J M Pope,P R Stevens,M T Angotti,R Nakon. (1980-04-01) Free metal ion depletion by "Good's" buffers. II. N-(2-acetamido)-2-aminoethanesulfonic acid (ACESH): complexes with calcium(II), magnesium(II), manganese(II), cobalt(II), zinc(II), nickel(II), and copper(II).. Analytical biochemistry, 103 ((2)): (214-221). [PMID:6247932]
13. P H Edelstein,M A Edelstein. (1993-12-01) Comparison of three buffers used in the formulation of buffered charcoal yeast extract medium.. Journal of clinical microbiology, 31 ((12)): (3329-3330). [PMID:8308131]
14. Yonghua Taylor Zhang,Jennifer Hu,Amanda L Pace,Rita Wong,Y John Wang,Yung-Hsiang Kao. (2014-07-08) Characterization of asparagine 330 deamidation in an Fc-fragment of IgG1 using cation exchange chromatography and peptide mapping.. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 965 (65-71). [PMID:24999246]

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SKU	Size	Availability	Price
A100327-25g	25g	3	$29.90
A100327-100g	100g	3	$79.90
A100327-500g	500g	3	$119.90

ACES - 99%, high purity , CAS No.7365-82-4