Determine the necessary mass, volume, or concentration for preparing a solution.
Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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SKU | Size | Availability | Price | Qty |
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A135946-250mg | 250mg | 2 | $9.90 | |
A135946-1g | 1g | Available within 4-8 weeks(?) Items will be manufactured post-order and can take 4-8 weeks. Thank you for your patience! | $19.90 | |
A135946-5g | 5g | 9 | $85.90 |
Potent, competitive, non-selective mAChR antagonist
Synonyms | (1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 3-hydroxy-2-phenylpropanoate | alpha-(Hydroxymethyl)benzeneacetic acid 8-methyl-8-azabicyclo(3.2.1)oct-3-yl ester | Atropine, >=95.0% (NT) | InChI=1/C11H8Cl2N2O/c12-8-1-2-9(10(13)5-8)11(16)6-15-4-3-14-7-15 |
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Specifications & Purity | Moligand™, ≥99% |
Biochemical and Physiological Mechanisms | Competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.Potent, competitive, non-selective mAChR antagonist (IC 50 = 2.5 nM). Induces mydriasis. Shows antimuscarinic and anticholinergic effects in vivo . Orally act |
Storage Temp | Store at 2-8°C,Protected from light,Argon charged |
Shipped In | Wet ice |
Grade | Moligand™ |
Action Type | ANTAGONIST |
Mechanism of action | Muscarinic acetylcholine receptor M2 antagonist |
Note | Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Toxic, refer to SDS for further information. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details. |
ALogP | 1.8 |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Pubchem Sid | 504757676 |
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Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504757676 |
IUPAC Name | [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate |
INCHI | InChI=1S/C17H23NO3/c1-18-13-7-8-14(18)10-15(9-13)21-17(20)16(11-19)12-5-3-2-4-6-12/h2-6,13-16,19H,7-11H2,1H3/t13-,14+,15?,16? |
InChi Key | RKUNBYITZUJHSG-PJPHBNEVSA-N |
Canonical SMILES | CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3 |
Isomeric SMILES | CN1[C@@H]2CC[C@H]1CC(C2)OC(=O)C(CO)C3=CC=CC=C3 |
WGK Germany | 3 |
RTECS | CK0700000 |
PubChem CID | 174174 |
Molecular Weight | 289.37 |
Beilstein | 91260 |
Find and download the COA for your product by matching the lot number on the packaging.
Lot Number | Certificate Type | Date | Item |
---|---|---|---|
Certificate of Analysis | Dec 12, 2023 | A135946 | |
Certificate of Analysis | Dec 12, 2023 | A135946 | |
Certificate of Analysis | Dec 12, 2023 | A135946 | |
Certificate of Analysis | Dec 12, 2023 | A135946 | |
Certificate of Analysis | Dec 12, 2023 | A135946 | |
Certificate of Analysis | Dec 12, 2023 | A135946 | |
Certificate of Analysis | Oct 21, 2023 | A135946 | |
Certificate of Analysis | Oct 21, 2023 | A135946 | |
Certificate of Analysis | Oct 21, 2023 | A135946 | |
Certificate of Analysis | Oct 21, 2023 | A135946 |
Solubility | Soluble in dilute aqueous acid, ethanol. |
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Sensitivity | Light & Air sensitive. |
Molecular Weight | 289.400 g/mol |
XLogP3 | 1.800 |
Hydrogen Bond Donor Count | 1 |
Hydrogen Bond Acceptor Count | 4 |
Rotatable Bond Count | 5 |
Exact Mass | 289.168 Da |
Monoisotopic Mass | 289.168 Da |
Topological Polar Surface Area | 49.800 Ų |
Heavy Atom Count | 21 |
Formal Charge | 0 |
Complexity | 353.000 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 2 |
Undefined Atom Stereocenter Count | 1 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
The total count of all stereochemical bonds | 0 |
