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SB 297006 - 98%, high purity , CAS No.58816-69-6

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SB 297006 - 98%, high purity , CAS No.58816-69-6

≥98%

CAS#: 58816-69-6
Molecular Weight: 342.35
MDL number: MFCD19690954
PubChem CID: 9840971
PubChem SID: 504764959

In stock

Item Number

S275456

Grouped product items
SKU	Size	Availability	Price
S275456-5mg	5mg	2	$78.90
S275456-10mg	10mg	6	$117.90
S275456-25mg	25mg	2	$246.90
S275456-50mg	50mg	6	$444.90
S275456-100mg	100mg	2	$741.90
S275456-250mg	250mg	2	$1,669.90
S275456-500mg	500mg	2	$3,005.90

Potent, selective CCR3 antagonist

View related series

C-protected amino acids (135) CCR (85) GPCR/G Protein (3169) Immunology/Inflammation (1927)

Basic Description

Synonyms	N-Benzoyl-4-nitroaniline ethyl ester \| Ethyl (2S)-2-benzamido-3-(4-nitrophenyl)propanoate \| AC-36264 \| SB 297006 \| AS-56057 \| B6053 \| BDBM50100041 \| MFCD19690954 \| HY-103361 \| (S)-Ethyl 2-benzamido-3-(4-nitrophenyl)propanoate \| EX-A2738 \| (S)-2-Benzoylami
Specifications & Purity	≥98%
Biochemical and Physiological Mechanisms	Highly potent, selective CCR3 antagonist (IC 50 = 2.5 μM). Displays 250-fold selectivity for CCR3 vs . CXCR1, CXCR2, CCR1 and CCR7 receptors. Potent inhibitor of Ca 2+ mobilization induced by eotaxin, eotaxin-2 and MCP-4 in human eosinophils (IC 50 values
Source	Synthetic
Storage Temp	Store at -20°C
Shipped In	Ice chest + Ice pads
Note	Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Product Description

Associated Targets(Human)

CCR3 Tchem C-C chemokine receptor type 3 (1 Activities)

Discover Target: CCR3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CCR3 Tchem C-C chemokine receptor type 3 (1666 Activities)

Discover Target: CCR3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HepG2 (196354 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

Hdac6 Histone deacetylase 6 (222 Activities)

Discover Target: Hdac6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

rep Replicase polyprotein 1ab (378 Activities)

Discover Target: rep

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Mechanism of Action	Action Type	target ID	Target Name	Target Type	Target Organism	Binding Site Name	References

Names and Identifiers

Pubchem Sid	504764959
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504764959
IUPAC Name	ethyl (2S)-2-benzamido-3-(4-nitrophenyl)propanoate
INCHI	InChI=1S/C18H18N2O5/c1-2-25-18(22)16(19-17(21)14-6-4-3-5-7-14)12-13-8-10-15(11-9-13)20(23)24/h3-11,16H,2,12H2,1H3,(H,19,21)/t16-/m0/s1
InChi Key	BEZXGSZPWXRHIN-INIZCTEOSA-N
Canonical SMILES	CCOC(=O)C(CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC=CC=C2
Isomeric SMILES	CCOC(=O)[C@H](CC1=CC=C(C=C1)[N+](=O)[O-])NC(=O)C2=CC=CC=C2
PubChem CID	9840971
Molecular Weight	342.35

Certificates（CoA,COO,BSE/TSE and Analysis Chart)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

7 results found

Lot Number	Certificate Type	Date	Item
A2312347	Certificate of Analysis	Oct 18, 2023	S275456
A2312328	Certificate of Analysis	Oct 18, 2023	S275456
A2312263	Certificate of Analysis	Oct 18, 2023	S275456
A2312368	Certificate of Analysis	Oct 18, 2023	S275456
A2312384	Certificate of Analysis	Oct 18, 2023	S275456
A2312379	Certificate of Analysis	Oct 18, 2023	S275456
A2312350	Certificate of Analysis	Oct 18, 2023	S275456

Chemical and Physical Properties

Solubility	Soluble in DMSO to 100 mM and in ethanol to 25 mM
Sensitivity	Heat Sensitive
Specific Rotation[α]	-86° (C=1,EtOH)
Melt Point(°C)	121 °C
Molecular Weight	342.300 g/mol
XLogP3	3.300
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	7
Exact Mass	342.122 Da
Monoisotopic Mass	342.122 Da
Topological Polar Surface Area	101.000 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	463.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Safety and Hazards(GHS)

Pictogram(s)	GHS09, GHS07
Signal	Warning
Hazard Statements	H302:Harmful if swallowed H400:Very toxic to aquatic life
Precautionary Statements	P273:Avoid release to the environment. P501:Dispose of contents/container to ... P264:Wash hands [and …] thoroughly after handling. P270:Do not eat, drink or smoke when using this product. P391:Collect spillage. P330:Rinse mouth. P301+P317:IF SWALLOWED: Get medical help.

Specifications

Specification Sheet

Alternative Products

References

1. Kuse Y et al.. (2017) CCR3 Is Associated with the Death of a Photoreceptor Cell-line Induced by Light Exposure.. Front Pharmacol, 8 (207). [PMID:28458639]

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