Covalently-Bonded Unit Count | 1 |
Pictogram(s) | GHS06 |
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Signal | Danger |
Hazard Statements | H300+H330:Fatal if swallowed or if inhaled |
Precautionary Statements | P301+P310:IF SWALLOWED: Immediately call a POISON CENTER/doctor/... P310:Immediately call a POISON CENTER or doctor/physician. P264:Wash hands [and …] thoroughly after handling. P260:Do not breathe dust/fume/gas/mist/vapors/spray. P284:[In case of inadequate ventilation] Wear respiratory protection. |
WGK Germany | 3 |
RTECS | CK0700000 |
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1. Dianfa Zhao, Jie Liu, Yunshan Zhou, Lijuan Zhang, Yuxu Zhong, Yang Yang, Baoquan Zhao, Mengru Yang, Yong’an Wang. (2023) Penetrating the Blood–Brain Barrier for Targeted Treatment of Neurotoxicant Poisoning by Nanosustained-Released 2-PAM@VB1-MIL-101-NH2(Fe). ACS Applied Materials & Interfaces, 15 (10): (12631–12642). [PMID:36867458] [10.1021/acsami.2c18929] |
2. Dianfa Zhao, Jie Liu, Lijuan Zhang, Yunshan Zhou, Yuxu Zhong, Yang Yang, Chengcheng Huang, Yong’an Wang. (2022) Loading and Sustained Release of Pralidoxime Chloride from Swellable MIL-88B(Fe) and Its Therapeutic Performance on Mice Poisoned by Neurotoxic Agents. INORGANIC CHEMISTRY, 61 (3): (1512–1520). [PMID:34969248] [10.1021/acs.inorgchem.1c03227] |
3. Xue Zhao, Xiaoying Fu, Xinyi Yuan, Aerduosi Shayiranbieke, Ru Xu, Fang Cao, Jianping Ren, Qi Liang, Xinfeng Zhao. (2021) Development and characterization of a selective chromatographic approach to the rapid discovery of ligands binding to muscarinic-3 acetylcholine receptor. JOURNAL OF CHROMATOGRAPHY A, 1653 (462443). [PMID:34365202] [10.1016/j.chroma.2021.462443] |
4. Si Tang, Jing Zhu, Dong Zhao, Huaheng Mo, Zhaofu Zeng, Mengqing Xiong, Minglin Dong, Ke Hu. (2020) Effects of the excitation or inhibition of basal forebrain cholinergic neurons on cognitive ability in mice exposed to chronic intermittent hypoxia. BRAIN RESEARCH BULLETIN, 164 (235). [PMID:32905806] [10.1016/j.brainresbull.2020.08.027] |
5. Yushi Ding, Suyun Yu, Zhonghong Wei, Rui Deng, Peng Chen, Yifan Sun, Qi Jia, Xiaoman Li, Yuanyuan Wu, Wenxing Chen, Kurt S. Zanker, Aiyun Wang, Yin Lu. (2020) Relieving Sore Throat Formula Exerts a Therapeutic Effect on Pharyngitis through Immunoregulation and NF-κB Pathway. MEDIATORS OF INFLAMMATION, 2020 (2929163). [PMID:32508523] [10.1155/2020/2929163] |
6. Ke Chen, Yilei Zhao, Ting Liu, Zhaohao Su, Huiliang Yu, Leanne Lai Hang Chan, Tiejun Liu, Dezhong Yao. (2020) Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex. Jove-Journal of Visualized Experiments, (156): (e60600). [PMID:32090984] [10.3791/60600] |
7. Lianfang Chen, Junjie Ou, Hongwei Wang, Zhongshan Liu, Mingliang Ye, Hanfa Zou. (2016) Tailor-Made Stable Zr(IV)-Based Metal–Organic Frameworks for Laser Desorption/Ionization Mass Spectrometry Analysis of Small Molecules and Simultaneous Enrichment of Phosphopeptides. ACS Applied Materials & Interfaces, 8 (31): (20292–20300). [PMID:27427857] [10.1021/acsami.6b06225] |
8. Ji-Hong Chen, Qian Zhang, Yuanjie Yu, Kongling Li, Hong Liao, Longying Jiang, Lu Hong, Xiaohui Du, Xinghai Hu, Sifeng Chen, Sheng Yin, Qingmin Gao, Xiangdong Yin, Hesheng Luo, Jan D. Huizinga. (2013) Neurogenic and Myogenic Properties of Pan-Colonic Motor Patterns and Their Spatiotemporal Organization in Rats. PLoS One, 8 (4): (e60474). [PMID:23577116] [10.1371/journal.pone.0060474] |
1. Carr BJ, Mihara K, Ramachandran R, Saifeddine M, Nathanson NM, Stell WK, Hollenberg MD. (2018) Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro.. Invest Ophthalmol Vis Sci, 59 (7): (2778-2791). [PMID:29860464] [10.1021/op500134e] |
2. Radzicki D et al.. (2017) Loss of M1 Receptor Dependent Cholinergic Excitation Contributes to mPFC Deactivation in Neuropathic Pain.. J Neurosci, 37 (9): (2292-2304). [PMID:28137966] |
3. Huang H et al.. (2019) M1 Macrophage Activated by Notch Signal Pathway Contributed to Ventilator-Induced Lung Injury in Chronic Obstructive Pulmonary Disease Model.. J Surg Res, 244 (358-367). [PMID:31323391] |
4. Wang YJ et al.. (2017) The Analgesic Effects of (5R,6R)6-(3-Propylthio-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1] Octane on a Mouse Model of Neuropathic Pain.. Anesth Analg, 124 (4): (1330-1338). [PMID:28002166] |
5. Dianfa Zhao, Jie Liu, Yunshan Zhou, Lijuan Zhang, Yuxu Zhong, Yang Yang, Baoquan Zhao, Mengru Yang, Yong’an Wang. (2023) Penetrating the Blood–Brain Barrier for Targeted Treatment of Neurotoxicant Poisoning by Nanosustained-Released 2-PAM@VB1-MIL-101-NH2(Fe). ACS Applied Materials & Interfaces, 15 (10): (12631–12642). [PMID:36867458] [10.1021/acsami.2c18929] |
6. Dianfa Zhao, Jie Liu, Lijuan Zhang, Yunshan Zhou, Yuxu Zhong, Yang Yang, Chengcheng Huang, Yong’an Wang. (2022) Loading and Sustained Release of Pralidoxime Chloride from Swellable MIL-88B(Fe) and Its Therapeutic Performance on Mice Poisoned by Neurotoxic Agents. INORGANIC CHEMISTRY, 61 (3): (1512–1520). [PMID:34969248] [10.1021/acs.inorgchem.1c03227] |
7. Xue Zhao, Xiaoying Fu, Xinyi Yuan, Aerduosi Shayiranbieke, Ru Xu, Fang Cao, Jianping Ren, Qi Liang, Xinfeng Zhao. (2021) Development and characterization of a selective chromatographic approach to the rapid discovery of ligands binding to muscarinic-3 acetylcholine receptor. JOURNAL OF CHROMATOGRAPHY A, 1653 (462443). [PMID:34365202] [10.1016/j.chroma.2021.462443] |
8. Si Tang, Jing Zhu, Dong Zhao, Huaheng Mo, Zhaofu Zeng, Mengqing Xiong, Minglin Dong, Ke Hu. (2020) Effects of the excitation or inhibition of basal forebrain cholinergic neurons on cognitive ability in mice exposed to chronic intermittent hypoxia. BRAIN RESEARCH BULLETIN, 164 (235). [PMID:32905806] [10.1016/j.brainresbull.2020.08.027] |
9. Yushi Ding, Suyun Yu, Zhonghong Wei, Rui Deng, Peng Chen, Yifan Sun, Qi Jia, Xiaoman Li, Yuanyuan Wu, Wenxing Chen, Kurt S. Zanker, Aiyun Wang, Yin Lu. (2020) Relieving Sore Throat Formula Exerts a Therapeutic Effect on Pharyngitis through Immunoregulation and NF-κB Pathway. MEDIATORS OF INFLAMMATION, 2020 (2929163). [PMID:32508523] [10.1155/2020/2929163] |
10. Ke Chen, Yilei Zhao, Ting Liu, Zhaohao Su, Huiliang Yu, Leanne Lai Hang Chan, Tiejun Liu, Dezhong Yao. (2020) Monocular Visual Deprivation and Ocular Dominance Plasticity Measurement in the Mouse Primary Visual Cortex. Jove-Journal of Visualized Experiments, (156): (e60600). [PMID:32090984] [10.3791/60600] |
11. Lianfang Chen, Junjie Ou, Hongwei Wang, Zhongshan Liu, Mingliang Ye, Hanfa Zou. (2016) Tailor-Made Stable Zr(IV)-Based Metal–Organic Frameworks for Laser Desorption/Ionization Mass Spectrometry Analysis of Small Molecules and Simultaneous Enrichment of Phosphopeptides. ACS Applied Materials & Interfaces, 8 (31): (20292–20300). [PMID:27427857] [10.1021/acsami.6b06225] |
12. Ji-Hong Chen, Qian Zhang, Yuanjie Yu, Kongling Li, Hong Liao, Longying Jiang, Lu Hong, Xiaohui Du, Xinghai Hu, Sifeng Chen, Sheng Yin, Qingmin Gao, Xiangdong Yin, Hesheng Luo, Jan D. Huizinga. (2013) Neurogenic and Myogenic Properties of Pan-Colonic Motor Patterns and Their Spatiotemporal Organization in Rats. PLoS One, 8 (4): (e60474). [PMID:23577116] [10.1371/journal.pone.0060474] |